Phase 4 Completed N=23

Does Omeprazole Decrease Intestinal Calcium Absorption?

Osteoporosis · Achlorhydria · GERD · Hip Fracture

Source: ClinicalTrials.gov NCT00582972 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2013

Primary outcomePrimary: Change in Intestinal Calcium Absorption From Baseline to One Month — 5 percent calcium absorption

Summary

The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Intestinal Calcium Absorption From Baseline to One Month	5	—
SECONDARY Change in Bone Resorption From Baseline to 1 Month	1.9	—

Eligibility Criteria

Inclusion Criteria

Women at least 5 years past menopause, defined as the last date of menses

Exclusion Criteria

Allergy/Intolerance to orange juice
Allergy/Intolerance to omeprazole or other PPI therapy
Use of drugs that interact with omeprazole including oral anti-fungal agents, coumadin, diazepam, phenytoin & tacrolimus
Use of antacids, PPI or H2-blocker therapy within the past two months
Intestinal conditions associated with malabsorption or low gastric acid levels including Crohn's Disease, ulcerative colitis, pernicious anemia, bacterial overgrowth, celiac sprue, chronic diarrhea or use of antibiotics within the past month
Known Stage 4 or 5 Chronic Kidney Disease, defined as an estimated GFR <30 cc/minute
Use of medications known to interfere with calcium metabolism, including oral steroids or anticonvulsants

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Data sourced from ClinicalTrials.gov (NCT00582972). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.