Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Hip Osteoarthritis

Hip Osteoarthritis

Part of Arthritis

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Osteoarthritis

51 trials tracked for Hip Osteoarthritis: 15 in phase 3 or 4 and 8 with published results. The most-cited published study has 150 citations.

51Trials tracked
15Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 3 Other / NA 33
  1. Phase 3 Tanezumab in Osteoarthritis Of The Hip Completed · 150 cited
  2. Phase 4 Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement Completed · 44 cited
  3. Phase 3 Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee Completed · 28 cited
  4. Phase 3 Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee. Completed · 28 cited
  5. Phase 3 Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee Completed · 28 cited
  6. Phase 3 Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 16 cited
Show 44 more trials
  1. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  2. Phase 3 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 6 cited
  3. Phase 4 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty Completed
  4. Phase 4 Minimal Opioid Use After Total Hip Replacement (THR) Completed
  5. Phase 4 Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" Completed
  6. Phase 3 Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty Completed
  7. Phase 3 Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee Completed
  8. Phase 3 A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Completed
  9. Phase 3 Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement Completed
  10. Phase 2 Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip Completed
  11. Phase 2 A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Completed
  12. Phase 2 Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee Completed
  13. N/A Shoe Lifts for Leg Length Inequality in Adults With Knee or Hip Symptoms Completed
  14. N/A Improving Resilience and Longevity for Workers Through Exercise Completed
  15. N/A Resilience for Older Workers With OA Through Exercise Completed
  16. N/A Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component Completed
  17. N/A MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis Completed
  18. N/A Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention Completed
  19. N/A Mini Stem DEXA (Dual Energy X-ray Absorptiometry) Completed
  20. N/A Study of Cingal® for Symptomatic Relief of Osteoarthritis of Hip Joint Completed
  21. N/A Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis) Completed
  22. N/A Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly Completed
  23. N/A Encore Revelation Hip Stem Completed
  24. N/A Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty Completed
  25. N/A Two Year Study With Robotic-Arm Assisted Hip Surgery. Completed
  26. N/A Mini Stem Radiostereometric Analysis Study Completed
  27. N/A Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA) Completed
  28. N/A Total Hip Replacement Performance & Assessment Completed
  29. N/A Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability Completed
  30. N/A OA Clinic-Community CARE Model Completed
  31. N/A Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis Completed
  32. N/A Allofit® IT With HXPE in Total Hip Arthroplasty Completed
  33. N/A Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty. Completed
  34. N/A Opioid Free and Therapy Minimized Advantages Using HANA Table for Total Hip Arthroplasty Completed
  35. N/A Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties Completed
  36. N/A VR Simulation and Basic Skills in THA Completed
  37. N/A Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture Completed
  38. N/A Pain and Sensation After Regional Anesthesia - Pilot Study Completed
  39. N/A Avenir Müller Hip Stem Post Market Surveillance Study Completed
  40. N/A A Study of the Safety and Effectiveness of Synvisc-One® (Hylan G-F 20) in Patients With Primary Osteoarthritis of the Hip Completed
  41. N/A A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform Completed
  42. N/A Backwards Walking Programme Following Hip and Knee Arthroplasty Completed
  43. N/A Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions Completed
  44. N/A Novel Text-Messaging Bot in Patients Undergoing Joint Arthroplasty Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hip Osteoarthritis: what the trials found

Several biologic and pharmacological interventions have demonstrated efficacy in managing hip osteoarthritis symptoms. Tanezumab showed significant improvements in WOMAC pain subscale scores at week 16 9 and week 24 11, as well as improvements in physical function [11, 12]. Specifically, a 2.5 mg dose of Tanezumab resulted in statistically significant reductions in WOMAC pain and physical function scores at 16 weeks compared to placebo 12.

Fasinumab demonstrated significant improvements in WOMAC pain and physical function subscale scores over 24 weeks 13 and 16 weeks 14. Notably, a higher percentage of patients treated with Fasinumab achieved at least a 30% reduction in WOMAC pain scores compared to placebo 13.

Pharmacological management includes the use of Celecoxib, which significantly reduced the number of flare events and the time to the first occurrence of an osteoarthritis flare compared to other treatments 8. NSAIDs were also shown to result in statistically significant reductions in WOMAC pain subscale scores at 16 weeks 10.

