EMILIN-1 shows dual tumor-suppressive and promoting roles in brain tumor biology review
Review explores dual role of EMILIN-1 protein in brain tumor biology
A systematic review of experimental data describes EMILIN-1's complex role in nervous system tumors. The protein may exert tumor-suppressive…
A protein called EMILIN-1 might slow brain tumors in some ways but could also change the immune response to help them grow faster.
AI/ML-based miRNA signatures show diagnostic potential for early breast cancer detection
Could a simple blood test help find early breast cancer with high accuracy?
A meta-analysis of 7 studies in patients with early breast cancer found AI/ML-based circulating miRNA signatures achieved a pooled AUC of 0.…
An AI blood test could spot early breast cancer in 81% of cases with 87% accuracy, but mixed study methods mean it should only help doctors …
Simulation study suggests BF-BOLD reduces overdose rates and enhances safety in Phase I trials compared to conventional designs.
Can a smarter trial design make early cancer drug tests safer and more sustainable?
This Phase I simulation study compared the Backfill Bayesian Ordered Lattice Design (BF-BOLD) against conventional Phase I trial designs. Th…
A smarter trial design reduces overdose rates and improves safety while preserving drug effectiveness during early cancer tests.
Neoadjuvant chemotherapy plus sintilimab improved response rates versus chemotherapy alone in 61 patients with triple-negative breast cancer.
Combination therapy improved response rates in a small study of triple-negative breast cancer patients.
This retrospective cohort study evaluated 61 patients with triple-negative breast cancer (TNBC) receiving neoadjuvant therapy at a single ce…
Adding the immunotherapy drug sintilimab to standard chemotherapy boosted response rates and slowed tumor growth in triple-negative breast c…
Hospitalized malignant neoplasm patients show high comorbidity burden and distinct disease patterns across 163 Chinese hospitals.
Hospitalized cancer patients in China often have other serious health conditions
This retrospective cohort study examined 107,029 hospitalized patients with malignant neoplasms across 163 hospitals in Zhanjiang, China. Th…
Hospitalized cancer patients in China often face five other serious health conditions, with rural residents, men, and those aged 65 or older…
Radiomics and AI show promise for cervical cancer radiotherapy but face validation and standardization challenges.
AI tools show promise for cervical cancer radiotherapy but need more testing
This narrative review examines the application of radiomics and artificial intelligence (AI) in precision radiotherapy for women with cervic…
AI tools show promise for cervical cancer radiotherapy but need more testing before becoming standard care for patients.
Radiotherapy associated with improved response and survival in HCC patients receiving immune-targeted therapy
Does adding radiation help some liver cancer patients respond better to their immune therapy?
A multicenter retrospective study of 238 HCC patients receiving immune-targeted therapy found radiotherapy was associated with higher object…
Adding radiation to immune therapy helped more advanced liver cancer patients see their tumors shrink and live longer compared to those who …
Pyroptosis-related gene signature predicts prognosis in triple-negative breast cancer patients.
Can a gene signature predict survival for triple-negative breast cancer patients?
This observational cohort study analyzed data from TCGA and GEO databases, validated in an independent GEO cohort and 48 clinical samples, t…
A genetic warning system in triple-negative breast cancer tumors can predict which patients face a higher risk of the cancer returning.
Sedentary time, insomnia, and weight linked to high-risk thyroid nodules in retrospective cohort
Does sitting too much or poor sleep raise your risk for dangerous thyroid nodules?
A retrospective cohort study of 164 patients with thyroid nodules found that sedentary time >2 hours/day, insomnia, and elevated weight were…
Sitting too much, poor sleep, and higher weight raise the risk for dangerous thyroid nodules, while eating a diverse diet and smaller nodule…
Epigenomic ctDNA profiling identifies PDAC subtypes and improves prognostication over tissue-based methods in metastatic disease.
Can a blood test predict pancreatic cancer subtypes better than tissue samples?
This multi-institutional cohort study evaluated epigenomic profiling of circulating tumor DNA (ctDNA) for subtyping pancreatic ductal adenoc…
A new blood test matches tissue samples and predicts patient outcomes better for metastatic pancreatic cancer, offering a hopeful step towar…
Feasibility of combining ESPEN guidelines and Ayurvedic concepts to personalize diets for cancer patients
A small feasibility study found combining Ayurveda and standard guidelines is possible for cancer patients.
This feasibility study evaluated personalized meal plans in 33 consenting adult cancer patients over 4 weeks to 6 months. Results suggested …
Personalized meals blending Ayurveda and standard cancer guidelines improved diet quantity for 33 adult cancer patients with no safety conce…
Higher county-level socio-behavioral risk associated with increased breast and prostate cancer mortality in U.S. counties.
County social factors linked to higher breast and prostate cancer death rates within racial groups
This cross-sectional review analyzed 3,141 U.S. counties stratified by race and ethnicity to examine associations between socio-behavioral d…
County-level social factors like education and housing link to higher breast and prostate cancer death rates within all racial groups studie…