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Home › Conditions › Spinal Cord Injury

Spinal Cord Injury

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Spinal Cord Injury

99 trials tracked for Spinal Cord Injury: 18 in phase 3 or 4 and 3 with published results. The most-cited published study has 42 citations.

99Trials tracked
18Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 6 Phase 3 12 Phase 2 21 Phase 1 6 Other / NA 54
  1. Phase 3 Resistance Training and Testosterone After Spinal Cord Injury Completed · 42 cited
  2. Phase 3 Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury Completed · 18 cited
  3. Phase 3 Treatment of Post-SCI Hypotension Completed · 7 cited
  4. Phase 4 Bowel Care and Cardiovascular Function After Spinal Cord Injury Completed
  5. Phase 4 tSCI Contrast Enhanced Ultrasound Study Completed
  6. Phase 4 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed
Show 44 more trials
  1. Phase 4 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed
  2. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  3. Phase 4 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed
  4. Phase 3 Fenofibrate Treatment in SCI Completed
  5. Phase 3 Zoledronic Acid in Acute Spinal Cord Injury Completed
  6. Phase 3 Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury. Completed
  7. Phase 3 Testosterone Replacement Therapy in Chronic Spinal Cord Injury Completed
  8. Phase 3 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed
  9. Phase 3 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  10. Phase 3 Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury Completed
  11. Phase 3 Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI) Completed
  12. Phase 3 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  13. Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI) Completed
  14. Phase 2 Development of an Ergonomic Wheelchair Pushrim Completed
  15. Phase 2 Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury Completed
  16. Phase 2 Safety and Efficacy of L-NAME and Midodrine to Increase MAP Completed
  17. Phase 2 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI) Completed
  18. Phase 2 Effects of Vaporized Marijuana on Neuropathic Pain Completed
  19. Phase 2 Prevention of Bone Loss After Acute SCI by Zoledronic Acid Completed
  20. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial Completed
  21. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
  22. Phase 2 Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide Completed
  23. Phase 2 P300 Brain Computer Interface Keyboard to Operate Assistive Technology Completed
  24. Phase 2 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury Completed
  25. Phase 2 Testosterone and Long Pulse Stimulation After SCI Completed
  26. Phase 2 Neuromodulation Techniques After SCI Completed
  27. Phase 2 Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries Completed
  28. Phase 2 A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Completed
  29. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial Completed
  30. Phase 2 Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury Completed
  31. Phase 2 Multifaceted Treatment of Catheter-related Urinary Tract Infection Completed
  32. Phase 2 Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury Completed
  33. Phase 2 Enhancement of Pressure Healing With Pulsatile Lavage Completed
  34. Phase 1 Colonizing Neurogenic Bladders With Benign Flora Completed
  35. Phase 1 Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis Completed
  36. Phase 1 High Frequency SARS for Neurogenic Bladder and Bowel Emptying Completed
  37. Phase 1 Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia Completed
  38. Phase 1 Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI Completed
  39. Phase 1 Two Devices for Reflex Voiding Following Spinal Cord Injury Completed
  40. N/A Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Completed
  41. N/A Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury Completed
  42. N/A A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes Completed
  43. N/A The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury Completed
  44. N/A Powered Exoskeletons in Persons With SCI Completed

Showing the 50 most-cited and recently-updated of 99 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Spinal Cord Injury: what the trials found

Perflutren Lipid Microsphere was successfully used for intraoperative contrast-enhanced ultrasound in acute traumatic spinal cord injury in 27 participants (p<0.05) 1. Vitamin D supplementation led to changes in trabecular plate width and spacing in femur and tibia at 4.5 and 9 months 2. Lidocaine lubricant 6, neostigmine 7, ramelteon (which did not significantly reduce wakefulness after sleep onset, p=0.70, or improve subjective morning alertness, p=0.35) 8, botulinum toxin A (which did not significantly reduce pain on NRS, p=0.432) 9, teriparatide 10, testosterone patches 11, midodrine 1213, zoledronic acid 14, fenofibrate (which reduced triglyceride concentration by 40% vs 7% in controls) 15, wheelchair skills training (which improved Wheelchair Skills Test scores, p=0.001) 16, extended release beta-2 adrenergic agonist 17, L-NAME 18, testosterone transdermal system (which increased lean tissue mass, p<0.01, and resting energy expenditure, p=0.051) 19, and fampridine-SR (which showed small changes in Ashworth score, SGI, and spasm frequency/severity scores) 2021 have been studied in spinal cord injury. However, many of these interventions lack robust evidence of efficacy or have conflicting results.

