Phase 2 Completed N=1 Treatment

Effects of Leptin Replacement in Children

Obesity · Metabolic Syndrome · Diabetes

Source: ClinicalTrials.gov NCT00659828 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Feb 2020

Primary outcomePrimary: Weight — NA lbs

Summary

To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.

Outcome Measures

Outcome	Result	p-value
PRIMARY Weight	NA	—
SECONDARY Glucose Levels	NA	—
SECONDARY Bone Mineral Density	NA	—

Eligibility Criteria

Inclusion Criteria

Children with a functional leptin gene mutation from a consanguineous Turkish family. Only one leptin-naïve child from this family is alive and eligible.

Exclusion Criteria

N/A

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00659828). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.