Integrated haemotherapeutic systems improve transfusion safety and sustainability for sickle cell disease patients in Africa
New strategies aim to improve blood safety for sickle cell disease
This narrative review synthesizes current challenges and proposed solutions for sickle cell disease haemotherapy in Africa. The authors argu…
Newer strategies for blood management aim to solve common problems like blood shortages and infection risks for people with sickle cell dise…
Cognitive biases and system barriers contribute to diagnostic delays in thoracic and mediastinal conditions
Factors Contributing to Delayed Diagnosis of Thoracic and Mediastinal Conditions
This narrative review examines the factors and consequences of diagnostic delays in thoracic and mediastinal conditions, including esophagea…
Identifying why doctors may delay diagnosing chest and mediastinal issues can help improve outcomes for patients with urgent injuries or tum…
Adrenalectomy for Cushing Syndrome May Resolve Levothyroxine-Dependent Hypothyroidism in Pregnancy
Pregnancy and Cushing syndrome may hide a thyroid issue
This case report describes a 29-year-old woman at 17 weeks of gestation with Cushing syndrome and hypothyroidism who underwent retroperitone…
A pregnant woman with Cushing syndrome was able to stop taking thyroid medication after surgery to treat her hormone levels.
Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain
Ultrasound-guided nerve blocks provide relief for chronic joint pain
This narrative review synthesizes evidence on ultrasound-guided peripheral nerve blocks for refractory osteoarthritis pain. The review indic…
Newer nerve block techniques using ultrasound may offer lasting pain relief for people with severe osteoarthritis that does not respond to s…
Lateral meniscal abnormalities do not significantly impact short- to mid-term outcomes after medial UKA
Lateral Meniscus Injuries May Not Affect Knee Surgery Outcomes
This meta-analysis of 1,709 patients with anteromedial osteoarthritis found that lateral meniscal abnormalities did not significantly impact…
A review of 1,709 patients suggests that certain lateral meniscus issues do not significantly impact recovery after specific knee replacemen…
FDA Approves Sohonos (palovarotene) for Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva
FDA Approves Sohonos for Rare Bone Growth Disorder
The FDA approved Sohonos (palovarotene) for reducing new heterotopic ossification volume in adults and pediatric patients with fibrodysplasi…
The FDA approved Sohonos (palovarotene) to reduce new abnormal bone growth in people with fibrodysplasia ossificans progressiva, a rare gene…
Pre-existing neutralizing antibodies against AAV vectors limit patient eligibility and impact transgene expression durability
Antibodies against AAV vectors can limit access to gene therapy
This scoping review examines seroprevalence of neutralizing and total antibodies against AAV2, AAV8, and AAV5 vectors. The review finds that…
Many people have natural antibodies that may block them from receiving certain types of gene therapy treatments.
Pulmonary rehabilitation in cervical spinal cord injury: 29 best-evidence items span 9 care domains
Pulmonary Rehabilitation Shows Potential for Cervical Spinal Cord Injury
This systematic review synthesizes best evidence on pulmonary rehabilitation for adults with cervical spinal cord injury, extracting 29 piec…
New evidence highlights how pulmonary rehabilitation programs can support breathing and lung health for adults with cervical spinal cord inj…
Higher baseline Prognostic Nutritional Index reduces mortality risk in sepsis and pneumonia patients
Nutritional status helps predict survival in patients with severe infections
This meta-analysis of 28,757 patients with infectious diseases found that higher baseline Prognostic Nutritional Index (PNI) is associated w…
A high nutritional score at the start of treatment can help doctors identify which patients with sepsis or pneumonia are at the highest risk…
Ketamine is associated with seizure reduction in refractory and super-refractory status epilepticus
Ketamine Shows Potential for Managing Refractory Status Epilepticus
This systematic review of 491 patients with RSE and SRSE indicates that ketamine-containing regimens are associated with clinically relevant…
Ketamine may help stop seizures in patients with severe, drug-resistant epilepsy, with some evidence showing high rates of seizure resolutio…
Early mobilization reduces ICU-acquired weakness and delirium in patients with acute respiratory distress syndrome
Early Movement Helps ARDS Patients in Intensive Care
This meta-analysis of 7 RCTs indicates that early mobilization in patients with acute respiratory distress syndrome (ARDS) reduces the incid…
Starting movement early in intensive care may cut weakness and confusion for ARDS patients. It also shortens time on a breathing machine.
Multi-omics biomarkers and AI integration offer potential for precision medicine in rheumatoid arthritis
New biomarkers could help personalize treatment for rheumatoid arthritis
This systematic review evaluates multi-omics biomarkers, including TAOK3 and S-adenosylmethionine, for use in rheumatoid arthritis. The find…
New markers like TAOK3 and S-adenosylmethionine could help doctors predict how patients with rheumatoid arthritis will respond to treatment.