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Home › Conditions › Nicotine Addiction

Nicotine Addiction

Part of Tobacco Dependence

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Nicotine Addiction

19 trials tracked for Nicotine Addiction: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 62 citations.

19Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3 Phase 1 3 Other / NA 10
  1. Phase 4 The END Perioperative Smoking Pilot Study Completed · 62 cited
  2. Phase 4 STOP Study: Effectiveness of Zyban in a Clinical Population Completed
  3. Phase 3 Pharmacogenetics of Nicotine Addiction Treatment Completed
  4. Phase 2 Quit Smoking Study for People Who Use E-Cigarettes Completed
  5. Phase 2 Effect of Galantamine on Smoking Abstinence Completed
  6. Phase 2 Effects of Semaglutide on Nicotine Intake Completed
Show 13 more trials
  1. Phase 1 Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine Completed
  2. Phase 1 Nicotine Reinforcement and Aversion in Young Adult Light Smokers Completed
  3. Phase 1 Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness Completed
  4. N/A Nicotine Receptor Levels and Smoking Cessation Completed
  5. N/A Acute and Chronic Nicotine Modulation of Reinforcement Learning Completed
  6. N/A Clinical Trial of Smoking Cessation Mobile Phone Program Completed
  7. N/A Neural Mechanisms Associated With Risk of Smoking Relapse Completed
  8. N/A A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults Completed
  9. N/A Cognitive Training for Nicotine Dependence Completed
  10. N/A Circuitry-Guided Smoking Cessation in Schizophrenia Completed
  11. N/A Innovative Digital Therapeutic for Smoking Cessation Completed
  12. N/A tDCS Effects on Resisting Smoking: Dose Ranging Study Completed
  13. N/A QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Report describes U.S. adults' intent and methods for smoking cessation
Infectious Disease
Report describes U.S. adults' intent and methods for smoking cessation Report examines how U.S. adults plan to quit smoking, but findings are not yet available
An observational report describes smoking cessation intentions and methods among U.S.
A new report looks at how U.S. adults plan to quit smoking, but the specific findings have not been released yet.
CDC Apr 4, 2026

Research across Tobacco Dependence

Related studies from across the Tobacco Dependence family.

Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Observational study examines smoking cessation advice from health professionals to US adults
Infectious Disease
Observational study examines smoking cessation advice from health professionals to US adults How many smokers get told to quit by their doctor?
An observational study assessed the percentage of current cigarette smokers aged ≥18 years in the United States who received advice from a h…
A new study looked at how often doctors and nurses tell their patients who smoke that they should quit.
CDC Apr 4, 2026