Lenvatinib plus pembrolizumab did not improve overall survival compared to standard of care
Trial shows lenvatinib and pembrolizumab do not improve survival
This Phase 2 randomized trial evaluated lenvatinib and pembrolizumab in 374 adults with recurrent or metastatic head and neck squamous cell …
A Phase 2 trial found that a combination of lenvatinib and pembrolizumab did not improve overall survival for patients with advanced head an…
LAMS and BFMS show higher clinical success rates than DPPS for pancreatic fluid collections
New data reveals better stent options for pancreatic fluid collections
This network meta-analysis of 38 studies included 4265 patients with pancreatic fluid collections (PFCs) to compare various drainage methods…
Different types of stents offer varying success rates and safety profiles for patients with complex drainage needs after pancreatic issues.
Circulating microRNAs and lipidomic/metabolomic biomarkers show 0.92 SROC AUC for early breast cancer detection
Blood markers show promise for early breast cancer detection
This meta-analysis of 6,935 participants evaluated the diagnostic accuracy of circulating microRNAs and lipidomic/metabolomic biomarkers in …
A new analysis of 35 studies finds that blood-based biomarkers can detect early breast cancer with high accuracy, but more research is neede…
Transsphenoidal surgery achieves 73.88% remission rate in Cushing's Disease
Factors linked to higher remission rates in Cushing's Disease surgery
A meta-analysis of 11,666 patients with Cushing's Disease found that transsphenoidal surgery yields an overall remission rate of 73.88%. Hig…
New data identifies specific surgical and imaging factors that may help doctors predict better outcomes for patients undergoing surgery for …
Daraxonrasib improves overall survival to 13.2 months in mPDAC patients compared to 6.7 months
Trial shows daraxonrasib improves survival for pancreatic cancer patients
This Phase 3 randomized trial of 500 patients with previously treated metastatic pancreatic ductal adenocarcinoma found daraxonrasib signifi…
A Phase 3 trial found that daraxonrasib significantly extended survival times for patients with specific types of metastatic pancreatic canc…
Minimally invasive pancreaticoduodenectomy reduces blood loss and hospital stay in distal cholangiocarcinoma surgery
Minimally invasive surgery shows benefits for certain bile duct cancer
This meta-analysis of retrospective cohort studies evaluates minimally invasive pancreaticoduodenectomy (MIPD) compared to open pancreaticod…
Minimally invasive surgery can reduce blood loss and hospital stays for patients undergoing surgery for distal cholangiocarcinoma.
5-ALA fluorescence-guided surgery improves gross total resection rates in patients with glioblastoma
Fluorescence guided surgery improves tumor removal for glioblastoma patients
This meta-analysis of 790 patients found that 5-ALA guided surgery significantly improved gross total resection (RR = 1.54, 95% CI: 1.16-2.0…
A special light guide helps surgeons remove more of a brain tumor while keeping patient safety and recovery rates steady.
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
DNA Methylation Tests Show High Accuracy for Cervical Cancer Triage
DNA methylation tests show promise for identifying high grade cervical cell changes
Meta-analysis of 28,977 HPV+ women finds DNA methylation markers like JAM3 and PAX1 have high diagnostic odds ratios for detecting CIN2+.
New tests looking at DNA markers can help doctors find serious cervical cell changes more accurately than some current methods.
Guselkumab, Secukinumab, and Brodalumab rank highly for PASI 75 and PASI 90 in plaque psoriasis
New data ranks different treatments for moderate to severe psoriasis
This systematic review and network meta-analysis of 27 RCTs evaluated IL-23/IL-17 inhibitors for moderate-to-severe plaque psoriasis. Guselk…
Comparing several types of biologics helps patients with plaque psoriasis find which medications rank highest for clearing skin and improvin…
Recurrent intracranial dermoid cysts may cause delayed hydrocephalus following spontaneous rupture and ventricular dissemination
New Case Report Highlights Risks of Ruptured Brain Dermoid Cysts
This narrative review and case report describe the clinical features of a ruptured, recurrent intracranial dermoid cyst. The authors highlig…
A rare case of a ruptured brain cyst highlights the risk of delayed complications like hydrocephalus after initial surgery.
Adenomatoid tumor should be considered in the differential diagnosis for testicular lesions in patients with cryptorchidism
Testicular Adenomatoid Tumor Linked to History of Cryptorchidism
This case report and literature review describes a 58-year-old man with cryptorchidism, male breast cancer, and thymic B2 thymoma who presen…
A new case report highlights a link between undescended testes and certain benign testicular tumors, helping doctors better identify similar…