CD30-directed therapy, JAK/STAT inhibition, and checkpoint blockade offer potential options for ALK-negative anaplastic large cell lymphoma
Newer treatment paths for young people with a rare lymphoma
This mini-review explores the biological heterogeneity and emerging therapeutic landscape of ALK-negative anaplastic large cell lymphoma in …
Doctors are looking at new ways to treat anaplastic large cell lymphoma in children and young adults using targeted therapies.
Underwater ESD achieves 99% en bloc resection for duodenal tumors, meta-analysis finds
Underwater endoscopic technique shows promise for treating duodenal tumors
This meta-analysis of 298 lesions from retrospective studies found that underwater endoscopic submucosal dissection (U-ESD) for duodenal tum…
A new underwater endoscopic method helps doctors remove duodenal tumors in one piece while keeping procedure times under an hour.
Reactive oxygen species promote tumorigenic programs and platinum-based chemotherapy resistance in high-grade serous ovarian cancer
Reactive Oxygen Species May Drive Ovarian Cancer Progression
This narrative review of 19 in vitro studies synthesizes how reactive oxygen species (ROS) drive tumor progression, metastatic potential, an…
New research explores how reactive oxygen species (ROS) may help ovarian cancer cells grow, spread, and resist common chemotherapy treatment…
PFOA exposure linked to modest kidney and breast cancer risk in meta-analysis
PFOA exposure tied to higher kidney and breast cancer risk
This meta-analysis of 34 datasets found that perfluorooctanoic acid (PFOA) exposure is associated with a modest increase in kidney cancer ri…
A new analysis links PFOA, a common chemical, to a modest rise in kidney and breast cancer risk. Liver and thyroid cancers showed no clear l…
RGS gene panel achieves 0.98 AUC for breast cancer diagnosis and risk stratification
RGS Gene Panel Shows Promise in Breast Cancer Diagnosis
This meta-analysis of genomic data from TCGA and GEO datasets identifies RGS family genes as significant biomarkers in breast cancer. An 8-g…
A new gene panel involving the RGS family may help doctors identify breast cancer risks and improve diagnostic accuracy.
Ranibizumab and bevacizumab show comparable short-term efficacy for macular edema in retinal vein occlusion
Eye Drug Comparison Shows Similar Vision Gains
This meta-analysis of 759 patients with RVO-ME found no significant difference between intravitreal ranibizumab and bevacizumab monotherapy …
Two common eye injections work equally well for swelling caused by retinal vein blockage, a new analysis finds.
CD73-adenosine axis serves as a metabolic immune checkpoint and potential target to overcome melanoma resistance
CD73 Target May Help Overcome Melanoma Treatment Resistance
This systematic review examines the role of the CD73-adenosine axis in advanced melanoma and its implications for treatment resistance. The …
New research explores how blocking the CD73-adenosine axis could help patients with advanced melanoma overcome resistance to current treatme…
Computer-aided detection shows high sensitivity and specificity for detecting colorectal polyps of all sizes
Computer aided detection shows high accuracy for colorectal polyps
This meta-analysis of 19 studies evaluates the diagnostic accuracy of computer-aided detection (CAD) for colorectal polyps. The analysis fou…
New data confirms that computer-aided detection is highly accurate at finding both large and small colorectal polyps during screenings.
Biochemical marker decline may not indicate clinical stability in intracranial growing teratoma syndrome
Tumor Markers Drop But Mass Grows: A Case Report
This case report describes two pediatric patients with suprasellar mixed germ cell tumors who experienced biochemical success despite radiol…
In two children with brain germ cell tumors, tumor markers fell sharply while the tumor itself enlarged, a rare condition called growing ter…
Clinical breast examination uptake in sub-Saharan Africa is low at 13% across pooled data
Low Clinical Breast Examination Rates Found in Sub-Saharan Africa
This meta-analysis examines the prevalence and associated factors of clinical breast examination (CBE) uptake among women in sub-Saharan Afr…
Only 13% of women in sub-Saharan Africa received clinical breast examinations, highlighting a need for better access to early cancer detecti…
Ivonescimab plus chemotherapy improves overall survival in patients with EGFR-variant nonsquamous NSCLC
Trial shows ivonescimab extends life for certain lung cancer patients
Researchers evaluated the addition of ivonescimab to pemetrexed and carboplatin chemotherapy for patients with advanced NSCLC who previously…
A new drug combination showed a significant improvement in survival rates for patients with specific types of advanced lung cancer.
Spatial patterns of glioblastoma progression following upfront chemoradiation and salvage therapy
Analysis shows where glioblastoma tumors typically grow after treatment
Researchers analyzed the spatial patterns of tumor progression in patients with glioblastoma after standard chemoradiation and subsequent sa…
New data reveals that most glioblastoma tumors grow near the original site, helping doctors better understand how the cancer spreads after r…