CHIP mutations linked to higher lymph node metabolic activity in people with treated HIV
CHIP Mutations Linked to Lymph Nodes Not Arteries in HIV Patients
This cohort study of 230 people with HIV ages 31-74 years found that clonal hematopoiesis of indeterminate potential (CHIP) was not associat…
New research shows HIV patients with specific gene changes have active lymph nodes but not thicker arteries yet.
Review discusses translational potential of macrophage-state signatures for atherosclerosis risk stratification and therapeutic targeting.
Macrophage states in plaque may help predict heart attack risk
This narrative review explores the translational potential of macrophage-state signatures for risk stratification, molecular imaging, and th…
A review suggests that understanding different immune cell states in artery plaque could improve how doctors assess heart disease risk and g…
Evolocumab reduces cardiovascular events in diabetes without known atherosclerosis
Evolocumab cuts heart events in high-risk diabetes patients
This prespecified subgroup analysis of a phase 3 RCT evaluated evolocumab added to statin therapy in 3655 high-risk patients with type 2 dia…
Adding evolocumab to statins reduced heart attacks and strokes by about 30% in high-risk diabetes patients without known heart disease.
Female sex and high HDL-c linked to lower carotid plaque risk in a Chinese cohort
New Tool Predicts Hidden Heart Risk Early
This retrospective cohort study of 12,391 individuals in Xinjiang, China, found that female sex and HDL-c >1.55 mmol/L were associated with …
A new scoring system can predict hidden artery plaque years before heart problems strike—especially in people over 45 or who smoke.
Review of estrogen decline, diet, and microbial therapeutics for atherosclerosis in perimenopausal women
Perimenopause Changes Your Heart Risk in Unexpected Ways
This narrative review examines the potential role of declining estrogen levels, dietary modification, microbial therapeutics, and precision …
Many women worry about heart health as they approach menopause.
Narrative review on dyslipidemia and erectile dysfunction pathophysiology
High Cholesterol May Damage Sexual Function Directly
This narrative review synthesizes evidence on dyslipidemia and erectile dysfunction. It concludes dyslipidemia contributes to ED through vas…
High blood fats may directly harm sexual function beyond just heart risks.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Review Examines IL-32 Role in Cardiovascular Diseases and Atherosclerosis
New Blood Test Could Predict Heart Disease Risk Years Earlier
This review evaluates the role of IL-32 across cardiovascular diseases, atherosclerosis, myocardial infarction, and heart failure. However, …
This research could change how doctors spot heart disease risk, giving patients more time to prevent it.
Narrative review explores metformin and trimetazidine in cardiovascular conditions
The Hidden Cell Death Process Quietly Driving Heart Disease
This narrative review examines the roles of metformin and trimetazidine in cardiovascular diseases, atherosclerosis, vascular calcification,…
A specific type of cell death driven by iron and fat damage plays a key role in multiple heart conditions, including heart failure and ather…
IL-17A inhibition improves skin lesions and early atherosclerosis markers in psoriasis vulgaris patients.
Psoriasis Is Linked to Heart Disease — and One Drug May Help Both
This retrospective cohort and prospective intervention study evaluated IL-17A inhibitors for psoriasis vulgaris and associated cardiovascula…
Psoriasis and heart disease share deep biological roots, and a specific drug may improve both conditions at once.
Narrative review conceptualizes CVD as systemic immune–metabolic–inflammatory disease.
Review suggests immune and metabolic factors drive cardiovascular disease progression
This narrative review synthesizes evidence on cardiovascular disease as a systemic immune–metabolic–inflammatory condition. It argues that i…
Immune and metabolic factors actively drive heart disease progression, offering new ways to assess risk and tailor prevention strategies.
Mini-review examines coronary artery calcium scoring for risk stratification and plaque progression
CAC scoring helps identify high-risk patients and may slow plaque growth in coronary artery disease
This mini-review synthesizes evidence on coronary artery calcium scoring for coronary artery disease risk assessment. It finds CAC scoring p…
CAC scoring identifies high-risk patients and may slow plaque growth in coronary artery disease, offering a robust way to measure heart risk…