Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Hip Osteoarthritis

Hip Osteoarthritis

Part of Arthritis

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Osteoarthritis

51 trials tracked for Hip Osteoarthritis: 15 in phase 3 or 4 and 8 with published results. The most-cited published study has 149 citations.

51Trials tracked
15Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 3 Other / NA 33
  1. Phase 3 Tanezumab in Osteoarthritis Of The Hip Completed · 149 cited
  2. Phase 4 Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement Completed · 42 cited
  3. Phase 3 Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee Completed · 28 cited
  4. Phase 3 Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee. Completed · 27 cited
  5. Phase 3 Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee Completed · 27 cited
  6. Phase 3 Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 16 cited
Show 44 more trials
  1. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  2. Phase 3 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 6 cited
  3. Phase 4 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty Completed
  4. Phase 4 Minimal Opioid Use After Total Hip Replacement (THR) Completed
  5. Phase 4 Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" Completed
  6. Phase 3 Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty Completed
  7. Phase 3 Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee Completed
  8. Phase 3 A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Completed
  9. Phase 3 Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement Completed
  10. Phase 2 Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip Completed
  11. Phase 2 A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Completed
  12. Phase 2 Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee Completed
  13. N/A Shoe Lifts for Leg Length Inequality in Adults With Knee or Hip Symptoms Completed
  14. N/A Improving Resilience and Longevity for Workers Through Exercise Completed
  15. N/A Resilience for Older Workers With OA Through Exercise Completed
  16. N/A Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component Completed
  17. N/A MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis Completed
  18. N/A Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention Completed
  19. N/A Mini Stem DEXA (Dual Energy X-ray Absorptiometry) Completed
  20. N/A Study of Cingal® for Symptomatic Relief of Osteoarthritis of Hip Joint Completed
  21. N/A Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis) Completed
  22. N/A Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly Completed
  23. N/A Encore Revelation Hip Stem Completed
  24. N/A Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty Completed
  25. N/A Two Year Study With Robotic-Arm Assisted Hip Surgery. Completed
  26. N/A Mini Stem Radiostereometric Analysis Study Completed
  27. N/A Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA) Completed
  28. N/A Total Hip Replacement Performance & Assessment Completed
  29. N/A Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability Completed
  30. N/A OA Clinic-Community CARE Model Completed
  31. N/A Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis Completed
  32. N/A Allofit® IT With HXPE in Total Hip Arthroplasty Completed
  33. N/A Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty. Completed
  34. N/A Opioid Free and Therapy Minimized Advantages Using HANA Table for Total Hip Arthroplasty Completed
  35. N/A Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties Completed
  36. N/A VR Simulation and Basic Skills in THA Completed
  37. N/A Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture Completed
  38. N/A Pain and Sensation After Regional Anesthesia - Pilot Study Completed
  39. N/A Avenir Müller Hip Stem Post Market Surveillance Study Completed
  40. N/A A Study of the Safety and Effectiveness of Synvisc-One® (Hylan G-F 20) in Patients With Primary Osteoarthritis of the Hip Completed
  41. N/A A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform Completed
  42. N/A Backwards Walking Programme Following Hip and Knee Arthroplasty Completed
  43. N/A Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions Completed
  44. N/A Novel Text-Messaging Bot in Patients Undergoing Joint Arthroplasty Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hip Osteoarthritis: what the trials found

Several biologic and pharmacological interventions have demonstrated efficacy in managing hip osteoarthritis symptoms. Tanezumab showed significant improvements in WOMAC pain subscale scores at week 16 9 and week 24 11, as well as improvements in physical function [11, 12]. Specifically, a 2.5 mg dose of Tanezumab resulted in statistically significant reductions in WOMAC pain and physical function scores at 16 weeks compared to placebo 12.

Fasinumab demonstrated significant improvements in WOMAC pain and physical function subscale scores over 24 weeks 13 and 16 weeks 14. Notably, a higher percentage of patients treated with Fasinumab achieved at least a 30% reduction in WOMAC pain scores compared to placebo 13.

Pharmacological management includes the use of Celecoxib, which significantly reduced the number of flare events and the time to the first occurrence of an osteoarthritis flare compared to other treatments 8. NSAIDs were also shown to result in statistically significant reductions in WOMAC pain subscale scores at 16 weeks 10.

