Phase 4
N=34
Effect of Vitamin D Supplementation on Muscle Mass and Function
Obesity · Insulin Resistance · Inflammation
Bottom Line
View on ClinicalTrials.gov: NCT01199926 ↗Enrolled (actual)
34
Serious AEs
—
Results posted
May 2015
Primary outcome: Primary: Muscle Function — 1.14; 1.50 kilograms
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Vitamin D (Dietary_supplement); Placebo (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Purdue University
- Primary completion
- Jul 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Muscle Function |
1.14; 1.50 | — |
| PRIMARY Glucose Tolerance |
-18.0; -25.7 | — |
| PRIMARY Inflammation |
0.64; -0.33 | — |
Summary
The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.
Eligibility Criteria
Inclusion Criteria
- Physical activity scores in the "low" to "very low" category
- Fitness estimations in the "below average" or lower categories
- body mass index scores >24.9 indicating overweight or obesity.
Exclusion Criteria
- Use of tanning booths or other artificial UV light exposure
- High baseline vitamin D and calcium intake
- Plans to visit sunny/warm destinations during the winter months/study period
- History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation
- Use of drugs to treat obesity (last 12 weeks)
- Use of over the counter anti-obesity agents (last 12 weeks)
- Recent initiation of an exercise program (last four weeks).
Data sourced from ClinicalTrials.gov (NCT01199926). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.