For spasticity, fampridine-SR showed minimal changes in Ashworth score (-0.28 vs -0.16) and spasm frequency/severity scores (-0.13 vs 0.02) in one trial 20, and similar small changes in another (-0.19 vs -0.15) 21. For pain, botulinum toxin A did not significantly reduce NRS scores (4.50 vs 3.44, p=0.432) 9. For sleep, ramelteon did not significantly reduce WASO (72.3 vs 76.5, p=0.70) or improve morning alertness (2.86 vs 3.14, p=0.35) 8. For metabolic outcomes, fenofibrate reduced triglycerides (-40% vs 7%) 15, and testosterone transdermal system increased lean tissue mass (53.1 vs 50.5 kg, p<0.01) 19. Wheelchair skills training improved WST scores (90.4 vs 89.6, p=0.001) 16.

Recent results — preliminary, needs further review

  • EAW+SCES (exoskeleton and spinal cord epidural stimulation) was studied in 4 participants, with outcomes including percentage fat mass and fasting lipid profile reported 3.
  • Elastic assisted treadmill walking was investigated in 19 participants 4.
  • Passive heat stress was studied in 10 participants 5.

For the clinician treating this condition

  • Perflutren Lipid Microsphere is feasible for intraoperative contrast-enhanced ultrasound in acute traumatic spinal cord injury 1.
  • Fenofibrate may reduce triglyceride levels in spinal cord injury patients 15.
  • Testosterone transdermal system can increase lean tissue mass 19.
  • Wheelchair skills training improves wheelchair skills test scores 16.

