Mucocutaneous manifestations serve as diagnostic indicators for various systemic diseases and paraneoplastic syndromes
Skin and Mouth Signs May Signal Serious Internal Diseases
This narrative review synthesizes the clinical significance of mucocutaneous signs as indicators for conditions including SLE, dermatomyosit…
Certain skin and mouth changes can serve as important clues for doctors to identify underlying conditions like lupus, infections, and metabo…
ChatGPT 5.4 demonstrates high agreement with expert consensus on hemodialysis indications in exploratory study
ChatGPT Shows Promise in Identifying Dialysis Needs
This guideline presents an exploratory observational study evaluating ChatGPT 5.4 as a decision support tool for identifying hemodialysis in…
In a small study, ChatGPT agreed with kidney experts on dialysis need in most cases, hinting at a future training role.
Avacopan Demonstrates Non-Inferiority to Prednisone Taper in Granulomatosis with Polyangiitis and Microscopic Polyangiitis
Trial shows avacopan works as well as prednisone for vasculitis
A Phase 3 trial shows avacopan maintains efficacy comparable to prednisone while significantly reducing glucocorticoid exposure for GPA and …
A new trial shows that patients with specific autoimmune conditions can achieve remission using avacopan instead of tapering off steroid med…
Mechanical loading induces innate immune reprogramming and mitochondrial danger signals in osteoarthritis models
Mechanical Loading May Influence Immune Responses in Osteoarthritis
This mini review explores the role of mechanical loading in driving innate immune reprogramming and mitochondrial stress in osteoarthritis. …
New research explores how physical loading affects immune cells and mitochondria in joints affected by osteoarthritis.
Expedited transfer does not reduce mortality in out-of-hospital cardiac arrest
Expedited Transfer Does Not Improve Survival in Cardiac Arrest
This systematic review and meta-analysis of randomized controlled trials in 1,303 adults with out-of-hospital cardiac arrest found that expe…
A review of clinical trials shows that moving patients with cardiac arrest to hospitals faster does not improve survival or neurological rec…
Structured education programs reduce HbA1c and multiple cardiometabolic risk factors in Type 2 Diabetes
Structured education programs improve health markers for Type 2 Diabetes
This meta-analysis of 49 randomized controlled trials involving 9,587 participants found that structured education programs significantly re…
Structured education programs can lower blood sugar, blood pressure, and cholesterol levels for adults living with Type 2 Diabetes.
FDA Approves Krystexxa (pegloticase) for Chronic Gout Refractory to Conventional Therapy
FDA approves new drug Krystexxa for severe chronic gout
The FDA approved Krystexxa (pegloticase) for chronic gout in adults refractory to conventional therapy. It is a PEGylated uric acid-specific…
The FDA has approved Krystexxa (pegloticase) for adults with chronic gout that hasn't improved with other treatments. It is given as an infu…
FDA Approves Saphnelo (anifrolumab) for Moderate to Severe Systemic Lupus Erythematosus
FDA approves new lupus drug Saphnelo for adults with moderate to severe disease.
The FDA approved Saphnelo (anifrolumab) for adult patients with moderate to severe systemic lupus erythematosus (SLE) receiving standard the…
The FDA has approved Saphnelo (anifrolumab) for adults with moderate to severe systemic lupus erythematosus (SLE) who are already on standar…
Photobiomodulation protocol aims to consolidate preclinical evidence for ophthalmic diseases
Planning to Review Light Therapy for Common Eye Diseases and Injuries
This is a protocol for a systematic review and meta-analysis, not a completed study. It outlines plans to evaluate photobiomodulation (PBM) …
Experts are planning a large review to see if light therapy can help treat common eye problems like glaucoma and vision loss.
Meta-analysis identifies 101 genetic risk loci including 12 novel sites for systemic lupus erythematosus
Genetic study finds 12 new lupus risk genes
This meta-analysis of multi-ancestry individuals identified 101 risk loci, including 12 novel ones, associated with systemic lupus erythemat…
A large genetic study uncovered 12 new lupus risk genes, offering clues for future treatments and drug repurposing.
Preoperative exercise-based prehabilitation reduces postoperative pulmonary complications and hospital stay after lung cancer surgery
Exercise Before Surgery May Reduce Lung Cancer Complications
This systematic review and meta-analysis of 29 randomized controlled trials involving 2,900 participants found that preoperative exercise-ba…
Preoperative exercise programs may lower the risk of lung complications and shorten hospital stays for patients undergoing lung cancer surge…
Circulating galectin-3 levels are significantly higher in patients with systemic lupus erythematosus
Higher levels of galectin-3 found in patients with lupus
This meta-analysis of 397 SLE patients and 433 controls found that circulating Gal-3 levels were significantly higher in the SLE group (SMD …
New data shows that people with systemic lupus erythematosus have significantly higher levels of a protein called galectin-3 than healthy in…