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Home › Conditions › Nicotine Addiction

Nicotine Addiction

Part of Tobacco Dependence

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Nicotine Addiction

19 trials tracked for Nicotine Addiction: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 62 citations.

19Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3 Phase 1 3 Other / NA 10
  1. Phase 4 The END Perioperative Smoking Pilot Study Completed · 62 cited
  2. Phase 4 STOP Study: Effectiveness of Zyban in a Clinical Population Completed
  3. Phase 3 Pharmacogenetics of Nicotine Addiction Treatment Completed
  4. Phase 2 Quit Smoking Study for People Who Use E-Cigarettes Completed
  5. Phase 2 Effect of Galantamine on Smoking Abstinence Completed
  6. Phase 2 Effects of Semaglutide on Nicotine Intake Completed
Show 13 more trials
  1. Phase 1 Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine Completed
  2. Phase 1 Nicotine Reinforcement and Aversion in Young Adult Light Smokers Completed
  3. Phase 1 Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness Completed
  4. N/A Nicotine Receptor Levels and Smoking Cessation Completed
  5. N/A Acute and Chronic Nicotine Modulation of Reinforcement Learning Completed
  6. N/A Clinical Trial of Smoking Cessation Mobile Phone Program Completed
  7. N/A Neural Mechanisms Associated With Risk of Smoking Relapse Completed
  8. N/A A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults Completed
  9. N/A Cognitive Training for Nicotine Dependence Completed
  10. N/A Circuitry-Guided Smoking Cessation in Schizophrenia Completed
  11. N/A Innovative Digital Therapeutic for Smoking Cessation Completed
  12. N/A tDCS Effects on Resisting Smoking: Dose Ranging Study Completed
  13. N/A QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Nicotine Addiction: what the trials found

Pharmacological interventions have demonstrated varying levels of efficacy in treating nicotine addiction. Varenicline showed 7-day point prevalence quit rates at the end of treatment ranging from 17.2% to 38.5% 3, with follow-up quit rates at 6 months ranging from 12.9% to 22.0% 3.

Bupropion HCl was evaluated for smoking abstinence, showing a 7-day point prevalence of 128 to 320 2. Additionally, the use frequency of NicoDerm CQ (NRT) was recorded in clinical observations 1.

Recent results — preliminary, needs further review

  • Semaglutide is currently being investigated in Phase 2 trials for nicotine addiction 4.
  • Several non-pharmacological and experimental interventions are under investigation, including transcranial direct current stimulation (tDCS) 15, active TMS stimulation 13, and cognitive training 19.

For the clinician treating this condition

  • Varenicline is an established pharmacological option with documented quit rates at both end-of-treatment and 6-month follow-up 3.
  • Bupropion HCl is an established intervention for improving smoking abstinence 2.

AI synthesis of 7 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Report describes U.S. adults' intent and methods for smoking cessation
Infectious Disease
Report describes U.S. adults' intent and methods for smoking cessation Report examines how U.S. adults plan to quit smoking, but findings are not yet available
An observational report describes smoking cessation intentions and methods among U.S.
A new report looks at how U.S. adults plan to quit smoking, but the specific findings have not been released yet.
CDC Apr 4, 2026

Research across Tobacco Dependence

Related studies from across the Tobacco Dependence family.

Observational study examines smoking cessation advice from health professionals to US adults
Infectious Disease
Observational study examines smoking cessation advice from health professionals to US adults How many smokers get told to quit by their doctor?
An observational study assessed the percentage of current cigarette smokers aged ≥18 years in the United States who received advice from a h…
A new study looked at how often doctors and nurses tell their patients who smoke that they should quit.
CDC Apr 4, 2026