N/A
Completed N=28
Effect of Oligofructose on Appetite in Overweight Subjects
Appetite Regulation · Obesity
Source: ClinicalTrials.gov NCT00912197 ↗
Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Dec 2020
Primary outcomePrimary: Subjective Appetite Ratings in Hunger Compared to Baseline — 4.8; 3.6; 3.6; 4.1 cm — p=0.135
Summary
This study seeks to look into the effects of oligofructose supplementation on appetite, energy intake, and body weight and body composition in overweight subjects. Compared to a placebo product (cellulose) oligofructose is hypothesised to suppress hunger and thereby reduce food intake moderately leading to a decrease in body weight.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subjective Appetite Ratings in Hunger Compared to Baseline |
4.8; 3.6; 3.6; 4.1 | 0.135 |
| PRIMARY Subjective Appetite Ratings in Fullness Compared to Baseline |
4.7; 4.2; 4.2; 4.1 | 0.688 |
| PRIMARY Body Weight |
83.7; 86; 84.1; 86.3 | 0.715 |
| PRIMARY Energy Intake |
873.16; 867.61; 760.19; 725.34 | 0.578 |
| PRIMARY Gut Hormone PYY |
— | — |
| SECONDARY Body Composition |
29.7; 31.1; 29.9; 31.2 | — |
| SECONDARY Imaging of Total Adipose Tissue |
36.3; 38.4; 37; 38.7 | — |
| SECONDARY Plasma Short-chain Fatty Acids Concentrations After Treatment |
81.3; 72.8; 5.4; 5.4; 0.9; 0.7 | 0.024 sig |
| SECONDARY Inflammatory Markers |
— | — |
| SECONDARY Glycemic Response |
4.8; 4.7 | — |
| SECONDARY Serum Insulin |
10.2; 9.6 | — |
| SECONDARY Breath Hydrogen Levels |
— | — |
Eligibility Criteria
Inclusion Criteria
- Healthy males and females aged 20-50
- BMI 25-35 kg/m2
- Weight stable for three months prior to enrollment in study (weight change < 3 kg over a period of three months)
- Habitual dietary fibre ≤ 25g/day (as assessed by 3-day dietary record)
- Non-smokers
- No current or history of endocrine disease, gastrointestinal disease, kidney or liver diseases, cardiovascular disease, pancreatitis, or cancer
- Hydrogen producers
Exclusion Criteria
- Use of antibiotic less than three months prior to participation in the study
- Participation in other research studies in the previous three months
- Blood donation less than three months before participation in study
- Anaemia
- Hypertension
- Pregnancy or breastfeeding
- Substance abuse
- Vegan diet
- Regular use of prebiotic, probiotic or symbiotic food items/ supplements
- Intense exercise undertaken for more than 5h per week
- Metallic or electronic implants e.g. pacemaker, cochlear ear implants, fixed dental braces
- Claustrophobia
- Depression
Data sourced from ClinicalTrials.gov (NCT00912197). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.