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Elevated plasma CD147 levels are associated with 1.75 odds ratio for poststroke cognitive impairmentHigher CD147 levels linked to cognitive issues after stroke

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Key Takeaway
Note that elevated plasma CD147 levels are associated with higher odds of poststroke cognitive impairment.

This observational study, conducted as a preplanned ancillary study of a clinical trial, included 612 patients with ischemic stroke. The primary objective was to evaluate the relationship between plasma CD147 levels and poststroke cognitive impairment (PSCI) over a 3 month follow-up period.

Analysis of the primary outcome revealed that 317 out of 612 participants developed PSCI, as defined by the Mini-Mental State Examination. Elevated plasma CD147 levels were associated with higher odds of PSCI (odds ratio, 1.75; 95% CI, 1.21-2.51). Additionally, a linear association between plasma CD147 and PSCI was observed (linearity=0.038).

Secondary outcomes assessed the discriminatory power of CD147 when combined with conventional risk factors. The C statistic improved from 0.695 to 0.711 (0.016 increase; p=0.047) when CD147 was included. No safety or tolerability data were reported.

Because this was an observational study, the results indicate an association only and do not establish a causal role for CD147 in the pathophysiology of poststroke cognitive impairment. The clinical utility of CD147 as a biomarker remains to be established in larger, prospective cohorts.

When someone suffers a stroke, the immediate danger is often physical. However, many patients face a hidden challenge: lasting cognitive impairment. This is the lasting mental fog or memory issues that can make daily life difficult after a stroke. Researchers are looking for ways to identify who might be at risk for these lasting issues early on.

In a study of 612 patients who had an ischemic stroke, researchers looked at a protein in the blood called CD147. They found that patients with higher levels of this protein had significantly higher odds of developing cognitive impairment. Specifically, those with elevated CD147 levels were more likely to show signs of mental decline during a follow-up three months after their stroke.

While this study shows a clear link between the protein and brain health, it is important to remember that this is an observational study. This means the researchers found a connection, but they cannot say for certain that the protein causes the cognitive issues. It is a helpful piece of the puzzle in understanding how to better predict and manage recovery after a stroke.

What this means for you:
Higher levels of the CD147 protein in the blood are linked to a higher risk of cognitive issues after a stroke.

Common questions

What is the link between CD147 and stroke recovery?

The study found that patients with higher levels of the CD147 protein in their blood had higher odds of experiencing cognitive impairment after a stroke. This means the protein could be a useful marker to help identify which patients might struggle with mental clarity or memory issues during their recovery.

How many people were involved in this study?

The study included 612 patients who had an ischemic stroke. Out of those 612 people, 317 participants were found to have developed post-stroke cognitive impairment, which was measured using a standard mental state test.

Does a high CD147 level mean a person will definitely have memory problems?

Not necessarily. This was an observational study, which means it shows a link between the protein and cognitive issues, but it does not prove that the protein causes the problem. Because it is an association, you should talk to a doctor to understand what these results mean for a specific patient.

Study Details

Study typeRct
Sample sizen = 612
EvidenceLevel 2
Follow-up3.0 mo
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: Cluster of differentiation 147 (CD147) is a multifunctional transmembrane glycoprotein, but its effect on poststroke cognitive impairment (PSCI) is unclear. METHODS: The current study included 612 patients with ischemic stroke with plasma CD147 levels from a preplanned ancillary study of CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). Mini-Mental State Examination and Montreal Cognitive Assessment were used to evaluate cognitive function at the 3-month follow-up visit. PSCI was defined as a score of <27 for Mini-Mental State Examination or <25 for Montreal Cognitive Assessment. Logistic regression models and restricted cubic spline analyses were used to assess the associations between CD147 and PSCI. RESULTS: As defined by Mini-Mental State Examination, 317 participants developed PSCI. After multivariate adjustment, elevated plasma CD147 levels were significantly associated with higher odds of PSCI (odds ratio, 1.75 [95% CI, 1.21-2.51]). Multiple-adjusted spline regression model showed a linear association between plasma CD147 level and PSCI ( for linearity=0.038). Furthermore, adding plasma CD147 to conventional risk factors improved the discriminatory power (C statistics, 0.695 versus 0.711; =0.047). Similar findings were observed when PSCI was defined by the Montreal Cognitive Assessment. CONCLUSIONS: Elevated plasma CD147 levels at admission were associated with higher odds of cognitive impairment at 3 months after stroke among patients with acute ischemic stroke, suggesting its potential role in the pathophysiological processes of PSCI. REGISTRATION: URL: https://clinicaltrials.gov/study/NCT01840072; Unique Identifier: NCT01840072.
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