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Home › Conditions › Spinal Cord Injury

Spinal Cord Injury

21 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Spinal Cord Injury

99 trials tracked for Spinal Cord Injury: 18 in phase 3 or 4 and 3 with published results. The most-cited published study has 42 citations.

99Trials tracked
18Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 6 Phase 3 12 Phase 2 21 Phase 1 6 Other / NA 54
  1. Phase 3 Resistance Training and Testosterone After Spinal Cord Injury Completed · 42 cited
  2. Phase 3 Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury Completed · 18 cited
  3. Phase 3 Treatment of Post-SCI Hypotension Completed · 7 cited
  4. Phase 4 Bowel Care and Cardiovascular Function After Spinal Cord Injury Completed
  5. Phase 4 tSCI Contrast Enhanced Ultrasound Study Completed
  6. Phase 4 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed
Show 44 more trials
  1. Phase 4 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed
  2. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  3. Phase 4 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed
  4. Phase 3 Fenofibrate Treatment in SCI Completed
  5. Phase 3 Zoledronic Acid in Acute Spinal Cord Injury Completed
  6. Phase 3 Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury. Completed
  7. Phase 3 Testosterone Replacement Therapy in Chronic Spinal Cord Injury Completed
  8. Phase 3 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed
  9. Phase 3 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  10. Phase 3 Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury Completed
  11. Phase 3 Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI) Completed
  12. Phase 3 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  13. Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI) Completed
  14. Phase 2 Development of an Ergonomic Wheelchair Pushrim Completed
  15. Phase 2 Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury Completed
  16. Phase 2 Safety and Efficacy of L-NAME and Midodrine to Increase MAP Completed
  17. Phase 2 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI) Completed
  18. Phase 2 Effects of Vaporized Marijuana on Neuropathic Pain Completed
  19. Phase 2 Prevention of Bone Loss After Acute SCI by Zoledronic Acid Completed
  20. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial Completed
  21. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
  22. Phase 2 Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide Completed
  23. Phase 2 P300 Brain Computer Interface Keyboard to Operate Assistive Technology Completed
  24. Phase 2 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury Completed
  25. Phase 2 Testosterone and Long Pulse Stimulation After SCI Completed
  26. Phase 2 Neuromodulation Techniques After SCI Completed
  27. Phase 2 Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries Completed
  28. Phase 2 A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Completed
  29. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial Completed
  30. Phase 2 Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury Completed
  31. Phase 2 Multifaceted Treatment of Catheter-related Urinary Tract Infection Completed
  32. Phase 2 Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury Completed
  33. Phase 2 Enhancement of Pressure Healing With Pulsatile Lavage Completed
  34. Phase 1 Colonizing Neurogenic Bladders With Benign Flora Completed
  35. Phase 1 Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis Completed
  36. Phase 1 High Frequency SARS for Neurogenic Bladder and Bowel Emptying Completed
  37. Phase 1 Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia Completed
  38. Phase 1 Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI Completed
  39. Phase 1 Two Devices for Reflex Voiding Following Spinal Cord Injury Completed
  40. N/A Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Completed
  41. N/A Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury Completed
  42. N/A A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes Completed
  43. N/A The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury Completed
  44. N/A Powered Exoskeletons in Persons With SCI Completed

