Acoustic stimulation provides adjunctive analgesic value for managing acute and chronic pain conditions
Acoustic Stimulation Shows Potential for Managing Chronic and Acute Pain
This narrative review explores the efficacy of acoustic stimulation modalities including music therapy, natural sounds, and vibroacoustic th…
Different types of sound therapy, including music and natural sounds, may help manage both sudden and long-term pain as a non-drug treatment…
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
Ferroptosis Linked to Spinal Cord Injury and Disc Degeneration
This mini review proposes a ferroptosis-mediated domino effect connecting intervertebral disc degeneration, spinal deformity, and spinal cor…
A new theoretical framework suggests that a specific type of cell death may link disc degeneration to spinal cord injury.
FDA Approves Rextovy (naloxone) Nasal Spray for Opioid Overdose Emergency Treatment
FDA approves Rextovy nasal spray for emergency opioid overdose treatment.
FDA approved Rextovy (naloxone) 4 mg nasal spray for emergency treatment of known or suspected opioid overdose in adults and pediatric patie…
The FDA approved Rextovy (naloxone hydrochloride) nasal spray for emergency treatment of opioid overdose in adults and children. It is meant…
Transcatheter aortic valve replacement shows comparable mortality to surgery in severe symptomatic aortic stenosis
Trial compares TAVR and surgery for aortic stenosis
This trial compared transcatheter aortic valve replacement with surgical aortic valve replacement in patients with severe symptomatic aortic…
A large trial shows that while TAVR and surgery have similar survival rates, TAVR may lead to more frequent follow-up procedures over time.
Fecal microbiota transplantation improves motor function and constipation in patients with Parkinson disease
Fecal transplants improve Parkinson's motor symptoms in short term
This meta-analysis of 220 adults with mild to moderate Parkinson disease found that fecal microbiota transplantation (FMT) significantly imp…
A meta-analysis finds fecal transplants may temporarily improve motor and constipation symptoms in Parkinson's, but effects fade.
One Health approach in Chagas disease remains fragmented, review finds
One Health Approach Shows Gaps in Chagas Disease Research
A systematic review of 68 documents found that the One Health approach in Chagas disease studies predominantly focuses on animal health (41.…
A review of research shows that most studies on Chagas disease focus only on animal health rather than integrating human and environmental f…
Tenecteplase shows no significant difference in serious adverse event distribution compared to alteplase
Trial shows tenecteplase is as safe as alteplase for stroke
This multicenter Phase 3 randomized controlled trial post-hoc analysis involved 1577 ischemic stroke patients presenting within 4.5 hours of…
A large study of over 1,500 patients confirms that the clot-busting drug tenecteplase has a similar safety profile to the standard treatment…
Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
Safinamide beats rasagiline for Parkinson's motor symptoms
This network meta-analysis of randomized controlled trials evaluated various adjunct therapies for Asian Parkinson's disease patients with m…
For Asian Parkinson's patients, adding safinamide to levodopa reduces OFF-time more than rasagiline or zonisamide.
PINGS intervention improves systolic blood pressure control to 67% compared to 43% in usual care
Nurse Case Management Improves Blood Pressure for Stroke Survivors
This Phase 3 randomized controlled trial involved 500 adults with stroke and elevated blood pressure. The PINGS intervention, involving nurs…
A new mobile health program using nurse support and phone reminders helped more stroke survivors reach lower blood pressure targets.
Anterior location and complex trauma are associated with higher mortality in superior sagittal sinus injuries
Penetrating Brain Sinus Injuries: 27% Mortality in 51 Cases
This systematic review of 51 cases characterizes penetrating injuries of the superior sagittal sinus across various mechanisms. The analysis…
A review of 51 cases finds 27% mortality in penetrating injuries to a major brain sinus, with nails and bullets common causes.
Vasospasm after thrombectomy may signal microvascular failure needing vasodilators
New Perspectives on Managing Blood Flow After Ischemic Stroke
This mini-review proposes that vasospasm after mechanical thrombectomy for large-vessel occlusion ischemic stroke indicates a complex reperf…
New research suggests that identifying specific blood vessel issues after a stroke could help doctors better target treatments to improve ti…
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
Minimally Invasive Surgery Shows Better Outcomes for Brain Bleeds
This network meta-analysis of 18 randomized controlled trials evaluated surgical interventions for spontaneous intracerebral hemorrhage. MIP…
New research suggests minimally invasive and endoscopic surgeries may offer better functional recovery for patients with brain bleeds compar…