Clinical Trial Search

Primary: Self-Report of Difficulties in Emotion Regulation (DERS) — 101.5; 54.8; 120.5; 56.6 units on a scale — p=<0.004

Primary: Multidimensional Experiential Avoidance Questionnaire - Distress Aversion Subscale — 23.21; 23.21; 19.93; 19.93 score on a scale

Primary: Change From Baseline in the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) Total Score — -7.27; -6.25 score on a scale — p=0.2430

Primary: Change in Brain Metabolism From Baseline to Eight Weeks as Seen in PET Scan — 11.5 Standard uptake value — p=<0.05

Primary: Maternal Emotion Dysregulation — 82.35; 91.8 score on a scale — p=.002

Primary: Change From Baseline in ZANarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) Total Score at Week 10 — -8.7; -8.0; -9.2; -8.9 units on a scale — p=0.4994

Primary: Zanarini Rating Scale for Borderline Personality Disorder — 14.9; 14.9; 7.6; 6.7 score on a scale

Primary: Suicide Attempts — 2; 1; 4; 1 suicide attempt

Primary: Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and as Per Severity — 30; 56; 14; 37 Participants

Primary: Change in PINES Network Activity — 0.15; 0.14; 0.12; 012 BOLD Signal

Primary: Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) — 8.74; 5.80 Score on a scale

Primary: Suicide Events — 12; 4 suicide events

Primary: Change in Emotional Functioning - Linear — -.917; -1.25; -1.01 DERS scores/wk — p=.8

Primary: Efficacy: Difference in the CGI-S A/A From Baseline to Average of Weeks 8 to 12 — -1.47; -1.31 Scores on a scale — p=0.2266

Primary: Drop-out — 13; 20 participants

Primary: Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) — -1.22; -0.99; -0.75 units on a scale — p=.015

Primary: Body Dysmorphic Disorder Symptoms (as Measured by the BDD-YBOCS) — 32.21; 31.49; 26.92; 27.27 score on a scale — p=<.01

Primary: Change in Difficulties in Emotional Regulation Scale (Gratz & Roemner, 2004) — 1.4; 0.8 score on a scale

Primary: Feasibility as Assessed by Attendance at Sessions for Duration of Intervention (Percent of Sessions Attended) — 66.4 percentage of sessions attended

Primary: Body Dysmorphic Disorder Yale-Brown Obsessive Compulsive Scale (BDD-YBOCS) — 19.64; 18.77 units on a scale

Primary: Frequency of Binge Eating in the Past 28 Days — 16.06; 14.48; 6.26; 7.40 days

Primary: Functional Magnetic Resonance Imaging (fMRI) Blood Oxygen-level Dependent (BOLD) Signal Changes in Left Amygdala at Baseline and at the End of the Intervention — 1.62…

Primary: Treatment Completion Rates — 10 Participants

Primary: Difference in BDD Severity (BDD-YBOCS) at the End of Treatment/Waitlist Period. — 29.85; 30.85; 23.77; 27.13 score on a scale — p=<.0001

Primary: Yale Brown Obsessive Compulsive Scale (Modified for BDD) (BDD -YBOCS) (Phillips et al., 1997) — 23.47; 32.87; 21.37; 33.30 units on a scale — p=<.001

Primary: Columbia Suicide Severity Rating Scale Number of Participants Reporting Presence of Suicidal Behaviors — 1; 1; 0; 0 Participants

Primary: Post-Lithium Treatment Hamilton Depression Rating Scale (HDRS) — -44.49 Percent Change in HDRS-24 Score

Primary: Percent Weight Change — 23.0; 26.2; 23.3 percent weight change

Primary: Reductions Over Time in Anxiety Symptoms as Measured by Hamilton Anxiety Rating Scale — 14; 18.81; 11.78; 17.70 Units on scale — p=.02