N/A
Completed N=213
Cognitive Training for Nicotine Dependence
Source: ClinicalTrials.gov NCT01252966 ↗Enrolled (actual)
213
Serious AEs
4.2%
Results posted
Jan 2017
Primary outcomePrimary: Point-prevalence Abstinence at End of Treatment — 38; 43 Percentage of participants — p=0.14
Summary
This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.
All participants received 8 weeks of standard nicotine patch therapy, smoking cessation counseling, and were randomized to 1 of 2 different training programs: cognitive training vs. control training.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Point-prevalence Abstinence at End of Treatment |
38; 43 | 0.14 |
| SECONDARY Point-prevalence Abstinence at 6-month Follow-up |
15; 25 | — |
| SECONDARY Cognitive Performance (Working Memory) |
0.22; 0.03 | 0.30 |
| SECONDARY Cognitive Performance (Response Inhibition) |
-0.84; -0.49 | 0.30 |
| SECONDARY Cognitive Performance (Attention) |
-0.27; 0.54 | 0.033 sig |
Eligibility Criteria
Inclusion:
- Healthy male and female treatment-seeking smokers who are between 18 and 65 years of age and self-report smoking at least 5 cigarettes (menthol and/or non-menthol) per day for at least the last 6 months
- Plan to live in the area for at least the next 8 months
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form
- Able to communicate fluently in English (speaking, writing, and reading)
- Have uninterrupted access to a home computer with sound capabilities, keyboard, mouse, and active Internet connection
- Provide a Carbon Monoxide (CO) breath test reading greater than or equal to 8 parts per million (ppm) at Intake Visit
Data sourced from ClinicalTrials.gov (NCT01252966). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.