Post-operative management findings include the use of bupivacaine, which was associated with lower opioid consumption during the first three days post-operatively 6, and isobaric bupivacaine, which was associated with higher percentages of patients ambulating early after spinal anesthesia 7. Other local interventions such as ropivacaine 4 and dexamethasone 5 were evaluated in surgical contexts.

Recent results — preliminary, needs further review

  • The 'mymobility' program with Apple Watch showed high scores for hip disability and osteoarthritis outcome (HOOS, JR) in Phase II trials 1.
  • An OA Care Plan was associated with improvements in pain relief and functional gain at 6 months 2.
  • A study evaluating a specific intervention showed significant improvements in Harris Hip Scores and Oxford Hip Scores compared to baseline 3.

For the clinician treating this condition

  • Tanezumab and Fasinumab are established options for reducing WOMAC pain and improving physical function in patients with hip osteoarthritis.
  • Celecoxib is effective for reducing the frequency of flare events and decreasing time to first flare.
  • Bupivacaine and isobaric bupivacaine may support post-operative recovery by reducing opioid consumption and facilitating earlier ambulation.

AI synthesis of 14 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
Anesthesiology & Pain Medicine Meta-analysis
Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty Opioid-free Pain Management Shows Better Results for Hip Surgery Patients
This meta-analysis of 1681 patients found that opioid-free perioperative regimens resulted in lower movement and resting VAS pain scores com…
Patients undergoing hip replacement may experience less pain and fewer side effects when managed with opioid-free medication plans after sur…
Sep 6, 2026
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Physical Medicine & Rehab RCT
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
May 1, 2026
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
Physical Medicine & Rehab Cohort
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program Good News for Knee Pain: Your Therapist Choice May Not Matter
This observational cohort study evaluated a structured rehabilitation program delivered by trained healthcare professionals to adults with h…
A new study shows the rehab program matters more than the specific therapist treating you.
medRxiv Apr 21, 2026
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty
Anesthesiology & Pain Medicine RCT
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty More Numbing Fluid Does Not Mean Less Pain
This randomized, controlled trial enrolled 40 patients undergoing primary total hip arthroplasty under spinal anesthesia.
Giving doctors more numbing medicine around the hip nerve does not help patients feel less pain after surgery.
Apr 18, 2026
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis compares femoral stem designs in total hip arthroplasty, showing varied revision and complication risks Which hip replacement stem lasts longer and causes fewer problems?
A systematic review and meta-analysis of 51,375 stems in patients undergoing primary total hip arthroplasty found anatomic stems had the hig…
Newer hip replacement stems last longer and cause fewer problems like loosening, but they carry a higher risk of serious joint infections co…
Apr 13, 2026
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65
Orthopedics & Sports Medicine RCT
Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65 Two hip implant materials show similar long-term results in younger patients after 25 years
A 25.5-year mean follow-up RCT in 250 patients under 65 undergoing bilateral THA compared ceramic-on-ceramic (C-O-C) to ceramic-on-HXLPE (C-…
After 25 years, two different hip implant materials performed equally well in younger patients with no bone loss and no fractures reported.
Apr 7, 2026

Research across Arthritis

Related studies from across the Arthritis family.

Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
Physical Medicine & Rehab Meta-analysis
Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis Specific exercise volume and intensity may help manage knee osteoarthritis pain
This meta-analysis of 791 people with knee osteoarthritis found that moderate-intensity isotonic lower extremity resistance exercise signifi…
New research suggests that specific types of resistance exercises can help people with knee osteoarthritis manage pain and improve daily mov…
Sep 13, 2026
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
Nutrition & Obesity Medicine Meta-analysis
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators Coumarins may protect bone and joint health in several diseases
This systematic review examines the role of coumarins and their derivatives in managing musculoskeletal diseases including osteoporosis, rhe…
Coumarins and their derivatives may slow the progression of bone and joint diseases by targeting inflammation and specific cellular pathways…
Frontiers Sep 12, 2026
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
Anesthesiology & Pain Medicine RCT
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty Nerve Block Combination May Shorten Hospital Stays After Knee Surgery
A randomized trial evaluates whether an eight-nerve block technique reduces opioid consumption and hospital stay compared to standard LIA.
A new nerve block technique for knee replacement patients showed lower opioid use and shorter hospital stays compared to standard local inje…
Sep 11, 2026
Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
Radiology & Imaging Meta-analysis
Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading Deep Learning Shows Promise Grading Knee Osteoarthritis
This meta-analysis of 32 studies evaluated deep-learning (DL) algorithms for radiographic grading of knee osteoarthritis (KOA). Pooled sensi…
AI shows promise grading knee OA on X-rays, but it's not ready for early-stage detection, a new review finds.
Sep 6, 2026
Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
Anesthesiology & Pain Medicine Meta-analysis
Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis Ozone injections may reduce knee pain more than corticosteroids
This meta-analysis of 409 patients compared intra-articular ozone injections to corticosteroid injections for knee osteoarthritis. The analy…
Ozone injections could offer a more effective way to manage pain and improve movement for people living with knee osteoarthritis.
Sep 6, 2026
Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
Orthopedics & Sports Medicine Meta-analysis
Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis Gut health treatments may reduce pain for osteoarthritis patients
This meta-analysis of 18 trials involving 2,080 adults with osteoarthritis found that probiotics, prebiotics, and synbiotics significantly r…
Targeting the gut with probiotics and prebiotics may help ease pain and improve physical function for people living with osteoarthritis.
Frontiers Sep 4, 2026
Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
Orthopedics & Sports Medicine Meta-analysis
Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk Robotic assistance improves outcomes for patients with knee osteoarthritis
This systematic review and meta-analysis of 5155 patients evaluated robotic-assisted TKA using functional alignment (FA) principles. The ana…
Robotic-assisted knee replacements using functional alignment show improved movement and lower early revision risks for patients with knee o…
Sep 3, 2026
Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
Allergy & Immunology Sys. Review
Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis Tiny particles may offer new hope for osteoarthritis treatment
This systematic review examines the role of extracellular vesicles (EVs) in osteoarthritis, identifying both pathological and therapeutic EV…
Small particles called extracellular vesicles could stop the cycle of joint damage and inflammation in people with osteoarthritis.
Frontiers Sep 3, 2026
Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
Rheumatology Sys. Review
Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain Immune Signaling and Nerve Activity Drive Osteoarthritis Pain
This mini review explores the mechanisms of synovial inflammation and immune signaling in osteoarthritis. It describes how macrophages, T ce…
New research highlights how immune cells and nerve signals work together to create and amplify chronic pain in people with osteoarthritis.
Frontiers Sep 3, 2026
Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients
Physical Medicine & Rehab Meta-analysis
Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients Interactive remote rehabilitation shows mixed results for knee replacement patients
This meta-analysis of randomized controlled trials involving 2607 adults post-total knee arthroplasty found that interactive remote rehabili…
New research into interactive remote rehabilitation for knee replacements shows it may not offer significant advantages over traditional in-…
Aug 24, 2026
Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds
Drug Pipeline Meta-analysis
Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds Icariin Shows Potential to Reduce Osteoarthritis Pain in Mice
This meta-analysis of 13 preclinical studies (238 murine subjects) found that Epimedium-derived botanical metabolites, including icariin, si…
A review of studies on mice suggests that icariin, a compound from the Epimedium plant, may reduce inflammation and pain markers in osteoart…
Frontiers Aug 24, 2026
Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
Genetics & Precision Medicine Meta-analysis
Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework New genetic analysis finds 66 hidden osteoarthritis signals
This meta-analysis evaluates the use of the Trident framework and Combined-GWAS (C-GWAS) method to identify genetic markers for osteoarthrit…
A new genetic method uncovered 66 hidden osteoarthritis signals, offering fresh clues about the condition and potential new targets for trea…
medRxiv Aug 22, 2026

Questions about Hip Osteoarthritis

Can a structured rehabilitation program reduce pain for patients with hip osteoarthritis?

Yes, structured rehabilitation programs like GLA:D significantly reduce pain in hip osteoarthritis, with about half of patients reporting at least 30% pain reduction at 3 months.

Full answer →
Does total hip replacement with rehab improve hip osteoarthritis scores better than just exercise?

Total hip replacement combined with rehabilitation improves hip osteoarthritis scores significantly better than exercise alone, according to multiple randomized trials.

Full answer →