N/A
N=78
Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Bottom Line
View on ClinicalTrials.gov: NCT00880555 ↗Enrolled (actual)
78
Serious AEs
1.3%
Results posted
Mar 2016
Primary outcome: Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- May 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY FCI Score at Follow-up |
147.3; 164.0; 123.3; 150.8; 179.0; 0 | — |
Summary
Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.
Eligibility Criteria
Inclusion Criteria
- Veteran or non-veteran
- Age 50-89
- With normal cognition or memory impairment (MCI or mild AD)
- English speaking
- Right handed
- Adequate vision and hearing to take part in tests
- Able and willing to undergo MRI scan
- Medically and psychiatrically stable
- No other brain disease (such as tumor, Parkinson's disease, major stroke)
Exclusion Criteria
- Pregnancy
- Inability to tolerate MRI (due to metal in body or claustrophobia)
Data sourced from ClinicalTrials.gov (NCT00880555). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.