Phase 2
Completed N=34
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
Source: ClinicalTrials.gov NCT00835224 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Apr 2014
Primary outcomePrimary: Blood Pressure — 120; 112; 117; 109 mmHg
Summary
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day in persons with spinal cord injury.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Blood Pressure |
120; 112; 117; 109; 96; 109 | — |
Eligibility Criteria
Inclusion Criteria
Spinal Cord Injured Subjects:
- chronic spinal cord injury (1 year post injury) with a seated MAP of 65mmHg (almost all individuals with tetraplegia demonstrate this)
- Male or female with an age of 18 - 65 years
Control Subjects:
- Male or female with an age of 18 - 65 years
Exclusion Criteria
Spinal Cord Injured Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
Control Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
Data sourced from ClinicalTrials.gov (NCT00835224). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.