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Home › Conditions › Hip Osteoarthritis

Hip Osteoarthritis

Part of Arthritis

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Osteoarthritis

51 trials tracked for Hip Osteoarthritis: 15 in phase 3 or 4 and 8 with published results. The most-cited published study has 154 citations.

51Trials tracked
15Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 3 Other / NA 33
  1. Phase 3 Tanezumab in Osteoarthritis Of The Hip Completed · 154 cited
  2. Phase 4 Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement Completed · 41 cited
  3. Phase 3 Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee Completed · 29 cited
  4. Phase 3 Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee Completed · 29 cited
  5. Phase 3 Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee. Completed · 28 cited
  6. Phase 3 Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 16 cited
Show 44 more trials
  1. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 12 cited
  2. Phase 3 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 6 cited
  3. Phase 4 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty Completed
  4. Phase 4 Minimal Opioid Use After Total Hip Replacement (THR) Completed
  5. Phase 4 Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" Completed
  6. Phase 3 Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty Completed
  7. Phase 3 Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee Completed
  8. Phase 3 A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Completed
  9. Phase 3 Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement Completed
  10. Phase 2 Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip Completed
  11. Phase 2 A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Completed
  12. Phase 2 Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee Completed
  13. N/A Shoe Lifts for Leg Length Inequality in Adults With Knee or Hip Symptoms Completed
  14. N/A Improving Resilience and Longevity for Workers Through Exercise Completed
  15. N/A Resilience for Older Workers With OA Through Exercise Completed
  16. N/A Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component Completed
  17. N/A MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis Completed
  18. N/A Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention Completed
  19. N/A Mini Stem DEXA (Dual Energy X-ray Absorptiometry) Completed
  20. N/A Study of Cingal® for Symptomatic Relief of Osteoarthritis of Hip Joint Completed
  21. N/A Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis) Completed
  22. N/A Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly Completed
  23. N/A Encore Revelation Hip Stem Completed
  24. N/A Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty Completed
  25. N/A Two Year Study With Robotic-Arm Assisted Hip Surgery. Completed
  26. N/A Mini Stem Radiostereometric Analysis Study Completed
  27. N/A Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA) Completed
  28. N/A Total Hip Replacement Performance & Assessment Completed
  29. N/A Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability Completed
  30. N/A OA Clinic-Community CARE Model Completed
  31. N/A Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis Completed
  32. N/A Allofit® IT With HXPE in Total Hip Arthroplasty Completed
  33. N/A Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty. Completed
  34. N/A Opioid Free and Therapy Minimized Advantages Using HANA Table for Total Hip Arthroplasty Completed
  35. N/A Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties Completed
  36. N/A VR Simulation and Basic Skills in THA Completed
  37. N/A Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture Completed
  38. N/A Pain and Sensation After Regional Anesthesia - Pilot Study Completed
  39. N/A Avenir Müller Hip Stem Post Market Surveillance Study Completed
  40. N/A A Study of the Safety and Effectiveness of Synvisc-One® (Hylan G-F 20) in Patients With Primary Osteoarthritis of the Hip Completed
  41. N/A A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform Completed
  42. N/A Backwards Walking Programme Following Hip and Knee Arthroplasty Completed
  43. N/A Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions Completed
  44. N/A Novel Text-Messaging Bot in Patients Undergoing Joint Arthroplasty Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hip Osteoarthritis: what the trials found

Several biologic and pharmacological interventions have demonstrated efficacy in managing hip osteoarthritis symptoms. Tanezumab showed significant improvements in WOMAC pain subscale scores at week 16 9 and week 24 11, as well as improvements in physical function [11, 12]. Specifically, a 2.5 mg dose of Tanezumab resulted in statistically significant reductions in WOMAC pain and physical function scores at 16 weeks compared to placebo 12.

Fasinumab demonstrated significant improvements in WOMAC pain and physical function subscale scores over 24 weeks 13 and 16 weeks 14. Notably, a higher percentage of patients treated with Fasinumab achieved at least a 30% reduction in WOMAC pain scores compared to placebo 13.

Pharmacological management includes the use of Celecoxib, which significantly reduced the number of flare events and the time to the first occurrence of an osteoarthritis flare compared to other treatments 8. NSAIDs were also shown to result in statistically significant reductions in WOMAC pain subscale scores at 16 weeks 10.

Post-operative management findings include the use of bupivacaine, which was associated with lower opioid consumption during the first three days post-operatively 6, and isobaric bupivacaine, which was associated with higher percentages of patients ambulating early after spinal anesthesia 7. Other local interventions such as ropivacaine 4 and dexamethasone 5 were evaluated in surgical contexts.

