GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
New drugs help people with severe mental illness lose weight safely
This systematic review and meta-analysis evaluated glucagon-like peptide-1 receptor agonists in individuals with severe mental illness who h…
New weight loss drugs work well and stay safe for people with severe mental illness who struggle with obesity and high blood sugar.
Clozapine Use Linked to Higher SARS-CoV-2 Infection Risk in Severe Mental Disorders
Clozapine users faced higher risk of severe COVID-19 in large study
A meta-analysis of 155,945 outpatients with severe mental disorders found that clozapine users had a higher rate of SARS-CoV-2 infection com…
A massive analysis of over 155,000 people found that those taking clozapine had higher rates of infection and worse outcomes from COVID-19.
Preoperative psychological factors are associated with postoperative cognitive outcomes in older adults.
Psychological factors linked to cognitive issues after surgery in older adults
This systematic review and meta-analysis examined preoperative psychological factors in older adults aged 60 years or older. The analysis in…
A large review links preoperative anxiety and stress to worse cognitive outcomes after surgery for older patients.
Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
Brain chemical levels differ in bipolar disorder compared to healthy people
This meta-analysis of 825 patients with bipolar disorder (BD) and 885 healthy controls found significantly lower circulating GDNF levels in …
A large review found lower levels of a specific brain chemical in people with bipolar disorder. This difference was clear even when comparin…
Magnetic seizure therapy non-inferior to ECT for depression with better memory outcomes
Magnetic therapy matches standard shock therapy for depression but spares memory
This randomized non-inferiority trial compared magnetic seizure therapy (MST) with right unilateral ultra-brief ECT in 239 adults with major…
A new trial shows magnetic seizure therapy works as well as standard shock therapy for depression while causing far less memory loss in adul…
Systematic review finds cannabinoids reduce agitation in severe dementia but increase sedation risk
Cannabinoids Calm Agitation But Not All Dementia Symptoms
This systematic review and meta-analysis evaluated cannabinoids for neuropsychiatric symptoms in persons with dementia. The analysis include…
Cannabinoids may calm agitation in dementia patients but do not fix all behavioral problems and can make people sleepy.
Meta-analysis finds VR distraction does not reduce pain during IUD insertion but may lower anxiety
Virtual reality fails to stop pain during IUD insertion but helps with anxiety
This systematic review and meta-analysis of 4 RCTs (n=440) found that immersive virtual reality distraction did not significantly reduce pos…
New research shows virtual reality helps women feel less anxious during IUD insertion but does not reduce their physical pain.
Values affirmation writing reduced anxiety in first-year minoritized STEM students compared to neutral writing in an RCT.
Writing Exercise Eases Anxiety in Minority STEM Students
This randomized controlled trial enrolled 69 first-year students from minoritized racial and ethnic backgrounds in STEM fields. Participants…
A brief writing exercise helped reduce anxiety and boost belonging among first-year STEM students from minoritized backgrounds.
School-based screening and intervention reduced parent-reported anxiety in children aged eight to nine years
School screening program reduced child anxiety problems after one year
This cluster-randomised trial evaluated a screening-to-intervention pathway for child anxiety in primary schools in England. The study found…
A school-based screening and support program helped more children in England become free of anxiety problems after one year compared to usua…
Text-message CBT treatment reduced generalized anxiety disorder symptoms in young adults compared to wait-list control.
Text Message Therapy Reduces Anxiety Symptoms in Young Adults
This randomized clinical trial enrolled 103 young adults with generalized anxiety disorder or major depressive disorder. Participants receiv…
A text message treatment for depression also significantly lowered anxiety symptoms in young adults compared to waiting for care.
Cariprazine showed modest weight reduction versus aripiprazole in schizophrenia patients previously treated with olanzapine.
Cariprazine shows modest weight benefit over aripiprazole in schizophrenia patients
This trial compared cariprazine to aripiprazole in patients with schizophrenia who had previously used olanzapine. While both groups improve…
A trial found cariprazine linked to slightly more weight loss than aripiprazole in people with schizophrenia, though overall differences wer…
Self-help mindfulness and CBT interventions reduce depression and anxiety in distressed students
Mindfulness Apps Help Students Reduce Depression and Anxiety Symptoms
This RCT in 335 distressed university students in China found that self-help mindfulness interventions, with or without CBT, significantly r…
A trial found that online mindfulness programs significantly reduced depression and anxiety symptoms in stressed university students compare…