Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Cross-sectional review links illness perceptions to quality of life variance in Parkinson disease patients
Parkinson’s patients’ mindset affects quality of life more than symptoms
This cross-sectional study reviews data from 58 people with idiopathic Parkinson disease across multiple centers.
Many Parkinson’s patients suffer more from how they think about their illness than from their physical symptoms, a new look at daily life re…
Florzolotau PET shows tau accumulation patterns and links to progression in progressive supranuclear palsy
New Scan Tracks PSP Brain Changes Year by Year
This longitudinal observational study evaluated florzolotau (18F) PET imaging in 26 patients with progressive supranuclear palsy and 10 heal…
A new brain scan tracks how PSP disease spreads over time to help doctors measure treatment success without waiting for symptoms to change.
Neurotransmitter-informed network damage associated with increased odds of post-stroke depressive symptoms
Why Some Stroke Survivors Develop Depression and Others Do Not
In this cohort study of 435 patients across two independent stroke cohorts, damage to specific neurotransmitter-informed networks was associ…
Stroke damage to serotonin and acetylcholine brain networks may reveal who is most likely to develop depression.
Prospective cohort study validates nomograms for post-stroke cognitive impairment risk in acute ischemic stroke patients
Stroke survivors with high cholesterol and brain shrinkage face higher cognitive risk
This prospective cohort study developed and validated standard-criteria and age-corrected nomograms to predict post-stroke cognitive impairm…
New tools predict memory and thinking problems in stroke patients based on age, cholesterol, and brain scan signs found six months after the…
Early-onset epilepsy associated with higher biomarker abnormality in older adults
Older Adults With Epilepsy Face Higher Dementia Risk, New Brain Tests Reveal
This observational study of 84 older adults with focal epilepsy examined AT(N) biomarker profiles and cognitive associations.
New brain blood tests show most older adults with epilepsy have signs of dementia risk, even without symptoms.
Study protocol for evaluating AI-based decision support in acute ischemic stroke management
New AI System Predicts Stroke Recovery Before Treatment Starts
This study protocol describes a prospective, multicenter, observational study evaluating the VALIDATE-CDSS, an AI-based clinical decision su…
Doctors could soon use AI to predict stroke recovery chances before deciding on the best treatment plan for each patient.
Auditory targeted memory reactivation during NREM sleep nap shows no effect on motor retention
Sleep sounds changed brain waves but did not fix motor memory in Parkinson's
This study investigated the effects of auditory targeted memory reactivation (TMR) during a 2-hour NREM sleep nap on motor sequence learning…
New sleep sounds changed brain waves but did not improve movement memory in Parkinson's patients, showing a gap between brain activity and r…
Patients with migration background had higher rates of delayed presentation and lower EVT rates after first-ever ischemic stroke
Why some stroke patients miss the window for life-saving treatment
This observational cohort study examined 232 patients with a first-ever ischemic stroke at a Dutch Comprehensive Stroke Center.
Imagine waking up with sudden weakness. You call 911.
Earlier salivary melatonin onset associated with respiratory symptoms in early amyotrophic lateral sclerosis
Sleep Timing Could Predict Survival in Early ALS
This prospective longitudinal observational study assessed salivary dim-light melatonin onset in 50 people living with amyotrophic lateral s…
New research suggests sleep timing predicts how fast ALS gets worse and who survives longer without extra help.
Children with autism lack auditory looming bias seen in typical development
Brain scans show autistic kids hear approaching sounds differently
This primary trial compared EEG responses to looming vs receding sounds in 3-4-year-old children with autism, sensory concerns, or typical d…
Brain scans reveal preschoolers with autism process approaching sounds differently than typical children do, pointing to unique sensory wiri…
Network meta-analysis compares pharmacological and biological therapies for amyotrophic lateral sclerosis
New ALS Therapy Combo Shows Promise For Slowing Functional Decline
This network meta-analysis synthesized data from 109 trials involving 16,353 participants to evaluate pharmacological and biological therapi…
A major analysis suggests combining cell therapy with neuroprotective drugs may help ALS patients maintain physical function longer, though …