Phase 4
Completed N=491
Research Evaluating the Value of Augmenting Medication With Psychotherapy
Source: ClinicalTrials.gov NCT00057551 ↗Enrolled (actual)
491
Serious AEs
0.0%
Results posted
Jun 2016
Primary outcomePrimary: Remission — 38.5; 31.0; 39.5 percentage of participants
◆ Published Evidence
Highly cited
213citations · ~13 / year
Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial.
Summary
This 24-week study, with a 12-month follow up period, will compare the effectiveness of antidepressant medication alone to the combination of psychotherapy and antidepressant medication in patients with chronic depression.
Linked Publications (4)
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Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial.
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Side Effects to Antidepressant Treatment in Patients With Depression and Comorbid Panic Disorder.
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Social problem solving and depressive symptoms over time: a randomized clinical trial of cognitive-behavioral analysis system of psychotherapy, brief supportive psychotherapy, and pharmacotherapy.
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Dysfunctional attitudes as a moderator of pharmacotherapy and psychotherapy for chronic depression.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Remission |
38.5; 31.0; 39.5 | — |
Eligibility Criteria
Inclusion Criteria
- Major depressive episode
- Depressive symptoms > 2 years without remission
- Hamilton Depression Scale (HAM-D) score > 20
- Fluent in English
Exclusion Criteria
- Psychotic disorders, bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, or eating disorder
- Serious, unstable, or terminal medical condition
- Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder
- Previous treatment with CBASP
- Previous ineffective treatment with 4 of the medication treatments used in the study
- Substance abuse
- Pregnancy
- Not willing to end other psychiatric treatment
Data sourced from ClinicalTrials.gov (NCT00057551) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.