HIV and Kidney Function Study

Inclusion Criteria

• Male or female 18 years of age or older
• Confirmed HIV positive status
• Treatment with stable antiretroviral medications for a period of at least 3 months prior to the study

Exclusion Criteria

• Persons less than 18 years of age. Children are excluded due to the fact that they are still growing. Growth causes levels of creatinine to change differently than in adults, thus requiring the use of age-specific GFR estimating equations.
• Women who are either pregnant or who intend to become pregnant during the period of time in which the study visits will occur.
• Allergy to any of the contrast media used or a known allergy to iodine or shellfish. Subjects who are not sure if they have an iodine allergy because they have not eaten shellfish nor have never received contrast dye will be excluded from participation.
• Inability to cease taking medications that affect creatinine levels (e.g. trimethoprim containing medications, cimetidine) for one week prior to the study visit
• Inability to maintain stable regimen of non-steroidal anti-inflammatory agents, angiotension converting enzyme inhibitors and or angiotension receptor blockers for one week prior to study visit.
• Women who are breastfeeding
• Current treatment with amiodarone
• Current treatment with metformin
• Acute exacerbation of asthma or chronic obstructive lung disease in the past three months requiring hospitalization or oral steroid therapy
• Inadequate venous access
• People with kidney failure (currently undergoing or having received peritoneal dialysis or hemodialysis treatment within the past three months or estimated GFR (eGFR) < 15 ml/min per 1.73 m2)
• End stage conditions such as cirrhosis
• Active treatment for cancer
• Progressive neurological diseases
• Severe gastric immotility
• History of cognitive or physical impairments that will not allow completion of the study
• Inability to provide informed consent