N/A
Completed N=199
Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly
Lumbar Spondylosis · Cervical Spondylosis · Hip Osteoarthritis · Knee Osteoarthritis
Source: ClinicalTrials.gov NCT00788008 ↗
Enrolled (actual)
199
Serious AEs
0.0%
Results posted
Mar 2015
Primary outcomePrimary: Change in Neurocognitive Performance (Z-score) — .09; -.20; -.42; .01 z score
Summary
The purpose of this research is to determine if post-operative cognition will be better if the general anesthesia for surgery is done with an inhaled (gas through a breathing tube) or intravenous (medicine injected in the IV) general anesthetic technique.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Neurocognitive Performance (Z-score) |
.09; -.20; -.42; .01 | — |
Eligibility Criteria
Inclusion Criteria
- patients (aged 65 years or older) scheduled for elective spine or major joint replacement (total hip or total knee arthroplasty) at Duke University Medical Center or the Durham VA Medical Center
Exclusion Criteria
- not fluent in English and able to comprehend the English language
- have severe visual or auditory handicaps
- Carry a diagnosis of dementia or score < 18 on the Mini-Mental State Examination (MMSE) as calculated from the Modified Mini-Mental State (3MS) (see D4 below)
- have allergies to eggs, propofol, isoflurane, fentanyl, remifentanil, or pregabalin
Data sourced from ClinicalTrials.gov (NCT00788008). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.