Meta-analysis finds endothelial swelling and plasma cell infiltration common in secondary syphilis histology
What do syphilis skin lesions look like under the microscope? A new review finds patterns.
A systematic review and meta-analysis of eight studies involving 384 patients with secondary syphilis found endothelial swelling (85% preval…
When blood tests or rashes aren't clear, doctors use skin biopsies to spot swelling in tiny blood vessels and dense white blood cell cluster…
Small pilot study finds gut microbiome differences in diarrheal versus non-diarrheal samples
Small study finds gut bacteria differences in people with and without diarrhea
A cross-sectional observational pilot study of 28 fecal samples (23 non-diarrheal, 5 diarrheal) found significant differences in gut microbi…
Gut bacteria structures differ significantly between people with and without diarrhea, with Firmicutes being the most common type found in m…
MT-2301 Hib vaccine candidate shows efficacy in phase 2 study of 154 infants
How well does a new Hib vaccine protect infants when given with other routine shots?
A phase 2 study evaluated the efficacy and safety of MT-2301 (Haemophilus b conjugate vaccine) co-administered with DPT-IPV in healthy infan…
A new Hib vaccine given with routine shots reached the same antibody protection levels as the current approved vaccine in healthy infants.
Phase 1/2/3 trial of BNT162b2, BNT162b1, and BNT162b2SA COVID-19 vaccines in 46,969 healthy individuals
How did the original COVID-19 vaccine hold up? A massive study tested its safety and effectiveness in nearly 47,000 people.
This Phase 1/2/3, randomized, placebo-controlled, observer-blind study evaluated the safety, tolerability, immunogenicity, and efficacy of t…
A massive study tested the safety and effectiveness of the original COVID-19 vaccine in nearly 47,000 healthy people across different ages.
Bictegravir-lenacapavir single-tablet regimen non-inferior to complex regimens for HIV-1 suppression at 48 weeks
Can a single daily pill control HIV as well as complex multi-pill regimens?
In this phase 3 randomized trial of 557 virologically suppressed adults with HIV-1 on complex regimens, switching to once-daily oral bictegr…
A new single daily pill kept HIV suppressed just as well as complex multi-pill regimens in a trial of 557 adults who had been on treatment f…
Potential drug interactions did not affect rifampin TB prevention completion or adverse events
Do drug interactions make tuberculosis prevention harder to finish?
A secondary analysis of 1368 participants in a rifampin TPT trial found no difference in treatment completion or adverse events between thos…
Tuberculosis prevention treatment works safely with other drugs, but patients taking them face more unscheduled doctor visits during the cou…
Livelihood Intervention Reduces Food Insecurity and Depression in HIV-Affected Kenyan Adolescents
Can improving livelihoods help HIV-affected teens feel better and safer?
A Kenyan RCT found that an agricultural livelihood intervention reduced food insecurity (OR: 0.45; p=0.04) and depressive symptoms (OR: 0.53…
An agricultural program in Kenya helped HIV-affected teens feel safer by reducing food insecurity, depression, anxiety, and intimate partner…
Phase 2 Trial Evaluates mRNA Influenza Vaccines' Safety and Immunogenicity in Adults
Could This New Vaccine Help Us Finally Beat the Flu?
This Phase 2 trial investigates the safety and immunogenicity of five mRNA-based influenza vaccines in 770 healthy adults. Primary outcomes …
Pfizer is testing new mRNA flu vaccines in healthy adults to see if they trigger a stronger immune response and reduce flu complications bet…
Dasatinib and Quercetin Show Promise in Improving Gait Speed in HIV-Associated Frailty
Can a New Drug Combination Help Older Adults with HIV Regain Strength?
Phase II trial of dasatinib and quercetin (D+Q) in 82 HIV+ frail/prefrail adults shows potential in improving gait speed. Primary endpoint: …
A new trial tests if two drugs help older adults with HIV regain strength and walk better after years of frailty.
Antibiotics for Appendicitis: 37.8% Recurrence, 44.3% Appendectomy at 10 Years
Is Antibiotic Treatment for Appendicitis a Safe Long-Term Option?
In a 10-year follow-up of the APPAC trial, 37.8% of patients treated with antibiotics for uncomplicated appendicitis experienced recurrence,…
Nearly half of patients treated with antibiotics for appendicitis avoided surgery entirely over 10 years, though about 38% experienced a rec…
Rapid Diagnostics Align 65% of ICU Antibiotic Prescriptions with Pathogen Results
Why Are Doctors Hesitant to Trust Quick Test Results for Pneumonia?
In the INHALE RCT, 65% of ICU antibiotic prescriptions aligned with BioFire FilmArray Pneumonia Panel results. Positive pathogen results led…
When rapid pneumonia tests find no germs, doctors often ignore the result and keep prescribing antibiotics, risking longer hospital stays an…