Sex-specific exposome components influence vulnerability to Major Depressive Disorder in women.
Why Women Get Sicker From Stress
This mini-narrative review examines sex-specific exposome components, including environmental and social exposures, neuroendocrine signaling…
Women face nearly double the lifetime risk of depression because environmental toxins and early-life stress permanently alter brain chemistr…
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease.
An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Narrative review of continuously administered IV anesthetics for status epilepticus management in adults.
Review finds no clear best way to manage severe seizures with IV anesthetics
This narrative scoping review evaluated continuously administered intravenous anesthetic drugs (CIVAD) for status epilepticus in non-anoxic …
There is no single best way to manage severe seizures with IV anesthetics, as current evidence shows conflicting results on timing and uncle…
PETRA-MRA shows improved image quality and occlusion rates in intracranial aneurysm follow-up
New Scan Clears Metal Scars to See Brain Arteries
A prospective comparative study of 100 patients with intracranial aneurysms found PETRA-MRA image quality improved from postoperative day 1 …
This new imaging trick lets doctors see inside your brain without needles or dyes, making check-ups safer and easier.
Retrospective cohort describes Parsonage-Turner syndrome presentation and recovery in 42 patients
The Shoulder Pain Many Doctors Miss for Weeks
A retrospective cohort of 42 patients with Parsonage-Turner syndrome at a Chinese hand surgery center found an average annual incidence of 4…
A rare nerve disorder often starts with severe shoulder pain, yet diagnosis takes two months on average, delaying treatment and recovery.
JUST Score variables predict hemorrhagic versus ischemic stroke differentiation in EMS-transported patients.
Can Paramedics Tell Which Stroke You're Having?
This cohort review evaluated North American adult patients with ischemic or hemorrhagic stroke transported by emergency medical services. Th…
A simple checklist used by paramedics can hint at which kind of stroke you're having, so they can rush you to a hospital that actually treat…
First-line platinum-based chemotherapy associated with disease control and survival in recurrent NSCLC patients.
Chemotherapy Changes Your Immune Cells
This cohort study evaluated 42 patients with recurrent unresectable locally advanced or stage IV NSCLC without actionable mutations receivin…
Standard lung cancer chemotherapy can reshape the body's immune defenses instead of just destroying them, helping patients control their dis…
Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinence
Does stress incontinence and constipation change how your brain works?
A cohort study of 34 female patients with functional constipation and stress urinary incontinence (FCon-SUI), 24 with functional constipatio…
Women with both constipation and incontinence show unique brain activity patterns linked to movement control and visual processing that diff…
Prospective cohort study links age, GCS, and CT scores to posttraumatic confusional state duration in TBI patients.
How Long Is the Confusion After a Brain Injury
A prospective inception cohort of 424 neurosurgical patients with moderate or severe traumatic brain injury found that shorter PTCS duration…
Age and injury severity, not past education or brain health, determine how long confusion lasts after a serious head injury.
Genetic mutations in febrile sensitivity epilepsy correlate with earlier onset and specific diagnoses in children.
Fever-Triggered Seizures in Children Trace Back to Specific Genes
This retrospective cohort study examined 30 gene-positive cases and 31 gene-negative controls at Wuxi Children's Hospital. Results indicated…
Half of children with fever-triggered seizures carry specific gene mutations that help doctors predict which treatments will work and which …
Targeted nanopore sequencing and biomarkers show diagnostic and prognostic value in intracranial infections
A DNA-Sequencing Tool Is Changing How Brain Infections Get Diagnosed
A retrospective cohort study of 255 patients with suspected intracranial infections found that targeted nanopore sequencing identified commo…
A fast genetic test paired with routine blood markers helps doctors quickly identify the cause of brain infections, potentially reducing tim…
Vascular risk factors and diagnostic findings in young stroke patients across sixteen MENA centers
Young Adults Are Having Strokes — And the Causes May Surprise You
This retrospective cohort study examined 3,971 young adults with stroke across nine Middle East and North Africa countries. Hypertension was…
High blood pressure and diabetes are driving strokes in young adults across the Middle East and North Africa, creating distinct risks that d…