Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
Can a simple blood test tell Alzheimer's from frontotemporal dementia?
An observational cohort study of 101 Asian individuals with known pTau217 status used plasma proteomics profiling to identify 1,168 proteins…
A simple blood test could distinguish Alzheimer's from frontotemporal dementia by spotting unique protein patterns linked to brain inflammat…
Observational cohort finds high cardiac involvement and variable treatment patterns in hATTR patients
Heart Treatment Often Misses Nerve Damage in This Group
This single-center retrospective cohort study of 54 patients with hereditary transthyretin amyloidosis (hATTR) found 94.4% had cardiac invol…
Heart patients with a common African American gene variant often get nerve damage missed, leaving tingling hands untreated while doctors foc…
Etalanetug reduces CSF tau biomarkers in dominantly inherited Alzheimer's disease in phase 1b/2 study
Can a new drug slow Alzheimer's toxic tau protein in the brain?
This open-label phase 1b/2 study in 8 participants with mild-to-moderate cognitive impairment due to dominantly inherited Alzheimer's diseas…
An early study shows an experimental drug lowers two key tau proteins in spinal fluid for people with a rare inherited form of Alzheimer's.
Protocol for observational study of digital cognitive assessments in post-COVID-19 condition
New Tool Spots “Brain Fog” After COVID in Just 15 Minutes
This is a protocol for a single-center, cross-sectional observational study in the Luxembourgish Predi-COVID cohort.
A new digital tool spots lingering brain fog after COVID in just 15 minutes, offering a faster alternative to long clinic visits for million…
Observational analysis of a multi-channel blood biomarker framework for Alzheimer's amyloid detection
Can a simple blood test spot Alzheimer's brain changes as well as a brain scan?
This observational analysis from the ADNI cohort evaluates a Virtual Spectral Decomposition (VSD) framework using plasma biomarkers to detec…
A new blood test combining four markers spots Alzheimer's brain changes with 90% accuracy, outperforming single-marker tests without needing…
Non-randomized trial of Zoom system for LVO stroke reperfusion exceeds performance goals
Can a new stroke device clear deadly clots faster and more often?
This is a prospective, multicenter, non-randomized investigational device exemption trial in 260 adults with anterior circulation LVO stroke…
A new stroke device cleared deadly clots in 83% of patients within three tries, restoring blood flow in just 19 minutes.
Non-randomized trial of neuromodulation prehabilitation for brain tumor language networks
Small study tests brain stimulation and language training before brain tumor surgery
This is a non-randomized controlled trial in 26 patients with operable brain tumors.
Brain stimulation and language training before surgery reduced overlap between stimulation targets and language areas in patients with opera…
Diagnostic accuracy study of EEG network measures for epilepsy versus functional seizures
EEG Network Measures May Help Distinguish Epilepsy From Functional Seizures
This diagnostic accuracy study evaluated multivariate resting-state EEG network measures in 148 individuals with suspected seizure disorders…
EEG network measures can distinguish epilepsy from functional seizures with 67.5% accuracy, offering a new tool to help doctors diagnose sei…
Observational study validates EOG-to-VOG transformation model for horizontal saccades in healthy adults
New Eye Test Matches Gold Standard for Accuracy
This prospective observational study in 4 healthy adults developed and validated a mathematical model to convert electrooculography (EOG) da…
A simple, pocket-sized eye test now matches expensive gold-standard gear for checking brain health, though it is not yet ready for clinics.
Re-analysis of MRI data shows multivariate approach detects more age-related brain changes but has cross-validation limitations
New MRI Scans Reveal How Your Brain Changes With Age—And What It Means
This is a re-analysis of observational MRI data comparing multivariate and univariate methods.
New MRI scans can spot early brain aging by measuring water, iron, and myelin changes in specific areas like the hippocampus and cerebellum.
Genetic analyses suggest causal links between type 2 diabetes markers and cerebral small vessel disease phenotypes
High Blood Sugar May Drive Small Stroke Risk
This review synthesizes genome-wide association and Mendelian randomization data linking type 2 diabetes and glycemic indicators to cerebral…
Managing blood sugar after meals might lower your risk of a specific type of stroke.
Prospective open-label study links brain MRI to impulse control changes after DBS for Parkinson's
Can brain scans predict impulse problems after Parkinson's surgery?
This prospective open-label study of 35 patients with advanced Parkinson's disease undergoing subthalamic deep brain stimulation found that …
Healthy brain wiring in key areas may help predict who develops impulse control problems after Parkinson's deep brain stimulation surgery.