Phase 3
Completed N=2,832
ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly
Aging · Healthy
Source: ClinicalTrials.gov NCT00298558 ↗
Enrolled (actual)
2,832
Serious AEs
0.0%
Results posted
Feb 2014
Primary outcomePrimary: Changes in Cognitive Abilities of Memory From Baseline to Year 10 — -10.6; -11.2; -12.7; -9.4 units on a scale — p=0.43
Summary
The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Cognitive Abilities of Memory From Baseline to Year 10 |
-10.6; -11.2; -12.7; -9.4 | 0.43 |
| PRIMARY Changes in Cognitive Abilities of Reasoning From Baseline to Year 10 |
-3.23; -0.049; -3.94; -3.04 | 0.69 |
| PRIMARY Changes in Cognitive Abilities of Speed of Processing From Baseline to Year 10 |
-144.4; -126.2; 24.3; -123.3 | 0.45 |
| PRIMARY Changes in Instrumental Activities of Daily Living (IADL) Difficulty From Baseline to Year 10 |
-3.05; -2.66; -2.34; -3.61 | <0.01 sig |
| PRIMARY Changes in Everyday Problem Solving From Baseline to Year 10 |
-6.10; -5.58; -5.98; -5.67 | 0.97 |
| PRIMARY Changes in Everyday Speed of Processing From Baseline to Year 10 |
-1.53; -1.39; -1.47; -1.42 | 0.78 |
| SECONDARY Changes in Health-related Quality of Life (HRQol), Driving Function, Health Service Use |
— | — |
| SECONDARY Examine Health, Genetic and Cognitive Moderators |
— | — |
| SECONDARY Estimate the Effects of ACTIVE Training to General Population |
— | — |
Eligibility Criteria
Inclusion Criteria
- Age 65 or older
- Mini-Mental State Examination (MMSE) score 23 or greater
- Vision scored greater than 20/50
- Minimal dependence in hygiene, bathing, and dressing
Exclusion Criteria
- Significant decline in cognitive skills, physical abilities, or functional independence
- Inability to complete study activities as evidenced by MMSE and vision scores lower than Inclusion Criteria requirement
- Diagnosis of Alzheimer's disease
- Stroke in previous 12 months
- Cancer with limited life expectance
- Current chemotherapy or radiation treatment
- Communication problems
- Planned move from study area
- Scheduling conflicts that would preclude participation in study activities
- Prior involvement in similar cognitive training studies
Data sourced from ClinicalTrials.gov (NCT00298558). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.