Post-operative management findings include the use of bupivacaine, which was associated with lower opioid consumption during the first three days post-operatively 6, and isobaric bupivacaine, which was associated with higher percentages of patients ambulating early after spinal anesthesia 7. Other local interventions such as ropivacaine 4 and dexamethasone 5 were evaluated in surgical contexts.

Recent results — preliminary, needs further review

  • The 'mymobility' program with Apple Watch showed high scores for hip disability and osteoarthritis outcome (HOOS, JR) in Phase II trials 1.
  • An OA Care Plan was associated with improvements in pain relief and functional gain at 6 months 2.
  • A study evaluating a specific intervention showed significant improvements in Harris Hip Scores and Oxford Hip Scores compared to baseline 3.

For the clinician treating this condition

  • Tanezumab and Fasinumab are established options for reducing WOMAC pain and improving physical function in patients with hip osteoarthritis.
  • Celecoxib is effective for reducing the frequency of flare events and decreasing time to first flare.
  • Bupivacaine and isobaric bupivacaine may support post-operative recovery by reducing opioid consumption and facilitating earlier ambulation.

AI synthesis of 14 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Physical Medicine & Rehab RCT
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
May 1, 2026
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
Physical Medicine & Rehab Cohort
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program Good News for Knee Pain: Your Therapist Choice May Not Matter
This observational cohort study evaluated a structured rehabilitation program delivered by trained healthcare professionals to adults with h…
A new study shows the rehab program matters more than the specific therapist treating you.
medRxiv Apr 21, 2026
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty
Anesthesiology & Pain Medicine RCT
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty More Numbing Fluid Does Not Mean Less Pain
This randomized, controlled trial enrolled 40 patients undergoing primary total hip arthroplasty under spinal anesthesia.
Giving doctors more numbing medicine around the hip nerve does not help patients feel less pain after surgery.
Apr 18, 2026
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks Which hip replacement stem lasts longer and causes fewer problems?
A systematic review and meta-analysis of 51,375 stems in patients undergoing primary total hip arthroplasty found anatomic stems had the hig…
Newer hip replacement stems last longer and cause fewer problems like loosening, but they carry a higher risk of serious joint infections co…
Apr 13, 2026
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65
Orthopedics & Sports Medicine RCT
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65 Two hip implant materials show similar long-term results in younger patients after 25 years
A 25.5-year mean follow-up RCT in 250 patients under 65 undergoing bilateral THA compared ceramic-on-ceramic (C-O-C) to ceramic-on-HXLPE (C-…
After 25 years, two different hip implant materials performed equally well in younger patients with no bone loss and no fractures reported.
Apr 7, 2026

Research across Arthritis

Related studies from across the Arthritis family.

VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
Anesthesiology & Pain Medicine Meta-analysis
VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis Virtual reality helps manage knee osteoarthritis pain and function
This systematic review and meta-analysis found that virtual reality (VR)-assisted physiotherapy significantly improves pain, physical functi…
Using virtual reality during physical therapy can provide better pain relief and improved balance for people with knee osteoarthritis.
Jul 24, 2026
Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds
Rheumatology Meta-analysis
Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds Mongolian Medicines Warm Acupuncture Shows Promise for Knee Osteoarthritis
This meta-analysis of 882 patients with knee osteoarthritis found that Mongolian medicines warm acupuncture significantly improved clinical …
A review of clinical trials suggests that Mongolian medicines warm acupuncture may improve symptoms for people with knee osteoarthritis.
Frontiers Jul 22, 2026
Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis
Orthopedics & Sports Medicine Meta-analysis
Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis Comparing Different Medications and Supplements to Manage Knee Osteoarthritis Pain
This network meta-analysis compared several interventions, including celecoxib, metformin, and krill oil, for the management of knee osteoar…
Doctors are looking at several ways to treat knee pain. This review compares drugs like celecoxib with natural options like krill oil.
Frontiers Jul 22, 2026
Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse
Oncology Sys. Review
Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse Cells' energy crisis may drive osteoarthritis cartilage collapse
This systematic review synthesizes literature regarding metabolic reprogramming in chondrocytes during osteoarthritis. The authors conclude …
Osteoarthritis may be fueled by a cellular energy crisis, not just wear and tear. A new review suggests targeting metabolism could lead to n…
Frontiers Jul 18, 2026
Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
Neurology Meta-analysis
Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty Neuromodulation Shows Promise for Managing Knee Osteoarthritis Pain
A scoping review of 23 studies (18 RCTs) found that various neuromodulation techniques (TENS, NMES, PNS, electroacupuncture, tDCS) demonstra…
Various electrical stimulation techniques may help manage pain and improve function for people living with knee osteoarthritis.
Frontiers Jul 16, 2026
Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
Rheumatology Sys. Review
Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies Gut health may play a role in osteoarthritis joint pain
This narrative review synthesizes evidence linking gut microbiota dysbiosis to osteoarthritis. Human studies show OA-associated changes in m…
New research suggests that imbalances in gut bacteria could contribute to cartilage damage and inflammation in people with osteoarthritis.
Frontiers Jul 9, 2026
Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
Anesthesiology & Pain Medicine RCT
Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge Surgeons performing nerve blocks may help patients leave hospital sooner
This randomized controlled trial of 200 patients undergoing total knee arthroplasty found no significant difference in time to discharge bet…
A new trial shows that surgeons performing specific nerve blocks for knee surgery provide similar pain relief and discharge times as anesthe…
Jul 6, 2026
AI models show high correlation with physics-based methods to predict peak knee adduction moment
Radiology & Imaging Meta-analysis
AI models show high correlation with physics-based methods to predict peak knee adduction moment Artificial intelligence predicts knee movement patterns during walking
This meta-analysis of 4 studies evaluated AI models predicting knee biomechanics in individuals with knee osteoarthritis. The analysis found…
New research shows artificial intelligence can accurately predict how the knee moves and handles pressure when people walk with osteoarthrit…
Jul 6, 2026
Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction
Orthopedics & Sports Medicine Meta-analysis
Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction ACL injuries and surgery impact long term risk of arthritis
This meta-analysis of matched cohort studies evaluates the risk of osteoarthritis in patients with chronic anterior cruciate ligament (ACL) …
People with torn ACL ligaments face higher risks of severe joint arthritis over time, especially if they undergo certain surgical procedures…
Jul 5, 2026
TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis
Anesthesiology & Pain Medicine Meta-analysis
TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis TENS Therapy May Help Manage Knee Osteoarthritis Pain
This meta-analysis of 20 RCTs indicates that transcutaneous electrical nerve stimulation (TENS) significantly reduces pain and improves musc…
A review of clinical trials suggests that TENS devices can reduce pain and improve muscle strength for people with knee osteoarthritis.
Jul 5, 2026
Second-generation bicruciate-retaining TKA shows 5.7% revision rate in meta-analysis
Orthopedics & Sports Medicine Meta-analysis
Second-generation bicruciate-retaining TKA shows 5.7% revision rate in meta-analysis New knee implant design shows low revision rate
This meta-analysis of 13 studies (1087 implants) found that second-generation bicruciate-retaining (BCR) total knee arthroplasty (TKA) had a…
A modern knee implant design had a 5.7% revision rate after 2.6 years, suggesting improved durability.
Jul 5, 2026
Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
Rheumatology Meta-analysis
Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis Tai Chi and Pilates May Improve Knee Osteoarthritis Symptoms
This network meta-analysis of 29 RCTs involving 2,095 participants found that specific mind-body exercises provide distinct benefits for kne…
Specific mind-body exercises like Tai Chi and Pilates may help manage pain and improve physical function for those with knee osteoarthritis.
Frontiers Jul 4, 2026

Questions about Hip Osteoarthritis

Can a structured rehabilitation program reduce pain for patients with hip osteoarthritis?

Yes, structured rehabilitation programs like GLA:D significantly reduce pain in hip osteoarthritis, with about half of patients reporting at least 30% pain reduction at 3 months.

Full answer →
Does total hip replacement with rehab improve hip osteoarthritis scores better than just exercise?

Total hip replacement combined with rehabilitation improves hip osteoarthritis scores significantly better than exercise alone, according to multiple randomized trials.

Full answer →