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Home › Conditions › Hip Osteoarthritis

Hip Osteoarthritis

Part of Arthritis

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Osteoarthritis

51 trials tracked for Hip Osteoarthritis: 15 in phase 3 or 4 and 8 with published results. The most-cited published study has 148 citations.

51Trials tracked
15Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 3 Other / NA 33
  1. Phase 3 Tanezumab in Osteoarthritis Of The Hip Completed · 148 cited
  2. Phase 4 Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement Completed · 40 cited
  3. Phase 3 Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee Completed · 27 cited
  4. Phase 3 Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee. Completed · 27 cited
  5. Phase 3 Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee Completed · 27 cited
  6. Phase 3 Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 12 cited
Show 44 more trials
  1. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  2. Phase 3 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 4 cited
  3. Phase 4 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty Completed
  4. Phase 4 Minimal Opioid Use After Total Hip Replacement (THR) Completed
  5. Phase 4 Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" Completed
  6. Phase 3 Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty Completed
  7. Phase 3 Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee Completed
  8. Phase 3 A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Completed
  9. Phase 3 Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement Completed
  10. Phase 2 Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip Completed
  11. Phase 2 A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Completed
  12. Phase 2 Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee Completed
  13. N/A Shoe Lifts for Leg Length Inequality in Adults With Knee or Hip Symptoms Completed
  14. N/A Improving Resilience and Longevity for Workers Through Exercise Completed
  15. N/A Resilience for Older Workers With OA Through Exercise Completed
  16. N/A Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component Completed
  17. N/A MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis Completed
  18. N/A Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention Completed
  19. N/A Mini Stem DEXA (Dual Energy X-ray Absorptiometry) Completed
  20. N/A Study of Cingal® for Symptomatic Relief of Osteoarthritis of Hip Joint Completed
  21. N/A Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis) Completed
  22. N/A Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly Completed
  23. N/A Encore Revelation Hip Stem Completed
  24. N/A Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty Completed
  25. N/A Two Year Study With Robotic-Arm Assisted Hip Surgery. Completed
  26. N/A Mini Stem Radiostereometric Analysis Study Completed
  27. N/A Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA) Completed
  28. N/A Total Hip Replacement Performance & Assessment Completed
  29. N/A Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability Completed
  30. N/A OA Clinic-Community CARE Model Completed
  31. N/A Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis Completed
  32. N/A Allofit® IT With HXPE in Total Hip Arthroplasty Completed
  33. N/A Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty. Completed
  34. N/A Opioid Free and Therapy Minimized Advantages Using HANA Table for Total Hip Arthroplasty Completed
  35. N/A Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties Completed
  36. N/A VR Simulation and Basic Skills in THA Completed
  37. N/A Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture Completed
  38. N/A Pain and Sensation After Regional Anesthesia - Pilot Study Completed
  39. N/A Avenir Müller Hip Stem Post Market Surveillance Study Completed
  40. N/A A Study of the Safety and Effectiveness of Synvisc-One® (Hylan G-F 20) in Patients With Primary Osteoarthritis of the Hip Completed
  41. N/A A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform Completed
  42. N/A Backwards Walking Programme Following Hip and Knee Arthroplasty Completed
  43. N/A Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions Completed
  44. N/A Novel Text-Messaging Bot in Patients Undergoing Joint Arthroplasty Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Physical Medicine & Rehab RCT
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
May 1, 2026
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
Physical Medicine & Rehab Cohort
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program Good News for Knee Pain: Your Therapist Choice May Not Matter
This observational cohort study evaluated a structured rehabilitation program delivered by trained healthcare professionals to adults with h…
A new study shows the rehab program matters more than the specific therapist treating you.
medRxiv Apr 21, 2026
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65
Orthopedics & Sports Medicine RCT
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65 Two hip implant materials show similar long-term results in younger patients after 25 years
A 25.5-year mean follow-up RCT in 250 patients under 65 undergoing bilateral THA compared ceramic-on-ceramic (C-O-C) to ceramic-on-HXLPE (C-…
After 25 years, two different hip implant materials performed equally well in younger patients with no bone loss and no fractures reported.
Apr 7, 2026

Research across Arthritis

Related studies from across the Arthritis family.

NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
Allergy & Immunology Sys. Review
NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration New review reveals how inflammation drives osteoarthritis joint damage
This narrative review synthesizes evidence on NF-κB signaling as a central hub integrating mechanical stress, innate immunity, and metabolic…
A new review explains how mechanical stress, immune signals, and metabolism combine to drive osteoarthritis, pointing to smarter treatments.
Frontiers Jun 7, 2026
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
Radiology & Imaging Cohort
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study New cartilage score predicts knee osteoarthritis onset and progression in study cohorts
This observational cohort study in the Osteoarthritis Initiative found that the Cartilage Thickness Score was higher in individuals who late…
A new cartilage score predicts who will develop knee osteoarthritis or need a replacement before symptoms appear.
medRxiv Jun 4, 2026
Kinematic alignment improves function and pain over mechanical alignment in robotic TKA
Orthopedics & Sports Medicine Meta-analysis
Kinematic alignment improves function and pain over mechanical alignment in robotic TKA Kinematic alignment beats mechanical in knee replacement
This meta-analysis of 1470 patients undergoing robotic-assisted total knee arthroplasty found that kinematic alignment (KA) was superior to …
A new analysis suggests aligning the knee implant to a patient's natural anatomy may lead to less pain and better function after robotic kne…
Jun 1, 2026
Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
Orthopedics & Sports Medicine Sys. Review
Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways Multi-omics approaches reveal new links between gut microbes and bone health
This narrative review synthesizes evidence that gut microbiome metabolites—SCFAs, bile acids, and tryptophan derivatives—regulate bone remod…
A narrative review suggests gut microbes may influence bone conditions like osteoporosis and osteoarthritis through specific metabolic pathw…
Frontiers May 29, 2026
Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function
Rheumatology Meta-analysis
Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function Wuqinxi exercise improves knee function and muscle strength in osteoarthritis patients
This systematic review and meta-analysis evaluated Wuqinxi (WQX) in patients with knee osteoarthritis. The analysis pooled data from 809 par…
A review of eight hundred and nine patients found that Wuqinxi exercise significantly improved knee function and muscle strength compared to…
Frontiers May 22, 2026
Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
Rheumatology Meta-analysis
Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis Curcumin shows promise for osteoarthritis pain with fewer side effects than NSAIDs
This umbrella review synthesizes evidence on curcumin formulations versus non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis.…
An umbrella review suggests curcumin may help osteoarthritis pain and function as well as NSAIDs while offering a more favorable tolerabilit…
Frontiers May 21, 2026
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Geriatrics & Aging Sys. Review
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Frontiers May 18, 2026
Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
Drug Pipeline Sys. Review
Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models Scientists found many plant chemicals that fight cancer and help diabetes in lab tests
This systematic review evaluates the bioactivity of 158 phenanthrene metabolites isolated from 53 Dendrobium taxa. The authors note that 64 …
A review of plant chemicals from Dendrobium plants shows strong activity against cancer and diabetes in lab studies. Most results come from …
Frontiers May 15, 2026
Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
Anesthesiology & Pain Medicine Meta-analysis
Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain Olive Oil Compounds Ease Knee Pain Better Than Expected
This systematic review and meta-analysis evaluated orally and/or topically administered olive-derived extracts or isolated bioactive compoun…
• Olive compounds cut knee pain modestly in studies • Helps adults with osteoarthritis or degenerative joint pain • Only three small trials …
May 8, 2026
Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
Anesthesiology & Pain Medicine RCT
Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response New Gene Test Predicts Who Gets Pain Relief From Acupuncture
This randomized trial compared verum acupuncture, sham acupuncture, celecoxib, placebo, and waiting list in 180 patients with chronic knee p…
A new gene test might help doctors know if acupuncture will actually stop your knee pain before you start treatment.
Apr 30, 2026
Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
Allergy & Immunology Sys. Review
Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data Engineered Exosomes Could Change How We Treat Knee Pain
This narrative review examines the potential of engineered exosomes for treating knee osteoarthritis.
New engineered cell parts show promise for stopping knee arthritis damage in early tests before human trials.
Frontiers Apr 29, 2026
Feasibility Review of Portable Markerless Motion Capture for Knee OA
Orthopedics & Sports Medicine
Feasibility Review of Portable Markerless Motion Capture for Knee OA New tech brings knee pain insights to real-world settings
This review of a feasibility study involving 85 individuals with knee OA examined a portable markerless motion capture system.
Scientists are using smart cameras in community centers to see how knee osteoarthritis really affects movement, revealing new paths to perso…
medRxiv Apr 29, 2026

Questions about Hip Osteoarthritis

Can a structured rehabilitation program reduce pain for patients with hip osteoarthritis?

Yes, structured rehabilitation programs like GLA:D significantly reduce pain in hip osteoarthritis, with about half of patients reporting at least 30% pain reduction at 3 months.

Full answer →
Does total hip replacement with rehab improve hip osteoarthritis scores better than just exercise?

Total hip replacement combined with rehabilitation improves hip osteoarthritis scores significantly better than exercise alone, according to multiple randomized trials.

Full answer →