1 published article · Updated continuously
23 trials tracked for Sedation: 16 in phase 3 or 4 and 6 with published results. The most-cited published study has 115 citations.
Showing the 23 most-cited and recently-updated of 23 trials. Browse the full registry →
Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.
Several trials evaluated various pharmacological agents for sedation. Isoflurane demonstrated a significantly higher percentage of time maintaining sedation depth within target ranges compared to propofol in two separate studies [1, 2]. In these same comparisons, isoflurane was associated with a lower use of opioids during the treatment period [1, 2], while no significant difference was found regarding wake-up times at the end of drug administration [1, 2].
Dexmedetomidine has been studied extensively for sedation. It was shown to significantly decrease minute ventilation and reduce the required amounts of fentanyl and midazolam 4. Clinical trials demonstrated that dexmedetomidine can achieve target sedation scores without requiring rescue propofol in a significant percentage of patients, with lower doses correlating to less rescue medication needed 15. Furthermore, dexmedetomidine was associated with stable oxygen saturation and no arrhythmias during administration 19, and it showed high physician-rated efficacy as a responder 22.
Other agents included midazolam, which was evaluated for maintaining sedation depth over 48 hours and in pediatric pre-induction settings [6, 14]. Propofol was utilized in various contexts, showing consistent results regarding respiratory depression and patient/provider satisfaction scores [9, 11, 13]. Triazolam was associated with high levels of patient, surgeon, and anesthesiologist satisfaction 5. Nitrous oxide showed no significant change in intraocular pressure during use 10, and chloral hydrate was used to complete study procedures 8.
AI synthesis of 8 cited trials, updated Jun 18, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.
