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Phase 4 N=23

Does Omeprazole Decrease Intestinal Calcium Absorption?

Osteoporosis · Achlorhydria · GERD · Hip Fracture

Bottom Line

View on ClinicalTrials.gov: NCT00582972 ↗
Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcome: Primary: Change in Intestinal Calcium Absorption From Baseline to One Month — 5 percent calcium absorption

Study Design & Population

Study type
Interventional
Phase
Phase 4
Interventions
Omeprazole (Drug)
Age
Pediatric, Adult, Older Adult
Sex
Female
Sponsor
University of Wisconsin, Madison
Primary completion
Dec 2008

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Intestinal Calcium Absorption From Baseline to One Month		 5 —
SECONDARY
Change in Bone Resorption From Baseline to 1 Month		 1.9 —

Summary

The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.

Eligibility Criteria

Inclusion Criteria

  • Women at least 5 years past menopause, defined as the last date of menses

Exclusion Criteria

  • Allergy/Intolerance to orange juice
  • Allergy/Intolerance to omeprazole or other PPI therapy
  • Use of drugs that interact with omeprazole including oral anti-fungal agents, coumadin, diazepam, phenytoin & tacrolimus
  • Use of antacids, PPI or H2-blocker therapy within the past two months
  • Intestinal conditions associated with malabsorption or low gastric acid levels including Crohn's Disease, ulcerative colitis, pernicious anemia, bacterial overgrowth, celiac sprue, chronic diarrhea or use of antibiotics within the past month
  • Known Stage 4 or 5 Chronic Kidney Disease, defined as an estimated GFR <30 cc/minute
  • Use of medications known to interfere with calcium metabolism, including oral steroids or anticonvulsants
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00582972). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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