Phase 4
Completed N=500
Stepped Care for Depression and Musculoskeletal Pain
Source: ClinicalTrials.gov NCT00118430 ↗Enrolled (actual)
500
Serious AEs
0.0%
Results posted
May 2017
Primary outcomePrimary: Brief Pain Inventory Interference — 5.0; 6.5; 4.6 units on a scale — p=<0.001
◆ Published Evidence
Highly cited
447citations · ~26 / year
Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial.
Summary
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
Linked Publications (2)
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Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial.
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The p4 screener: evaluation of a brief measure for assessing potential suicide risk in 2 randomized effectiveness trials of primary care and oncology patients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Brief Pain Inventory Interference |
5.0; 6.5; 4.6 | <0.001 sig |
| PRIMARY HSCL-20 Depression Severity |
1.1; 1.7; 0.8 | < 0.001 sig |
| SECONDARY Graded Chronic Pain Scale Disability Score |
52.5; 66.1; 44.8 | <0.001 sig |
| SECONDARY Primary Care Visits |
6.3; 5.9 | <0.001 sig |
Eligibility Criteria
Inclusion Criteria
- Moderate or severe pain in the back, hips, or knees for at least 3 months prior to study entry
- History of or current use of at least one medication for pain
- English-speaking
Exclusion Criteria
- Moderate to severe cognitive impairment
- Schizophrenia or other psychotic disorders
- Receiving disability benefits for pain
- Anticipated life expectancy less than 12 months
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT00118430) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.