Phase 4
Completed N=124
Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
Source: ClinicalTrials.gov NCT00177294 ↗Enrolled (actual)
124
Serious AEs
0.0%
Results posted
Mar 2011
Primary outcomePrimary: Remission — 58; 45 Percentage of participants — p=0.14
Summary
This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Remission |
58; 45 | 0.14 |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of unipolar major depression
- Hamilton Rating Scale for Depression (HRSD) (17 item) score of 15 or higher
- Speaks English
- Willing to discontinue other psychotropic medications
- Availability of family member or other caregiver
- Hearing capacity adequate to respond to a raised conversational voice
Exclusion Criteria
- Lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any psychotic disorder
- Folstein Mini-Mental Status Exam (MMSE) of 17 or lower
- Suicidal
- History of treatment non-adherence in other Center protocols
- History of documented non-response to citalopram in other Center protocols
- History of non-tolerance to escitalopram therapy
Data sourced from ClinicalTrials.gov (NCT00177294). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.