Deucravacitinib modulates up to 2529 genes and SLE-relevant gene sets including interferon-regulated genes
Trial Shows Deucravacitinib Modulates Gene Activity in Lupus Patients
This post hoc analysis of a Phase 2 trial in 363 patients with systemic lupus erythematosus (SLE) found that deucravacitinib modulated up to…
A Phase 2 trial shows that deucravacitinib may influence specific gene sets and immune cell activity in people with systemic lupus erythemat…
Belimumab plus standard therapy shows numerically greater reductions in IgA, IgM, and anti-dsDNA antibodies
Trial Shows Belimumab May Help Manage Lupus Nephritis Symptoms
This Phase 3 randomized controlled trial of 446 adults with active lupus nephritis found that intravenous belimumab plus standard therapy re…
A Phase 3 trial identifies specific markers that may help predict how patients with lupus nephritis respond to belimumab treatment.
Upadacitinib 15 mg daily achieves DAS28-CRP ≤3.2 in 43.3% of patients versus 22.4% for adalimumab
Trial shows upadacitinib outperforms adalimumab for rheumatoid arthritis patients
This randomized controlled trial of 492 patients with rheumatoid arthritis and prior TNFi failure found upadacitinib 15 mg daily superior to…
A new trial finds that upadacitinib works better than adalimumab for people with rheumatoid arthritis who did not respond well to previous t…
Spontaneous splenic rupture occurs as a rare but life-threatening complication in enteric fever infections
Typhoid and paratyphoid infections can cause rare splenic rupture
This case report and literature review examines spontaneous splenic rupture (SSR) in patients with typhoid and paratyphoid fever. The author…
A rare but life-threatening complication of enteric fever involves the spleen rupturing on its own, requiring doctors to stay alert during t…
Higher Triglyceride-Glucose index is associated with increased risk of albuminuria in chronic kidney disease
Higher Triglyceride-Glucose Index Linked to Kidney Damage Risk
This meta-analysis of cross-sectional and cohort studies involving 59,148 patients found that a higher TyG index is significantly associated…
A high triglyceride-glucose index may serve as an early warning sign for kidney issues, specifically a condition called albuminuria.
Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
Tai Chi and Pilates May Improve Knee Osteoarthritis Symptoms
This network meta-analysis of 29 RCTs involving 2,095 participants found that specific mind-body exercises provide distinct benefits for kne…
Specific mind-body exercises like Tai Chi and Pilates may help manage pain and improve physical function for those with knee osteoarthritis.
Peer support may impact fear of disease progression and psychological symptoms in patients with glioma
Peer support may ease fear in glioma patients
This is a protocol for a systematic review and meta-analysis regarding the impact of peer support on fear of disease progression, fatigue, d…
A new meta-analysis protocol will examine whether peer support reduces fear of disease progression in glioma patients.
Corticosteroid and cyclophosphamide exposure are associated with higher mortality in Middle Eastern and North African SLE
Specific Medications Linked to Survival Rates in Lupus Patients
This meta-analysis of 3,478 adult patients in the MENA region found an all-cause mortality rate of 9.9% (95% CI: 7.2%-14.0%). While corticos…
New data identifies how specific medications and health conditions impact long-term survival for patients with systemic lupus erythematosus.
Anti-DFS70 antibodies show high specificity but low sensitivity for excluding Systemic Lupus Erythematosus
Anti-DFS70 Antibodies May Help Rule Out Systemic Lupus Erythematoma
This meta-analysis evaluates the diagnostic performance of anti-DFS70 antibodies in patients with Systemic Lupus Erythematoma (SLE). The ana…
A large analysis suggests that specific antibodies could help doctors rule out systemic lupus, though more research is needed to confirm the…
Hand-dominant joint involvement patterns associate with better clinical outcomes in early rheumatoid arthritis
Joint Involvement Patterns May Influence Rheumatoid Arthritis Treatment Success
This individual patient data meta-analysis of 1250 patients evaluated the impact of joint involvement patterns on treatment response in earl…
New research suggests that where you experience joint pain in early rheumatoid arthritis may influence how well certain medications work.
Aerobic and resistance exercise improve fatigue, physical function, and pain in systemic lupus erythematosus
Exercise Eases Fatigue and Pain in Lupus Patients
This meta-analysis of 470 adults with SLE found that aerobic, resistance, or combined exercise leads to small-to-moderate improvements in fa…
A review of 470 lupus patients finds exercise improves fatigue, pain, and mood without worsening disease activity.
Intervention Mapping framework supports development of tailored behavioral interventions for stroke survivor rehabilitation
New framework helps tailor behavior goals for stroke survivors
This systematic review of 9 studies evaluates the Intervention Mapping (IM) framework for designing behaviorally grounded programs for strok…
A structured mapping framework helps create personalized behavioral programs to improve confidence and knowledge for people recovering from …