Phase 3
Completed N=156
Treatments for Depression: Drug Versus Psychotherapy
Source: ClinicalTrials.gov NCT00043550 ↗Enrolled (actual)
156
Serious AEs
0.0%
Results posted
Jun 2017
Primary outcomePrimary: Hamilton Rating Scale for Depression-17 Item — 19.0; 19.9; 19.4; 13.9 units on a scale — p=.95
◆ Published Evidence
Highly cited
153citations · ~5 / year
The role of avoidance and obsessiveness in matching patients to cognitive and interpersonal psychotherapy: empirical findings from the treatment for depression collaborative research program.
Summary
This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
Linked Publications (5)
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The role of avoidance and obsessiveness in matching patients to cognitive and interpersonal psychotherapy: empirical findings from the treatment for depression collaborative research program.
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Reducing Dropout in Treatment for Depression: Translating Dropout Predictors Into Individualized Treatment Recommendations.
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The Multitheoretical List of Therapeutic Interventions - 30 items (MULTI-30).
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Differential effects of alliance and techniques on Panic-Specific Reflective Function and misinterpretation of bodily sensations in two treatments for panic.
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Therapeutic immediacy in psychodynamic psychotherapy for depression: A mixed-method study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Hamilton Rating Scale for Depression-17 Item |
19.0; 19.9; 19.4; 13.9; 12.5; 12.7 | .95 |
Eligibility Criteria
Inclusion criteria
- Major Depressive Disorder diagnosis
Exclusion criteria
- Psychotic or bipolar disorder diagnosis
- Substance dependence in the last 6 months
Data sourced from ClinicalTrials.gov (NCT00043550) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.