Phase 2
Completed N=70
Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection
Source: ClinicalTrials.gov NCT00918281 ↗Enrolled (actual)
70
Serious AEs
14.3%
Results posted
Jun 2014
Primary outcomePrimary: Test Image and Retest Image Reproducibility of Fluciclatide Injection ([18F]AH111585) Uptake by Solid Tumors Following Intravenous Administration of AH111585 (18F) Injection Via PET Imaging. — 4.536; 4.671; 0.0198; 4.584 Standardized Uptake Value
Summary
Study aimed to assess the reproducibility of PET imaging using AH111585 (18F) Injection. Subjects are evaluable if they undergo 2 administrations of AH111585 (18F) Injection (3 to 8 days apart) and the corresponding PET acquisitions, and tumors demonstrate detectable levels of 18F uptake on PET.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Test Image and Retest Image Reproducibility of Fluciclatide Injection ([18F]AH111585) Uptake by Solid Tumors Following Intravenous Administration of AH111585 (18F) Injection Via PET Imaging. |
4.536; 4.671; 0.0198; 4.584; 4.675; 0.0216 | — |
| SECONDARY The Safety of Greater Than or Equal to 2 Administrations, Each of a Maximum of 370MBq, Fluciclatide Injection (AH111585 (18F) Injection) in Subjects With Solid Primary or Metastatic Tumors. |
18; 47; 1; 3; 8; 7 | — |
Eligibility Criteria
Inclusion Criteria
- The subject has been diagnosed with at least one solid primary or metastatic tumor greater than 2.0 cm in diameter, including but not limited to NSCLC, RCC, GBM, melanoma, sarcoma, breast and H&N cancers.
- The subject has received clinical routine imaging diagnostic work-up within 8 weeks prior to the first [18F]AH111585 PET scan.
- The subject has a clinically acceptable (as judged by the investigator) physical examination at screening and is capable of self-care.
Exclusion Criteria
- The subject has known hyper- or hypo-coagulation syndromes.
- The subject has received chemotherapy within 3 weeks, or received radiotherapy, surgery or any other treatment against cancer within 4 weeks prior to the first [18F]AH111585 PET scan.
- The subject is scheduled to undergo chemotherapy, radiotherapy, surgery or any other treatment against cancer between the first and second [18F]AH111585 PET scans.
- The subject is scheduled to undergo biopsy for the target tumour between the first and second [18F]AH111585 PET scans.
- The subject has intra-hepatic tumour(s) only.
- For the immuno-histochemistry group, the subject's target tumour has been biopsied less than or equal to 1 week prior to the first [18F]AH111585 PET scan.
Data sourced from ClinicalTrials.gov (NCT00918281). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.