Scoping review and case report describe TANGO2 spells in TANGO2 deficiency disorder
TANGO2 deficiency spells usually start in infancy and are stress-related but self-limited
A scoping review of 93 patients and a case report characterize TANGO2 spells in TANGO2 deficiency disorder.
Stress-related spells in TANGO2 deficiency start in infancy, last hours, and show no seizure activity on EEG tests.
Pharmacist-led stewardship improved antibiotic appropriateness and outcomes in adult HAP or VAP patients
Can a pharmacist-led program make antibiotic use safer and more effective for pneumonia patients?
This randomized controlled trial evaluated a pharmacist-led antimicrobial stewardship program in 699 adult patients with hospital-acquired o…
A pharmacist-led program significantly improved antibiotic prescriptions and reduced unnecessary drug exposure for pneumonia patients in a h…
TAO-TMS shows high response rates in a small naturalistic Asian treatment-resistant depression cohort compared to historical controls
Personalized TMS showed high response rates in a small Asian depression study
This study evaluated TAO-TMS, a personalized connectivity-guided accelerated iTBS protocol, in a naturalistic Asian population with treatmen…
A personalized magnetic stimulation method helped 70% of Asian patients with depression who had not responded to other treatments improve wi…
Meta-analysis finds sleep architecture differences in drug-free schizoaffective disorder patients
Drug-free schizoaffective patients show distinct sleep pattern differences compared to healthy controls and other groups
A meta-analysis of case-control studies compared polysomnographic sleep parameters in 67 drug-free schizoaffective patients against healthy …
People with schizoaffective disorder who aren't on medication sleep less, stay awake longer, and struggle to reach deep rest compared to hea…
Indian cohort study maps non-clinical eating behavior network architecture using mixed graphical models
Is your eating behavior shaped more by culture than worry about your weight?
This observational cohort study of 1,508 individuals in India utilized mixed graphical models to analyze the architecture of non-clinical ea…
In India, home life and religion drive eating habits while worry about weight acts only as a local cluster, not the main force.
ADHD symptom trajectories associated with grey matter reductions in Dutch NeuroIMAGE cohort
Do ADHD symptoms change brain structure, and does getting better make those changes worse?
This longitudinal cohort study examined grey matter development in individuals with ADHD and controls from the Dutch NeuroIMAGE cohort.
When people with ADHD show symptom improvement, their brains actually show stronger reductions in surface area and more pronounced thinning …
EEG spatial heterogeneity mapping shows more heterogeneous topography in autistic cortex
Does the brain's electrical map look different in autism, and can we see it clearly?
A cohort study of 3,767 EEG datasets and 1,198 structural MRI scans in individuals with autism spectrum conditions found that autistic corte…
A new brain scan method reveals unique electrical patterns in autism that standard tests miss, offering a clearer view of how the brain is o…
Plasma H2S levels rise with cognitive gains in schizophrenia patients on atypical antipsychotics
Could a chemical change in your blood explain why some schizophrenia treatments boost your brain power?
A prospective observational study of 25 schizophrenia patients with acute exacerbation found that two months of atypical antipsychotic treat…
Schizophrenia patients taking standard medicine saw their memory and focus improve as a specific blood chemical level rose alongside their r…
AI CBT chatbot access reduces anxiety and depression symptoms in Brazilian primary care patients
Could a chatbot ease anxiety for patients near a specific care threshold?
A quasi-experimental study of 43,287 primary care patients in Brazil found that access to an AI-powered CBT chatbot causally reduced PHQ-ADS…
Patients near a care threshold who used an AI chatbot saw real improvements in anxiety and depression over 12 weeks in Brazil.
Medication-free major depressive disorder associated with age-dependent accelerated structural brain aging compared to healthy controls
Medication-free depression linked to accelerated brain aging in older adults
This observational cross-sectional MRI analysis compared medication-free individuals with major depressive disorder in a current episode to …
Depression in older adults without medication shows accelerated brain aging, with the gap widening to nearly seven years by age 55.
Adolescent inpatients with suicidal thoughts show increased risk-taking in decision-making task
Do risky choices in teens predict suicidal thoughts, and what does this mean for prevention?
An observational study of 83 adolescent inpatients with affective disorders and 118 healthy controls found those with suicidal thoughts and …
Teens with suicidal thoughts crave risky rewards more than safe ones, a brain pattern that predicts how severe their feelings are and links …
Large language models show potential for psychosis risk assessment from clinical interview transcripts
AI language models show promise for assessing early psychosis risk from interviews
An evaluation study of 373 participants with clinical high risk for psychosis transcripts found that large language models (LLMs) achieved 8…
Large AI models correctly identified early psychosis risk 80% of the time from interview transcripts, matching human expert scores while mos…