Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
Pre-existing heart disease increases risks for kidney transplant patients
This meta-analysis of 112,416 kidney transplant recipients found that pre-existing coronary artery disease (CAD) is associated with signific…
Patients with pre-existing coronary artery disease face significantly higher risks of death and graft failure after receiving a kidney trans…
Vascular smooth muscle cell immune interactions drive remodeling across cardiovascular diseases
How blood vessel cells drive heart disease and high blood pressure
This narrative review synthesizes mechanisms of VSMC-immune interactions in atherosclerosis, hypertension, aortic aneurysms, and arteritis. …
A new review reveals how blood vessel cells change in heart disease, high blood pressure, and more.
Mechanical shear stress influences endothelial RNA methylation in atherosclerosis and pulmonary arterial hypertension
Mechanical forces on blood vessel cells may change how they repair themselves
This narrative review examines the interplay between hemodynamic shear stress and epitranscriptomic mechanisms in endothelial cells. The aut…
New review suggests blood flow forces might alter how RNA works in cells lining our vessels, potentially affecting heart and lung health.
Evolocumab reduces cardiovascular events in diabetes without known atherosclerosis
Evolocumab cuts heart events in high-risk diabetes patients
This prespecified subgroup analysis of a phase 3 RCT evaluated evolocumab added to statin therapy in 3655 high-risk patients with type 2 dia…
Adding evolocumab to statins reduced heart attacks and strokes by about 30% in high-risk diabetes patients without known heart disease.
Asparagus officinalis L. polysaccharides show proven anti-inflammatory and anti-non-alcoholic liver disease effects in a review
Asparagus compounds may help fight liver disease and other conditions
This review evaluates Asparagus officinalis L. polysaccharides (AOPs) regarding non-alcoholic liver disease, atherosclerosis, and neuritis. …
A review suggests asparagus compounds might help with liver disease, heart issues, and nerve pain. This natural plant waste could hold hidde…
Polygenic scores link to atherosclerosis and ischemic heart disease in Russian populations
Genetic markers help predict heart disease risk for Russian men and women
This meta-analysis review examines genetic predictors of atherosclerosis, ischemic heart disease, and myocardial infarction in a Russian pop…
A large study found specific genes linked to cholesterol levels in Russian people. These genetic scores can help doctors check heart disease…
GLP-1 receptor agonists reduce major adverse limb events with HR 0.59 in PAD
New analysis shows GLP-1 drugs cut stroke risk for people with leg artery disease
This systematic review and meta-analysis of over 240,000 adults with peripheral artery disease found that GLP-1 receptor agonists significan…
A large review of real-world data found GLP-1 drugs significantly reduce stroke and heart attack risk in adults with peripheral artery disea…
Review of plant-derived metabolites in atherosclerosis notes uneven evidence and assay interference
Plant compounds show promise for atherosclerosis but need more human proof
This narrative review examines plant-derived metabolites as potential agents for atherosclerosis. The authors note that current evidence rem…
Plant-derived metabolites may help with atherosclerosis, yet current lab data is uneven and needs careful human testing before becoming stan…
Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
A new enzyme target could treat many serious diseases at once
This narrative review synthesizes evidence on PAD4-mediated citrullination and PAD4-directed therapies for conditions including rheumatoid a…
A single enzyme called PAD4 helps cause many different diseases, and new medicines targeting it might finally help people with multiple cond…
Review of GLP-1RAs in Type 2 Diabetes and Atherosclerosis Mechanisms
Diabetes Drugs That May Protect Your Arteries From Clogging
This narrative review synthesizes evidence on glucagon-like peptide-1 receptor agonists (GLP-1RAs) for Type 2 Diabetes and atherosclerosis. …
A class of diabetes drugs originally designed to lower blood sugar may also protect your arteries from the dangerous buildup that leads to h…
Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
Autoimmune Disease May Fuel Heart Disease Through Shared Inflammation Pathway
This narrative review synthesizes evidence on pharmacological inhibition of peptidylarginine deiminase 4 and gasdermin pore formation in chr…
A new review explains why people with lupus and rheumatoid arthritis face higher heart risks and points to a shared inflammatory pathway tha…
Systematic review on OCLN in stroke and atherosclerosis highlights regulatory controversies
Doctors are still debating if changing a specific protein can help stop stroke or heart disease problems
This systematic review synthesizes evidence on the occludin gene in ischemic stroke, atherosclerosis, and hypertensive encephalopathy. The a…
This review looked at how a protein called OCLN might affect brain and heart health. Experts say more research is needed before we know if c…
Questions about Atherosclerosis
Are TNF pathway proteins linked to my atherosclerosis risk?