Showing the 50 most-cited and recently-updated of 99 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Integrated vocational rehabilitation models outperform traditional approaches for patients with spinal cord injury
Physical Medicine & Rehab Sys. Review
Integrated vocational rehabilitation models outperform traditional approaches for patients with spinal cord injury Federal policies and benefits traps hinder employment for spinal cord injuries
This scoping review analyzed 10 studies to map the evidence landscape regarding federal policies and vocational rehabilitation (VR) for indi…
Hidden financial barriers and outdated support models often prevent people with spinal cord injuries from returning to the workforce in the …
Frontiers Jun 8, 2026
Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
Neurology Meta-analysis
Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models Older rats recover less from spinal cord injury, but exercise helps them catch up
This systematic review of preclinical studies found that older animals demonstrate significantly lower locomotor scores after spinal cord in…
Aging makes spinal cord injury harder to recover from in rats. But exercise training can help older animals reach recovery levels similar to…
Frontiers Jun 2, 2026
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
Neurology Meta-analysis
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury Robot training improves walking after spinal cord injury
This systematic review and meta-analysis of 241 participants with spinal cord injury found that robot-assisted gait training led to signific…
Robot-assisted gait training helps people with spinal cord injury walk farther and more independently than standard rehab alone.
Frontiers May 30, 2026
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
Hematology Sys. Review
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps NINJ1 targeting shows promise for multiple sclerosis and other brain injuries
This narrative review examines NINJ1 targeting as a therapeutic strategy for multiple sclerosis, ischemic stroke, traumatic brain injury, sp…
A review suggests NINJ1 targeting could help treat multiple sclerosis, stroke, and other brain injuries, though more research is needed.
Frontiers May 30, 2026
Atractylenolide III shows neuroprotective effects in preclinical CNS disorder models
Drug Pipeline Sys. Review
Atractylenolide III shows neuroprotective effects in preclinical CNS disorder models Atractylenolide III shows promise for brain and nerve injuries in lab models
This narrative review summarizes preclinical evidence that Atractylenolide III exerts neuroprotective effects in models of cognitive impairm…
Atractylenolide III looks like a helpful option for brain and nerve damage in early lab tests, though human trials are needed.
Frontiers May 29, 2026
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Drug Pipeline Sys. Review
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Frontiers May 25, 2026
Systematic review of neural progenitor cell transplantation for spinal cord injury
Neurology Sys. Review
Systematic review of neural progenitor cell transplantation for spinal cord injury New review shows stem cell treatments for spinal cord injury are still in early testing stages
This systematic review synthesized evidence from 19 clinical trials on neural progenitor cell transplantation for spinal cord injury. The au…
A review of nineteen trials from ten countries found that stem cells might help spinal cord injury patients recover movement. However, no tr…
Frontiers May 25, 2026
Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models
Allergy & Immunology Meta-analysis
Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models Resveratrol shows promise for spinal cord injury in animal studies
This systematic review and meta-analysis of 38 preclinical animal studies found that resveratrol significantly improved locomotor recovery a…
A review of animal studies suggests resveratrol may improve movement and reduce damage after spinal cord injury, but human trials are needed…
Frontiers May 21, 2026
Systematic review and meta-analysis links injury severity and infection to hyponatremia in acute spinal cord injury patients
Rheumatology Meta-analysis
Systematic review and meta-analysis links injury severity and infection to hyponatremia in acute spinal cord injury patients Spinal injury patients face higher hyponatremia risk with certain factors
This systematic review and meta-analysis evaluated factors associated with hyponatremia in 2,355 patients with acute spinal cord injury. The…
A major review found that specific injury types and infections raise the chance of low sodium in spinal cord patients. Targeted monitoring i…
Frontiers May 5, 2026
Systematic review and meta-analysis links prior flap reconstruction and injury level to pressure injury recurrence in SCI patients
Physical Medicine & Rehab Meta-analysis
Systematic review and meta-analysis links prior flap reconstruction and injury level to pressure injury recurrence in SCI patients Prior flap surgery raises complication risk for spinal cord injury patients
This systematic review and meta-analysis evaluated risk factors for acute postoperative complications and pressure injury recurrence in 1976…
Past flap reconstruction surgery significantly increases the risk of complications and pressure injury recurrence for spinal cord injury pat…
May 1, 2026
Early transanal irrigation improves constipation and independence in spinal cord injury patients
Physical Medicine & Rehab RCT
Early transanal irrigation improves constipation and independence in spinal cord injury patients New Standard for Spinal Injury Bowel Care Emerges
This prospective, randomized, open-label, multicenter, parallel group study enrolled 22 SCI patients across four Italian spinal units.
Alex, 34, spent weeks in rehab after a spinal cord injury.
Apr 23, 2026
Meta-analysis finds rTMS improves neuropathic pain in spinal cord injury patients
Neurology Meta-analysis
Meta-analysis finds rTMS improves neuropathic pain in spinal cord injury patients rTMS may ease nerve pain after spinal cord injury, but not anxiety or depression
This meta-analysis of 7 RCTs with 159 patients found repetitive transcranial magnetic stimulation (rTMS) significantly improved neuropathic …
A review of seven trials found that repetitive magnetic stimulation reduced neuropathic pain in spinal cord injury patients, but did not sig…
Frontiers Apr 22, 2026

Questions about Spinal Cord Injury

Do Canadian policies for spinal cord injury supplies rely on means-testing rather than medical need?

Yes, Canadian policies for spinal cord injury supplies often use means-testing (income-based eligibility) rather than medical need, leading to wide inequities across provinces.

Full answer →
Are exosomes currently a safe or effective treatment for spinal cord injury based on reviews?

No, exosomes are not yet a safe or effective treatment for spinal cord injury in humans; evidence is limited to animal studies and early preclinical research.

Full answer →
What did studies find about Danshen extract for spinal cord injury in animal models?

Studies in animal models found that Danshen extract significantly improves motor function, reduces inflammation, oxidative stress, apoptosis, and spinal cord edema after spinal cord injury.

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Can repetitive transcranial magnetic stimulation reduce neuropathic pain for spinal cord injury patients?

Yes, repetitive transcranial magnetic stimulation (rTMS) can reduce neuropathic pain in spinal cord injury patients, based on multiple studies including meta-analyses and randomized trials.

Full answer →

All Spinal Cord Injury Articles