N/A
N=453
Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery
Cardiovascular Diseases · Coronary Disease · Heart Diseases · Depression
Bottom Line
View on ClinicalTrials.gov: NCT00091962 ↗Enrolled (actual)
453
Serious AEs
0.0%
Results posted
Apr 2016
Primary outcome: Primary: Generic Mental Health-Related Quality of Life — 50.0; 46.2; 57.2 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Psychoeducation; Treatment recommendations (Behavioral); Pharmacotherapy (Drug); Usual Care (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Pittsburgh
- Primary completion
- Jun 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Generic Mental Health-Related Quality of Life |
50.0; 46.2; 57.2 | — |
| SECONDARY Hamilton Rating Scale for Depression |
9.0; 11.4; 3.8 | 0.001 sig |
| SECONDARY Generic Physical Health-Related Quality of Life |
44.0; 41.4; 48.7 | — |
| SECONDARY Disease-Specific Health-Related Quality of Life |
25.2; 21.4; 33.2 | — |
Summary
The purpose of this study is to treat depression in patients who have undergone coronary artery bypass graft (CABG).
Eligibility Criteria
Inclusion Criteria
- Recently underwent CABG (combined or redo procedure) at one of 8 Pittsburgh area study hospitals
- A PHQ score greater than 10 OR if nondepressed control, a PHQ score less than 5 at both 2 days post CABG to the date of discharge following CABG and when reassessed 2 weeks after hospital discharge
- Folstein Mini-Mental State Examination (MMSE) score greater than or equal to 24
- Able to be evaluated and treated for depression as an outpatient post CABG
- Has a household telephone
Exclusion Criteria
- Presently in treatment with a mental health specialist
- Actively suicidal
- History of psychotic illness
- History of bipolar illness according to subject self-report and past medical history
- Current alcohol dependence or other substance abuse as evidenced by chart review and the CAGE questionnaire
- Organic mood syndromes, including those secondary to medical illness or drugs
- Presence of non-cardiovascular conditions that are likely to be fatal within 1 year
- Unstable medical condition as indicated by history, physical, and/or laboratory findings
- Previous enrollment in the study cohort
- Non-English speaking, illiterate, or possessing any other communication barrier
- If nondepressed control, current or previous diagnosis or treatment of depression
Data sourced from ClinicalTrials.gov (NCT00091962). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.