AZD7442 showed no benefit over placebo and increased rehospitalization risk in hospitalized COVID-19 adults
A COVID Antibody Drug That Looked Promising Didn't Deliver
This Phase 3 randomized multicentre trial evaluated tixagevimab-cilgavimab (AZD7442) versus placebo in 237 hospitalized adults with PCR-conf…
A rigorous 15-month trial found that a promising COVID antibody drug offered no clinical benefit to hospitalized patients and led to more re…
Meta-analysis finds 30.5% breakthrough UTI rate in children with VUR on antibiotic prophylaxis
A Scorecard to Spot Kids at Highest Risk of Kidney Infections
A meta-analysis of 24 cohort studies (n=3,264) in children with vesicoureteral reflux on continuous antibiotic prophylaxis found a pooled br…
A new eight-clue scorecard helps doctors spot which children on daily antibiotics are most likely to still get a kidney infection.
High-volume interval exercise linked to higher enjoyment in people with HIV versus healthy controls
High-intensity interval exercise boosted enjoyment in people living with HIV compared to healthy controls
A single-blind crossover study of 11 people living with HIV and 11 healthy controls found that high-volume high-intensity interval exercise …
People living with HIV reported higher enjoyment during high-volume intense workouts compared to healthy controls in a new study.
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Alpha-glucosidase inhibitors like acarbose show anti-virulence activity against Candida albicans in vitro
Could common diabetes drugs help stop fungal infections from building tough protective shields?
This systematic review evaluated alpha-glucosidase inhibitors, particularly acarbose, as selective antifungal inhibitors against Candida alb…
A common diabetes drug called acarbose may help break down the tough shields that hide dangerous fungal infections from treatment.
Systematic review examines pulmonary co-infection with M. septicum and M. nivoides
When One Lung Infection Is Really Two Sneaky Cousins
A systematic review of a pulmonary co-infection case and 19 additional M.
Two nearly identical bacteria hiding in one lung infection may be evolving to become more aggressive while current lab tests miss them.
Systematic review of Mycobacterium riyadhense infection in 69 cases shows common presentations and drug susceptibility patterns
A rare infection hits lungs and bones: what doctors need to know about treating Mycobacterium riyadhense
A systematic review and meta-analysis of 69 immunocompetent and immunocompromised patients with Mycobacterium riyadhense infection found pne…
A rare lung and bone infection called Mycobacterium riyadhense often resists standard drugs, leaving doctors without agreed-upon treatment p…
Vaccines show protective effects against rotavirus and pneumococcal disease in sub-Saharan African children
Vaccine Results Might Be Wrong Without These Factors
This systematic review and meta-analysis of 64 studies assessed vaccine effectiveness in children under five years in sub-Saharan Africa.
Vaccine studies in Africa often miss other health changes happening at the same time, which can make shots look more effective than they rea…
Relaxation of COVID-19 NPIs in Nanjing children showed high pathogen detection rates with preschoolers having the highest burden
When COVID rules lifted, did kids get sicker or just catch more common bugs?
This retrospective cohort study examined 7,473 children (≤18 years) presenting with acute respiratory tract infections in a tertiary hospita…
After COVID rules lifted, common cold viruses and bacteria caused most children's breathing issues, with young kids facing the highest risk …
Streptococcus agalactiae is a predominant cause of prosthetic joint infections in adults with specific risk factors
Hidden Bacteria: Why Your Diabetes Risks Bone Infections
This retrospective cohort study analyzed 1,454 adults in a West Region registry to identify risk factors for Streptococcus agalactiae bone a…
A hidden bacteria called S. agalactiae is the top cause of slow-healing bone infections in people with diabetes, obesity, or poor blood flow…
mNGS testing shows higher pathogen detection than culture in complex skin infections
A DNA-Reading Test Is Finding Infections That Standard Lab Cultures Miss
A retrospective cohort study of 69 patients with complex SSTIs found mNGS testing demonstrated significantly higher pathogen detection rates…
A new DNA test found infections in 83% of skin cases where standard lab cultures came back negative, helping doctors target the right bacter…
Peg-IFN-alpha treatment in HBeAg-negative chronic hepatitis B yields virological and serological responses
New Blood Test Predicts Hep B Drug Success
This prospective cohort study evaluated HBeAg-negative chronic hepatitis B patients treated with pegylated interferon alpha over 48 weeks.
A new blood test checks specific genes to predict if hepatitis B patients will respond to treatment before wasting months on ineffective med…