Review describes biological barriers to CAR-T therapy in solid tumors and engineering strategies
Review explores challenges and potential solutions for CAR-T therapy in solid tumors
A systematic review synthesizing literature on CAR-T cell therapy for solid tumors found clinical efficacy remains modest and inconsistent d…
Solid tumors block CAR-T cells from reaching cancer, but new engineering strategies aim to overcome these barriers for better treatment.
PAI-1 inhibition shows preclinical promise; elevated levels linked to poor cancer prognosis
Could a common cancer protein become a new treatment target?
A systematic review found elevated plasminogen activator inhibitor-1 (PAI-1) levels are consistently associated with poor prognosis across s…
High levels of a protein called PAI-1 signal worse outcomes in several cancers, while early lab studies suggest blocking it could help fight…
AI-enabled approaches may predict cutaneous toxicities in cancer immunoradiotherapy
Researchers explore AI to predict skin side effects from combined cancer treatments
A systematic mini-review synthesizes emerging AI-enabled approaches for predicting and managing cutaneous toxicities in patients with advanc…
AI could predict which cancer patients face severe skin side effects from combined radiation and immunotherapy, helping avoid treatment disr…
Complete mesocolic excision with central vascular ligation improves survival in colon cancer patients
Could a more thorough colon cancer surgery help patients live longer?
A meta-analysis of 11 prospective trials including 4,575 colon cancer patients found that complete mesocolic excision with central vascular …
A more thorough colon cancer surgery improved long-term survival and reduced recurrence without increasing short-term risks, according to an…
CPAP therapy shows no significant reduction in cancer incidence among obstructive sleep apnea patients
Does treating sleep apnea with CPAP lower your cancer risk? The answer isn't clear
A meta-analysis of three RCTs in OSA patients found no statistically significant difference in cancer incidence between CPAP and control gro…
Treating sleep apnea with CPAP does not appear to markedly reduce the risk of incident cancers, according to a new analysis of three large t…
Home test kits may boost cervical cancer screening, but evidence details are lacking
Can a home test kit help more women get screened for cervical cancer?
A review of article headlines suggests home test kits may increase cervical cancer screening, but no study details, methodology, or results …
Home test kits appear to boost cervical cancer screening rates by offering a private, convenient way for women to take control of their heal…
California's COVID-19 stay-at-home order associated with affected cervical cancer screening rates
Did pandemic lockdowns cause women to miss cervical cancer screenings?
An observational report from a large Southern California health system found that cervical cancer screening rates for women aged 21-65 were …
California's pandemic lockdowns likely caused women to miss cervical cancer screenings, delaying early detection of pre-cancerous changes.
Case report describes treatment response in rare dual-lesion DLBCL with heterogeneous subtypes
Doctors describe treatment response in rare case of dual-lesion lymphoma
A case report and systematic review describes a 65-year-old female with rare dual-lesion DLBCL featuring both GCB and ABC subtypes.
Doctors treated a woman with two different rare lymphoma types in her brain and muscle, achieving stability after adjusting her chemotherapy…
Meta-analysis finds 32% higher breast cancer mortality hazard for Indigenous women despite lower incidence
Indigenous women face higher breast cancer mortality despite lower incidence rates
A systematic review and meta-analysis of 61 studies across seven countries found Indigenous women had lower breast cancer incidence but a 32…
Indigenous women have lower breast cancer rates but face a 32% higher risk of dying from the disease compared to non-Indigenous women.
Observational report examines breast cancer survival rates in US males
Study examines survival rates for men with breast cancer in the United States
An observational report examined breast cancer survival in males in the United States.
A new report describes the survival rate of males diagnosed with breast cancer in the United States.
Hypofractionated Radiotherapy Shows High Disease Control in Melanoma Brain Metastases
Can a gentler radiation schedule help control melanoma that has spread to the brain?
A retrospective single-center study of 26 patients with melanoma brain metastases found hypofractionated radiotherapy achieved 96% disease c…
A gentle radiation schedule controlled bleeding brain tumors in 100% of cases while shrinking most melanoma growths without severe side effe…
Case report describes multimodal treatment and single-cell sequencing in NF1 patient with Malignant Triton Tumor
What happens when a rare cancer returns? One young woman's story offers a clue
A case report describes a 23-year-old woman with neurofibromatosis type 1 and Malignant Triton Tumor.
A 23-year-old woman with a rare chest tumor found disease stabilization after surgery failed, using a mix of chemotherapy, targeted therapy,…