Narrative review examines driver mutations and immunotherapy response in non-small cell lung cancer
Does your lung cancer's genetic makeup change how well immune therapy works?
This narrative review explores how targetable driver gene alterations in non-small cell lung cancer (NSCLC) influence the tumor immune micro…
Lung cancer's genetic drivers actively reshape the tumor's immune environment, causing immunotherapy to work differently depending on a pati…
Extensive intraoperative peritoneal lavage after gastrectomy for gastric cancer with peritoneal cytology positivity
Can washing the belly during surgery help prevent stomach cancer from coming back?
This single-arm exploratory phase 2 trial in 13 patients with gastric cancer and positive peritoneal cytology evaluated extensive intraopera…
A thorough belly wash during stomach cancer surgery kept patients free from recurrence for 14.5 months if their fluid tests showed no cancer…
Switching therapy after rituximab resistance in AQP4-IgG+ NMOSD shows variable relapse outcomes
New Hope for Tough-to-Treat Nerve Disorder
This single-center, retrospective case series of 10 adults with AQP4-IgG+ NMOSD who were resistant to rituximab evaluated switching therapy.
Patients with a rare nerve disease who stopped responding to standard treatment found relief after switching to new therapies that prevented…
SBRT with ≥70 Gy BED10 for colorectal liver metastases shows 74.5% 1-year FFLP
Can a higher radiation dose improve tumor control in liver metastases?
This retrospective cohort study of 116 patients with colorectal liver metastases treated with stereotactic body radiation therapy (SBRT) fou…
For liver cancer spread from colorectal cancer, higher radiation doses to tumors significantly lower the risk of regrowth, while multiple tu…
Proton therapy shows dosimetric advantages over photon therapy for prostate cancer treatment
Can proton therapy spare healthy tissue better for prostate cancer patients?
This review summarizes evidence on proton therapy for prostate cancer across treatment settings.
Proton therapy spares healthy tissue better than standard radiation for prostate cancer, offering excellent disease control with low rates o…
Comparative genomic profiling of Sezary syndrome and primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Do two rare skin lymphomas hide different mutation clues for treatment?
This observational cohort study analyzed genomic data from 26 patients with Sezary syndrome and 13 with primary cutaneous CD8+ aggressive ep…
Two rare skin lymphomas share nearly identical mutation counts but differ in ERBB2 gene changes, offering new clues for personalized treatme…
Narrative review proposes theoretical applicability of plant non-cancer resistance mechanisms to animal cancer resistance
Plants Never Get Cancer — Could Their Secret Work in Humans Too?
This narrative review synthesizes current literature to propose that fundamental principles of non-cancer resistance (NHR) in plants might a…
Plants never get cancer because of a unique immune logic that scientists now propose could inspire a new way to build cancer-resistant human…
Meta-analysis shows perioperative denosumab increases local recurrence in giant cell tumor patients
A Common Bone Tumor Drug May Raise the Risk of Cancer Coming Back
This meta-analysis evaluated perioperative denosumab in 1,551 patients undergoing surgical management of giant cell tumor.
Taking a common bone tumor drug before and after surgery nearly tripled the chance of the tumor growing back in a new analysis of 1,551 pati…
Narrative review offers novel perspectives on cancer development via RMP ubiquitination targeting
Cancer Hijacks a Cellular Recycling System — Scientists Are Learning to Fight Back
This narrative review explores the role of targeting RMP ubiquitination in cancer development.
Cancer cells hijack a hidden recycling loop inside healthy cells to grow and spread, but scientists are now mapping this trick to build new …
Narrative review examines synthetic circRNA therapeutics versus mRNA and saRNA in oncology and rare diseases
A Ring-Shaped Medicine Could Last Longer Than Anything Before It
This narrative review evaluates preclinical and early translational evidence regarding synthetic (exogenous) circRNA therapeutics compared t…
A ring-shaped RNA molecule could last longer inside the body than standard medicines, potentially helping treat cancer and rare diseases.
SCOPE platform predicts outcomes for metastatic colorectal and pancreatic cancers using organoid screening
A Lab-Built Tumor Test May Predict If Cancer Drugs Will Work
This preclinical platform development study utilized a machine learning system integrating patient-derived organoids and clinical data to pr…
A platform called SCOPE uses tiny lab-grown copies of a patient's tumor to predict — before a large trial even starts — whether a cancer dru…
Decitabine versus hydroxyurea in advanced chronic myelomonocytic leukemia shows survival differences linked to baseline counts
Keeping Blood Cell Counts Low in Leukemia Predicts Who Lives Longer
This randomized controlled trial (RCT) enrolled 120 patients with advanced proliferative chronic myelomonocytic leukemia (CMML) comparing de…
In chronic myelomonacytic leukemia, keeping abnormal blood cells low after treatment predicts who lives longer than bone marrow changes alon…