1 published article · Updated continuously
23 trials tracked for Sedation: 16 in phase 3 or 4 and 6 with published results. The most-cited published study has 115 citations.
Showing the 23 most-cited and recently-updated of 23 trials. Browse the full registry →
Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.
New clinical evidence indicates that Isoflurane is associated with a significantly higher percentage of time maintaining sedation depth within target ranges compared to Propofol [1, 2]. Furthermore, Isoflurane was associated with lower opioid usage during the study period compared to Propofol [1, 2], while no significant difference was found between the two regarding wake-up times [1, 2].
Dexmedetomidine is established as an effective sedative; studies show it can significantly reduce requirements for rescue medications like Propofol and Midazolam [15, 16] and is associated with a 100% physician-evaluated effectiveness rate in specific cohorts 22. Dexmedetomidine administration was also associated with significant decreases in minute ventilation and lower total doses of Fentanyl and Midazolam 4, as well as measurable changes in mean arterial pressure 19 and FLACC scores in pediatric populations 20.
Midazolam is utilized for sedation, though results regarding its specific efficacy in maintaining depth over 48 hours compared to other agents were not significantly different in terms of opioid use 14. Triazolam has been shown to achieve high levels of satisfaction among patients, surgeons, and anesthesia providers 5.
Other established findings include that Propofol did not result in significant changes in serum catecholamines 9 or intraocular pressure during Nitrous oxide sedation 10. Additionally, Propofol was associated with high patient satisfaction scores post-procedure 11.
AI synthesis of 9 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.