Recent results — preliminary, needs further review

  • The 'mymobility' program with Apple Watch showed high scores for hip disability and osteoarthritis outcome (HOOS, JR) in Phase II trials 1.
  • An OA Care Plan was associated with improvements in pain relief and functional gain at 6 months 2.
  • A study evaluating a specific intervention showed significant improvements in Harris Hip Scores and Oxford Hip Scores compared to baseline 3.

For the clinician treating this condition

  • Tanezumab and Fasinumab are established options for reducing WOMAC pain and improving physical function in patients with hip osteoarthritis.
  • Celecoxib is effective for reducing the frequency of flare events and decreasing time to first flare.
  • Bupivacaine and isobaric bupivacaine may support post-operative recovery by reducing opioid consumption and facilitating earlier ambulation.

AI synthesis of 14 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Robot-assisted total hip arthroplasty associated with improved leg-length accuracy and functional scores
Orthopedics & Sports Medicine Meta-analysis
Robot-assisted total hip arthroplasty associated with improved leg-length accuracy and functional scores Robots May Help Improve Accuracy in Hip Replacement Surgery
This meta-analysis compared robot-assisted total hip arthroplasty to conventional techniques in patients undergoing hip replacement. The aut…
Robotic assistance during hip replacement surgery is linked to better leg length accuracy and higher patient scores for joint function and c…
Sep 17, 2026
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
Anesthesiology & Pain Medicine Meta-analysis
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty Opioid-free Pain Management Shows Better Results for Hip Surgery Patients
This meta-analysis of 1681 patients found that opioid-free perioperative regimens resulted in lower movement and resting VAS pain scores com…
Patients undergoing hip replacement may experience less pain and fewer side effects when managed with opioid-free medication plans after sur…
Sep 6, 2026
Long Term Clinical Outcomes of Highly Cross-linked Polyethylene in Young Hip Arthroplasty Patients
Orthopedics & Sports Medicine Meta-analysis
Long Term Clinical Outcomes of Highly Cross-linked Polyethylene in Young Hip Arthroplasty Patients New hip implants show long term success for younger patients
Highly cross-linked polyethylene demonstrates exceptional durability and low wear rates in patients under 50 undergoing total hip arthroplas…
A new type of durable plastic in hip replacements shows excellent results and low wear for patients under 50 years old.
Sep 3, 2026
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Physical Medicine & Rehab RCT
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
May 1, 2026
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
Physical Medicine & Rehab Cohort
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program Good News for Knee Pain: Your Therapist Choice May Not Matter
This observational cohort study evaluated a structured rehabilitation program delivered by trained healthcare professionals to adults with h…
A new study shows the rehab program matters more than the specific therapist treating you.
medRxiv Apr 21, 2026
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty
Anesthesiology & Pain Medicine RCT
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty More Numbing Fluid Does Not Mean Less Pain
This randomized, controlled trial enrolled 40 patients undergoing primary total hip arthroplasty under spinal anesthesia.
Giving doctors more numbing medicine around the hip nerve does not help patients feel less pain after surgery.
Apr 18, 2026
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks Which hip replacement stem lasts longer and causes fewer problems?
A systematic review and meta-analysis of 51,375 stems in patients undergoing primary total hip arthroplasty found anatomic stems had the hig…
Newer hip replacement stems last longer and cause fewer problems like loosening, but they carry a higher risk of serious joint infections co…
Apr 13, 2026
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65
Orthopedics & Sports Medicine RCT
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65 Two hip implant materials show similar long-term results in younger patients after 25 years
A 25.5-year mean follow-up RCT in 250 patients under 65 undergoing bilateral THA compared ceramic-on-ceramic (C-O-C) to ceramic-on-HXLPE (C-…
After 25 years, two different hip implant materials performed equally well in younger patients with no bone loss and no fractures reported.
Apr 7, 2026

Research across Arthritis

Related studies from across the Arthritis family.