AI synthesis of 21 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Exosome and extracellular vesicle therapies show promising signals for spinal cord injury repair
Neurology Meta-analysis
Exosome and extracellular vesicle therapies show promising signals for spinal cord injury repair Exosomes Show Promise in Treating Spinal Cord Injuries
This meta-analysis of 23 animal studies and 1 human phase I study evaluates exosome or extracellular vesicle interventions for spinal cord i…
New research into exosome and extracellular vesicle treatments shows potential for improving movement and tissue repair after spinal cord in…
medRxiv Jul 30, 2026
AI monitoring offers potential for continuous vital sign tracking and personalized pain management in spinal cord injury
Orthopedics & Sports Medicine Sys. Review
AI monitoring offers potential for continuous vital sign tracking and personalized pain management in spinal cord injury Artificial intelligence could improve care for spinal cord injuries
This narrative review explores the role of AI monitoring, including data acquisition and real-time analysis, for postoperative pain manageme…
New technology may help doctors track vital signs and manage pain more quickly for people with spinal cord injuries.
Frontiers Jul 24, 2026
Complete spinal cord injury and assisted ventilation significantly increase risk of hyponatremia in SCI patients
Neurology Meta-analysis
Complete spinal cord injury and assisted ventilation significantly increase risk of hyponatremia in SCI patients Specific Factors Linked to Hyponatremia in Spinal Cord Injury
This meta-analysis of 2,729 patients identifies several clinical risk factors for hyponatremia in individuals with spinal cord injury (SCI).…
Certain conditions like complete spinal cord injuries and assisted ventilation are linked to a higher risk of low sodium levels in patients.
Frontiers Jul 3, 2026
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
Neurology Sys. Review
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury Ferroptosis Linked to Spinal Cord Injury and Disc Degeneration
This mini review proposes a ferroptosis-mediated domino effect connecting intervertebral disc degeneration, spinal deformity, and spinal cor…
A new theoretical framework suggests that a specific type of cell death may link disc degeneration to spinal cord injury.
Frontiers Jun 19, 2026
Integrated vocational rehabilitation models outperform traditional approaches for patients with spinal cord injury
Physical Medicine & Rehab Sys. Review
Integrated vocational rehabilitation models outperform traditional approaches for patients with spinal cord injury Federal policies and benefits traps hinder employment for spinal cord injuries
This scoping review analyzed 10 studies to map the evidence landscape regarding federal policies and vocational rehabilitation (VR) for indi…
Hidden financial barriers and outdated support models often prevent people with spinal cord injuries from returning to the workforce in the …
Frontiers Jun 8, 2026
Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
Neurology Meta-analysis
Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models Older rats recover less from spinal cord injury, but exercise helps them catch up
This systematic review of preclinical studies found that older animals demonstrate significantly lower locomotor scores after spinal cord in…
Aging makes spinal cord injury harder to recover from in rats. But exercise training can help older animals reach recovery levels similar to…
Frontiers Jun 2, 2026
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
Neurology Meta-analysis
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury Robot training improves walking after spinal cord injury
This systematic review and meta-analysis of 241 participants with spinal cord injury found that robot-assisted gait training led to signific…
Robot-assisted gait training helps people with spinal cord injury walk farther and more independently than standard rehab alone.
Frontiers May 30, 2026
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
Hematology Sys. Review
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps NINJ1 targeting shows promise for multiple sclerosis and other brain injuries
This narrative review examines NINJ1 targeting as a therapeutic strategy for multiple sclerosis, ischemic stroke, traumatic brain injury, sp…
A review suggests NINJ1 targeting could help treat multiple sclerosis, stroke, and other brain injuries, though more research is needed.
Frontiers May 30, 2026
Atractylenolide III shows neuroprotective effects in preclinical CNS disorder models
Drug Pipeline Sys. Review
Atractylenolide III shows neuroprotective effects in preclinical CNS disorder models Atractylenolide III shows promise for brain and nerve injuries in lab models
This narrative review summarizes preclinical evidence that Atractylenolide III exerts neuroprotective effects in models of cognitive impairm…
Atractylenolide III looks like a helpful option for brain and nerve damage in early lab tests, though human trials are needed.
Frontiers May 29, 2026
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Drug Pipeline Sys. Review
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Frontiers May 25, 2026
Systematic review of neural progenitor cell transplantation for spinal cord injury
Neurology Sys. Review
Systematic review of neural progenitor cell transplantation for spinal cord injury New review shows stem cell treatments for spinal cord injury are still in early testing stages
This systematic review synthesized evidence from 19 clinical trials on neural progenitor cell transplantation for spinal cord injury. The au…
A review of nineteen trials from ten countries found that stem cells might help spinal cord injury patients recover movement. However, no tr…
Frontiers May 25, 2026
Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models
Allergy & Immunology Meta-analysis
Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models Resveratrol shows promise for spinal cord injury in animal studies
This systematic review and meta-analysis of 38 preclinical animal studies found that resveratrol significantly improved locomotor recovery a…
A review of animal studies suggests resveratrol may improve movement and reduce damage after spinal cord injury, but human trials are needed…
Frontiers May 21, 2026

Questions about Spinal Cord Injury

Is there a link between intervertebral disc degeneration and spinal cord injury?

Yes, emerging evidence suggests intervertebral disc degeneration can lead to spinal cord injury through a cascade involving ferroptosis, iron deposition, and increased vulnerability.

Full answer →
Do Canadian policies for spinal cord injury supplies rely on means-testing rather than medical need?

Yes, Canadian policies for spinal cord injury supplies often use means-testing (income-based eligibility) rather than medical need, leading to wide inequities across provinces.

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Are exosomes currently a safe or effective treatment for spinal cord injury based on reviews?

No, exosomes are not yet a safe or effective treatment for spinal cord injury in humans; evidence is limited to animal studies and early preclinical research.

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What did studies find about Danshen extract for spinal cord injury in animal models?

Studies in animal models found that Danshen extract significantly improves motor function, reduces inflammation, oxidative stress, apoptosis, and spinal cord edema after spinal cord injury.

Full answer →
Can repetitive transcranial magnetic stimulation reduce neuropathic pain for spinal cord injury patients?

Yes, repetitive transcranial magnetic stimulation (rTMS) can reduce neuropathic pain in spinal cord injury patients, based on multiple studies including meta-analyses and randomized trials.

Full answer →
See all 5 questions about Spinal Cord Injury →

All Spinal Cord Injury Articles