Phase 4 Completed N=100 Randomized Treatment

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Sedation

Source: ClinicalTrials.gov NCT00997321 ↗

Enrolled (actual)

100

Serious AEs

0.0%

Results posted

Mar 2012

Primary outcomePrimary: Respiratory Depression (Sub-clinical and Clinical Signs) — 0.4; 0.6 percentage of participants

Summary

This study is a clinical trial of moderate sedation with propofol versus moderate sedation with ketamine for procedural sedation in the Emergency Department.

Outcome Measures

Outcome	Result	p-value
PRIMARY Respiratory Depression (Sub-clinical and Clinical Signs)	0.4; 0.6	—
SECONDARY Time to Return of Baseline Mental Status	5; 14	—
SECONDARY Patient Reported Pain or Recall of the Procedure	0.06; 0.02	—
SECONDARY Depth of Sedation	2; 2	—

Eligibility Criteria

Inclusion Criteria

patients who require moderate procedural sedation with propofol in the ED

Exclusion Criteria

age > 17 years
pregnant
intoxicated
cannot give informed consent
allergy to ketamine or propofol
patient will require deep procedural sedation
ASA physical status score > 2

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00997321). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.