PRP shows limited structural benefit in knee osteoarthritis, with patellofemoral cartilage and bone marrow edema signals
Radiology & Imaging Meta-analysis
PRP shows limited structural benefit in knee osteoarthritis, with patellofemoral cartilage and bone marrow edema signals Platelet-rich plasma shows mixed results for knee osteoarthritis structure
This meta-analysis of 1200 patients with knee osteoarthritis found that platelet-rich plasma (PRP) was associated with greater improvement i…
New data shows platelet-rich plasma may improve specific knee cartilage areas but does not change overall structural disease progression.
Oct 24, 2026
Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets
Allergy & Immunology Sys. Review
Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets Scientists Map Immune Signals That May Drive Knee Arthritis
This narrative review examines immune-chondrocyte ligand-receptor (LR) axes in osteoarthritis, identifying cytokine, chemokine, DAMP-PRR, an…
A new review maps the immune signals that may push cartilage cells to break down in osteoarthritis, pointing to possible future treatment ta…
Frontiers Oct 23, 2026
Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis
Allergy & Immunology Sys. Review
Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis Cell interactions drive inflammation and tissue damage in osteoarthritis
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Frontiers Oct 17, 2026
Telemedicine May Improve Pain and Function in Arthritis Patients
Rheumatology Meta-analysis
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Telemedicine may improve pain, function, and quality of life in osteoarthritis and inflammatory arthritis, but evidence certainty is low.
Telemedicine shows promise in reducing pain and improving quality of life for people living with osteoarthritis and inflammatory arthritis.
Frontiers Oct 16, 2026
Metabolic stress from obesity and hyperglycemia impairs macrophage efferocytosis in osteoarthritis joint environments
Orthopedics & Sports Medicine Sys. Review
Metabolic stress from obesity and hyperglycemia impairs macrophage efferocytosis in osteoarthritis joint environments Metabolic Stress Linked to Joint Damage in Osteoarthritis
This mini review explores how metabolic stress, specifically obesity and hyperglycemia, impacts macrophage efferocytosis and joint homeostas…
New research identifies how obesity and high blood sugar may impair the body's ability to clear dead cells in joints, potentially worsening …
Frontiers Oct 14, 2026
Non-steroidal anti-inflammatory drugs are a predictably effective first-line pharmacologic therapy for canine osteoarthritis
Psychiatry Guideline
Non-steroidal anti-inflammatory drugs are a predictably effective first-line pharmacologic therapy for canine osteoarthritis New guidelines offer a multi-step plan for dog joint pain
This clinical guideline provides a consensus-driven framework for managing osteoarthritis in adult dogs. It identifies non-steroidal anti-in…
New guidelines suggest a mix of nutrition, exercise, and medication to help dogs with osteoarthritis live more comfortable lives.
Frontiers Oct 10, 2026
Cementless mobile-bearing UKA shows noninferior survivorship and clinical scores to cemented devices
Orthopedics & Sports Medicine RCT
Cementless mobile-bearing UKA shows noninferior survivorship and clinical scores to cemented devices Cementless implants show similar results to cemented knee replacements
This multicenter randomized controlled trial of 378 patients undergoing unicompartmental knee arthroplasty found that cementless mobile-bear…
A new study shows that cementless implants perform just as well as traditional cemented ones for patients with specific knee joint issues.
Oct 5, 2026
Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28
Anesthesiology & Pain Medicine Meta-analysis
Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28 Patient education combined with exercise reduces knee osteoarthritis pain
This meta-analysis evaluates the impact of patient education combined with exercise versus exercise alone for knee osteoarthritis. The analy…
Adding patient education to exercise routines can significantly lower pain for people living with knee osteoarthritis.
Oct 5, 2026
Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: Similar Outcomes, Higher Preference
Orthopedics & Sports Medicine Meta-analysis
Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: Similar Outcomes, Higher Preference Kinematic Alignment Shows Specific Patient Preference in Knee Replacement
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Patients with both knees replaced may prefer the kinematic alignment technique, even though overall surgical outcomes are similar to standar…
Oct 4, 2026
Digital support for exercise improves physical function in knee osteoarthritis patients
Rheumatology Meta-analysis
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Immune-cell activation and metabolic dysfunction may interact to influence synovial inflammation and cartilage homeostasis in osteoarthritis
Rheumatology Sys. Review
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Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain
Rheumatology Meta-analysis
Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain Ultrasound-guided nerve blocks provide relief for chronic joint pain
This narrative review synthesizes evidence on ultrasound-guided peripheral nerve blocks for refractory osteoarthritis pain. The review indic…
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Frontiers Sep 24, 2026

Questions about Hip Osteoarthritis

Can a structured rehabilitation program reduce pain for patients with hip osteoarthritis?

Yes, structured rehabilitation programs like GLA:D significantly reduce pain in hip osteoarthritis, with about half of patients reporting at least 30% pain reduction at 3 months.

Full answer →
Does total hip replacement with rehab improve hip osteoarthritis scores better than just exercise?

Total hip replacement combined with rehabilitation improves hip osteoarthritis scores significantly better than exercise alone, according to multiple randomized trials.

Full answer →