Phase 4 N=34 Retinol on Human Skin Aging in East Asian Descent
Intrinsic Aging of Skin
Primary: Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — 23; 21 genes
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=48 Ageing and Acute Care Physicians' Performance
Ageing
Primary: CRM Performance During First Sim Scenario Assessed by Ottawa Global Rating Scale (GRS) — -0.299 Pearson correlation coefficient — p=0.039
N/A N=223 Aging & HIV/AIDS Neurocognitive Sequelae and Functional Consequences
HIV Infections
Primary: Neuropsychological Status (i.e., Cognitive Functioning) — 0.008; .484; -.084; -.482 z-score composites of cognitive domains — p=0.001
N/A N=293 Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
Alzheimer Disease · Mild Cognitive Impairment · Long-Term Care Planning
Primary: Rate of Participant Long Term Care Planning for Alzheimer's Dementia/Memory Loss — 173 Participants — p=.6539
N/A N=71 Long-term Caloric Restriction and Cellular Aging Markers
Aging
Primary: Telomere Length — 0.96; 1.06; 1.06; 1.22 ratio
Phase 2 N=8 Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C)
Aging
Primary: Change in Microbiome — 0; 0; 0 Operational Taxonomic Unit (OTU)
N/A N=69 Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
HIV · Inflammation · Obesity
Primary: Time to Rise From a Chair 10 Times (Modified From the Original Short Physical Performance Battery) — -20; -20; -8; -10 percentage change
Phase 2 N=45 Targeting Inflammation to Treat Cardiovascular Aging
Vascular Stiffness · Endothelial Dysfunction · Diastolic Dysfunction
Primary: Carotid-femoral Pulse Wave Velocity (CFPWV) — 831.3; 785.1; 538.0; 839.6 cm/sec
N/A N=14 Muscle Capillarization and Sarcopenia
Sarcopenia
Primary: Skeletal Muscle Capillarization — 0.4; 0.2 capillaries per muscle fiber — p=0.27
N/A N=50 Aging With Long Term Physical Disabilities
Physical Disability
Primary: In-Home Occupational Performance Evaluation (I-HOPE) Activity Score — 0.73; 0.72; 0.76; 0.69 score on a scale — p=0.068
N/A N=1,377 The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
HIV Positive · Ageing
Primary: The Prevalence of Reported Aches and Pains in the Last Month Across the 3 Age Groups — 473; 224; 188 participants
Phase 2 N=38 Aging and Estrogen on Cortical Function
Memory Loss · Cognitive Changes · Postmenopausal Symptoms
Primary: Functional Magnetic Resonance Imaging (fMRI) Changes in Response to Estrogen and Aging - Dorsolateral Pre-frontal Cortex (DLPFC) — 455.8; -214.4; -348.1; 90.1 linear…
N/A N=30 Effect of Aging on Cortical Excitability and Motor Learning
Aging
Primary: Magnetic Resonance Spectroscopy — 0.41; -0.29 ppm — p=0.05
N/A N=90 Exercise Training and Glucose Metabolism in Aging
Type 2 Diabetes Mellitus · Impaired Glucose Tolerance (Prediabetes)
Primary: Baseline Glucose Utilization — 0.0062; 0.0035 µmol/kgFFM/pmol insulin/min
Phase 2 N=34 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
Aging
Primary: Immunological Responses — 8.33; 11.24 cells/mm^3 — p=0.56
N/A N=23 Dietary Nitrate and Physiological Aging
Aging
Primary: Change in Carotid Chemosensitivity Following 4 Weeks of Dietary Nitrate Supplementation and Placebo in Older Adults — -0.13; -0.05; -0.10; -0.11 L/min/%SpO2
N/A N=32 Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Anorexia of Ageing
Primary: Energy Intake Compensation — 1; 1 MJ/day
N/A N=32 Brown Adipose Tissue as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence (BATSR)
Metabolic Diseases
Primary: Collection of Imaging of BAT by Magnetic Resonance Imaging — 78.69; 82.58; 82.45 Percentage
N/A N=9 Translational Control of Anabolic Resistance in Aging Muscle
Physical Inactivity
Primary: Lean Mass — 403 grams
Phase 4 N=106 Aging Brain Changes, Executive Dysfunction and Depression
Depression
Primary: Hamilton Depression Rating Scale. — 8.09 units on a scale
N/A N=68 Blood Flow, Muscle Regeneration and Sarcopenia
Sarcopenia
Primary: Muscle Satellite Cells — 3.2; 3.2; 4.0; 3.8 Number of Pax7+ cells/muscle fiber
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
N/A N=37 Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women
Skin Diseases
Primary: Fold Change in Long Chain Fatty Acids — 1; 0.76 Fold Change in long chain fatty acids
N/A N=75 VItamin D Metabolism in SEnescent Cardiac Surgery Patients
Coronary Artery Bypass Grafting · Heart Valve Surgery
Primary: Peri- and Postoperative Time Course of Circulating 1,25-dihydroxyvitamin D in the First Postoperative Month in Cardiac Surgery Patients — 13; 4.2 percentage
N/A N=37 Fish Oil for HIV-Related Inflamm-aging and Immune Senescence
HIV Infection
Primary: Change in Markers of Immune Senescence Between Baseline Values and Values After 12 Weeks of Supplementation — 1.87; 4.22; -2.83; -1.56 percentage of cells — p=< 0.05
N/A N=50 Maintaining Cognitive Health in Aging Veterans
Healthy People Programs
Primary: Knowledge of Memory Aging Questionnaire-Revised — 19.8; 19.5 units on a scale
N/A N=63 Adaptability and Resilience in Aging Adults-2
Aging · Chronic Low-back Pain
Primary: Session-level Engagement — 6.3 score on a scale
Phase 2 N=32 Healthy Aging Through Functional Food
Glucose Intolerance · Aortic Stiffness · Vasodilation
Primary: Area Under the Curve for Oral Glucose Tolerance Test (oGGT) — 10.8; 11.0; 9.9; 10.6 mM h
N/A N=24 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly
Diabetes Mellitus, Type 2 · Insulin Resistance
Primary: Homeostasis Model Assessment Insulin Resistance (HOMA-IR) Index — 1.91; 0.84 units on a scale — p=0.001
N/A N=106 Oxytocin's Effect on Socioemotional Aging
Aging
Primary: Extent of Trust Behavior — 39.03; 44.42; 45.11; 46.06 monetary units