Phase 2
Completed N=34
Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
pleural effusion · Recurrent Non-small Cell Lung Cancer · Stage IIIB Non-small Cell Lung Cancer · Stage IV Non-small Cell Lung Cancer
Source: ClinicalTrials.gov NCT00408460 ↗
Enrolled (actual)
34
Serious AEs
41.2%
Results posted
Apr 2017
Primary outcomePrimary: Overall Response Rate (Complete and Partial Responses) as Assessed by RECIST Criteria — 11 Participants
Summary
This phase II trial is studying how well giving imatinib mesylate together with paclitaxel works in treating older patients with stage IIIB or stage IV non-small cell lung cancer. Imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving imatinib mesylate together with paclitaxel may kill more tumor cells
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overall Response Rate (Complete and Partial Responses) as Assessed by RECIST Criteria |
11 | — |
| SECONDARY Time to Tumor Progression |
3.6 | — |
| SECONDARY Overall Survival |
7.3 | — |
Eligibility Criteria
Inclusion Criteria
- Histologic or cytologic diagnosis of non-small cell lung cancer
- At least one site of measurable disease, as defined by the modified RECIST criteria
- Stage IIIB with pleural effusion or Stage IV disease; includes patients who received surgery alone for early stage disease, now in relapse with advanced disease; staging is according to the American Joint Committee on Cancer classification scheme, 6th edition
- Total bilirubin = 1500/uL
- Baseline platelet count >= 100,000/uL
- ECOG Performance Status 0, 1 or 2 at the time of informed consent
- Written, voluntary consent
- Patients with reproductive potential must use an acceptable contraceptive method, such methods include: 1) Male hormonal contraception; 2) Partner without reproductive potential, including post-menopausal status or history of tubal ligation; 3) Partner with intrauterine device (IUD) or contraceptive vaginal ring; 4) Partner takes oral contraceptive pill, wears contraceptive patch, or has contraceptive implant; 5) Routine use of barrier method, such as condoms or diaphragm, during sexual intercourse
- AST and ALT = 25% of bone marrow
- Grade III/IV congestive heart failure, as defined by NYHA criteria, or myocardial infarction within 6 months
- Any serious or uncontrolled concomitant disorder that, in the opinion of the investigator, would compromise the patient's ability to complete the study
- Patient has known chronic liver disease, e.g., diagnosis of chronic active hepatitis or cirrhosis
- Major surgery two weeks prior to study treatment
- Patient with any significant history of non-compliance to medical regimens or with inability to grant reliable informed consent
- Any condition requiring continuous administration of systemic corticosteroids
- The patient is on therapeutic anti-coagulation with warfarin
- The administration of any other anticancer agents including chemotherapy and biologic agents is NOT permitted
- The use of other concurrent investigational drugs is not allowed
- Participants in this study must avoid grapefruit juice or other grapefruit-containing products for the duration of treatment with imatinib
Data sourced from ClinicalTrials.gov (NCT00408460). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.