Phase 2 Completed N=3 Treatment

Effects of Human Leptin Replacement

Obesity · Metabolic Syndrome · Diabetes

Source: ClinicalTrials.gov NCT00657605 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Feb 2020

Primary outcomePrimary: Change in Weight — NA lbs

Summary

This study will test the hypothesis that leptin contributes to the regulation of the dynamics of human endocrine function.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Weight	NA	—
SECONDARY Change in Glucose Levels	NA	—

Eligibility Criteria

Inclusion Criteria

Congenital leptin deficiency (these are only 3 adult individuals in the world that have been identified as leptin-naïve thus far).

Exclusion Criteria

Pregnant, trying to become pregnant, breast-feeding an infant or sexually active women, not using contraception.
Subjects with hemoglobin levels below 12 g/dl.
Subjects whose body contains a ferromagnetic implanted device that might produce a safety hazard during fMRI.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00657605). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.