N/A
Completed N=59
Cognitive Rehabilitation in Schizophrenia
Source: ClinicalTrials.gov NCT00248794 ↗Enrolled (actual)
59
Serious AEs
6.8%
Results posted
Apr 2016
Primary outcomePrimary: Wisconsin Card Sort Percent Perseverative Errors (Standard Score) — 87.54; 87.88; 91.80 standard score units — p=<.97
Summary
The study will investigate the viability of two cognitive rehabilitation strategies to improve functional outcomes for people with schizophrenia. Many people with schizophrenia experience impairments in cognitive function which limit their abilities. These impairments have been shown to precede the onset of illness and represent a vulnerability factor which is exacerbated by emerging psychotic symptoms. These impairments affect a range of functional domains including symptom severity, work function, symptom management, treatment, and overall quality of life. Recognizing the link between cognitive impairment and function, a few clinicals and researchers have attempted to remediate cognitive impairments by providing cognitive retraining programs similar to those used in traumatic brain injured patients or adaptive skills training. Cognitive retraining involves repetitive exercises to increase elemental cognitive functions including memory, attention, psychomotor speed, planning, and cognitive flexibility. Adaptive skill training involves didactic group exercises in social skills, activities of daily living, and symptom management. Each approach has demonstrated some rehabilitation benefits. This study will investigate the effectiveness of a combination of these two approaches on outcomes in schizophrenia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Wisconsin Card Sort Percent Perseverative Errors (Standard Score) |
87.54; 87.88; 91.80 | <.97 |
| PRIMARY Bell Lysaker Emotion Recognition Test |
14.17; 13.40; 14.50 | .77 |
| PRIMARY Continuous Performance Task X/A Version |
91.31; 92.65; 92.17 | — |
| PRIMARY Hopkins Verbal Learning Test- Total Recall Variable |
36.33; 32.56; 32.90 | — |
| PRIMARY Independent Living Skills Survey |
.73; .73; .77 | — |
Eligibility Criteria
Inclusion Criteria
- Clinical diagnosis of schizophrenia or schizoaffective disorder. Between the ages of 18-65. Stable medication regime (no changes in last 30 days)Minimum of 30 days since last hospitalization. No hx of TBI
Exclusion Criteria
- Current Substance abuse, no comorbid neurological disease
Data sourced from ClinicalTrials.gov (NCT00248794). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.