Yes, higher levels of TNF pathway proteins in your blood are linked to increased atherosclerosis and stroke risk, independent of other risk factors.
Full answer →Does having high HDL cholesterol lower my atherosclerosis risk?
High HDL cholesterol is linked to lower carotid plaque risk in some studies, but raising HDL with drugs has not consistently reduced cardiovascular events, so the relationship is complex.
Full answer →Can macrophage signatures help predict my atherosclerosis risk?
Yes, macrophage signatures are emerging as tools to predict atherosclerosis risk, but they are not yet ready for routine clinical use.
Full answer →How do soil contaminants and low nutrients affect my atherosclerosis risk?
Soil contaminants increase atherosclerosis risk by promoting oxidative stress and inflammation, while low nutrients reduce your body's defenses against artery damage.
Full answer →All Atherosclerosis Articles
- Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
- Vascular smooth muscle cell immune interactions drive remodeling across cardiovascular diseases
- Mechanical shear stress influences endothelial RNA methylation in atherosclerosis and pulmonary arterial hypertension
- Evolocumab reduces cardiovascular events in diabetes without known atherosclerosis
- Asparagus officinalis L. polysaccharides show proven anti-inflammatory and anti-non-alcoholic liver disease effects in a review
- Polygenic scores link to atherosclerosis and ischemic heart disease in Russian populations
- GLP-1 receptor agonists reduce major adverse limb events with HR 0.59 in PAD
- Review of plant-derived metabolites in atherosclerosis notes uneven evidence and assay interference
- Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
- Review of GLP-1RAs in Type 2 Diabetes and Atherosclerosis Mechanisms
- Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
- Systematic review on OCLN in stroke and atherosclerosis highlights regulatory controversies
- Narrative review links soil contaminants and micronutrient depletion to hypertension, atherosclerosis, and neurodegenerative processes
- Meta-analysis links TNF pathway proteins to ischemic stroke risk and recurrence
- Sex differences in outcomes after stroke in NVAF with ASCVD: a post hoc analysis
- CHIP mutations linked to higher lymph node metabolic activity in people with treated HIV
- Review discusses translational potential of macrophage-state signatures for atherosclerosis risk stratification and therapeutic targeting
- Retrospective cohort examines pre-amputation vascular workup phenotypes in chronic limb-threatening ischemia patients
- Female sex and high HDL-c linked to lower carotid plaque risk in a Chinese cohort
- Review of estrogen decline, diet, and microbial therapeutics for atherosclerosis in perimenopausal women
- Narrative review on dyslipidemia and erectile dysfunction pathophysiology
- Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
- Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
- Review Examines IL-32 Role in Cardiovascular Diseases and Atherosclerosis
- Narrative review explores metformin and trimetazidine in cardiovascular conditions
- IL-17A inhibition improves skin lesions and early atherosclerosis markers in psoriasis vulgaris patients
- Narrative review conceptualizes CVD as systemic immune–metabolic–inflammatory disease
- Meta-analysis finds 7% incidence of suspected carotid atheromas on dental panoramic radiographs
- Mini-review examines coronary artery calcium scoring for risk stratification and plaque progression
- CHIP mutations increase cardiovascular risk and mortality in older adults independent of traditional factors
- Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients
- Review of quercetin in metabolic diseases shows promise but lacks clinical validation
- Pre-eclampsia history associated with increased subclinical atherosclerosis markers in meta-analysis
- Systematic review identifies shared immune mechanisms and therapeutic targets across cardiovascular inflammatory diseases
- Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study
- GLP-1RAs associated with improved walking distance in diabetes with PAD, but limb event evidence uncertain