N/A
Completed N=99
fMRI Studies of Emotional Brain Circuitry in People With Major Depression
Source: ClinicalTrials.gov NCT00749125 ↗Enrolled (actual)
99
Serious AEs
0.0%
Results posted
Jul 2018
Primary outcomePrimary: Activations in Different Cortical Regions Caused by Emotionally Evocative Task — -0.021; 0.084; 0.021; -0.030 Voxels
Summary
This study will examine activation of a brain circuit that regulates emotion in depressed patients before and after treatment to see which areas of the brain are involved in chronic depression.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Activations in Different Cortical Regions Caused by Emotionally Evocative Task |
-0.021; 0.084; 0.021; -0.030; 0.072; -0.025 | — |
Eligibility Criteria
Depressed:
Inclusion Criteria
- Participant meets DSM-IV criteria for major depressive disorder
- Minimum score greater than 18 on Hamilton Depression Inventory
- Participant is right handed
- Participant speaks English
Exclusion Criteria
- Significant limitations that would interfere with testing procedures, such as uncorrected visual or hearing loss
- MRI contraindications, such as foreign metallic implants or a pacemaker
- Known primary neurological disorders, including dementia, stroke, encephalopathy, Parkinson's disease, brain tumors, multiple sclerosis, or seizure disorder
- Severe or unstable medical illness, such as a heart attack within the past 3 months, end stage cancer, or conditions or drugs that may cause depression (like systemic steroids or uncorrected hypothyroidism)
- Currently at risk for suicide
- Known allergy or hypersensitivity to escitalopram
Data sourced from ClinicalTrials.gov (NCT00749125). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.