High-dose corticosteroids combined with IVIG or plasma exchange are preferred for triple-M syndrome
Triple-M Syndrome Linked to Immune Checkpoint Inhibitor Therapy
This systematic review of case reports and series examines the management of triple-M syndrome following immune checkpoint inhibitor therapy…
Patients receiving immune checkpoint inhibitors may develop triple-M syndrome, a serious combination of muscle, heart, and nerve issues requ…
Bevacizumab plus lomustine significantly improves progression-free survival in recurrent or refractory glioblastoma
Bevacizumab Plus Lomustine Shows Potential for Glioblastoma Patients
This systematic review and network meta-analysis of randomized trials evaluated various treatments for recurrent or refractory glioblastoma.…
A combination of bevacizumab and lomustine showed a significant improvement in progression-free survival for adults with recurrent glioblast…
Rasagiline and selegiline show comparable efficacy and safety in early Parkinson's disease
Rasagiline and selegiline offer similar relief for early Parkinson's
This meta-analysis indirectly compared rasagiline with selegiline in early Parkinson's disease, finding no statistically significant differe…
Two common medications for early Parkinson's disease provide similar symptom relief, but one option may be more expensive than the other.
Idarucizumab-mediated reversal of dabigatran before thrombolysis shows 66.6% good functional outcome at 90 days
New data shows outcomes for stroke patients on dabigatran medication
This systematic review and single-arm meta-analysis of 226 patients evaluated intravenous thrombolysis following idarucizumab-mediated rever…
A new review looks at how patients who have a stroke while taking dabigatran respond to specific reversal treatments.
Ginseng components show potential neuroprotective effects in preclinical models of multiple neurodegenerative diseases
Ginsenosides Show Potential Neuroprotective Effects for Several Brain Diseases
This systematic review synthesizes evidence regarding the role of ginseng and its active components, such as ginsenosides, in models of Alzh…
Research into ginseng components suggests potential neuroprotective benefits for conditions like Alzheimer's and Parkinson's, though results…
FDA Approves Zavzpret (zavegepant) for Acute Treatment of Migraine in Adults
FDA approves new nasal spray Zavzpret for quick migraine relief in adults.
The FDA has approved Zavzpret (zavegepant) nasal spray for the acute treatment of migraine with or without aura in adults. Approval was base…
The FDA has approved Zavzpret (zavegepant) nasal spray for the acute treatment of migraine in adults. It offers a non-oral option that works…
Transcranial Doppler monitoring aims to reduce new DWI lesions by 50% in carotid stenting
New Trial Plans to Use TCD Monitoring for Carotid Stenosis
This randomized controlled trial protocol describes a study of 232 patients scheduled for carotid artery stenting with severe internal carot…
A new clinical trial aims to see if transcranial Doppler monitoring can reduce brain lesions during carotid artery stenting procedures.
Combined transcranial electrical stimulation with physical or behavioral interventions reduces chronic nonspecific low back pain
Brain stimulation shows promise when combined with other treatments
This systematic review and meta-analysis of 19 randomized controlled trials evaluated transcranial electrical stimulation for chronic nonspe…
New data suggests that brain stimulation can help reduce chronic low back pain, but only when paired with physical or behavioral therapies.
Non-invasive brain stimulation fails to show consistent cognitive benefit after traumatic brain injury
Brain stimulation for TBI: no clear cognitive benefit found
This umbrella review of meta-analyses found inconsistent evidence for cognitive benefit from non-invasive brain stimulation (NIBS) in trauma…
A new review finds inconsistent evidence that brain stimulation helps thinking after traumatic brain injury. What does this mean for patient…
Glymphatic system failure following acute brain injury drives systemic inflammation and pulmonary damage
Brain injury may cause lung damage through a shared pathway
This narrative review explores the brain-lung axis, where glymphatic dysfunction after acute brain injury leads to neurogenic toxin spillove…
A damaged brain can release toxins that travel through the body and harm the lungs, creating a dangerous link between these two organs.
Microbial phenolic metabolites may cross the blood-brain barrier and reduce neuroinflammation
Microbial metabolites may help protect the brain from aging
This mini-review synthesizes evidence that low-molecular-weight microbial phenolic metabolites can cross blood-brain barrier models, modify …
Small molecules produced by gut microbes could cross into the brain to strengthen blood vessels and reduce inflammation linked to aging.
Mechanical thrombectomy shows potential for favorable outcomes in pediatric large-vessel occlusion stroke
Mechanical Thrombectomy May Help Children After Stroke
This meta-analysis of observational studies evaluates mechanical thrombectomy (MT) compared to medical management and specific treatments fo…
A new analysis suggests mechanical thrombectomy may improve outcomes in children with large-vessel occlusion stroke, but more research is ne…