N/A
N=120
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
Kidney Diseases · Kidney Failure, Chronic · Kidney Failure · Renal Insufficiency · Renal Insufficiency, Chronic
Bottom Line
View on ClinicalTrials.gov: NCT01289548 ↗Enrolled (actual)
120
Serious AEs
0.0%
Results posted
Sep 2013
Primary outcome: Primary: Plasma Creatine Concentration of the Recipients — 849.5; 878.5; 771.0; 776.5 μmol/l
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- remote ischaemic preconditioning (Device)
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- Huazhong University of Science and Technology
- Primary completion
- Nov 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plasma Creatine Concentration of the Recipients |
849.5; 878.5; 771.0; 776.5; 797.5; 725.5 | — |
| PRIMARY Urinary Output of the Recipients Postoperatively |
175; 300; 100; 1875; 2650; 1850 | — |
| PRIMARY Plasma Concentration of NGAL in the Recipients |
1478.7; 1269.1; 1377.9; 317.8; 370.1; 256.2 | — |
| SECONDARY Acute Rejection of Transplanted Kidney |
0; 0; 0 | — |
| SECONDARY Delayed Graft Function |
1; 2; 2 | — |
| SECONDARY Length of Postoperative Hospital Stay |
17; 15; 14.5 | — |
| SECONDARY Total Costs During the Hospitalization |
82499; 83574; 82298 | — |
| SECONDARY Urine Concentration of NAG Preoperatively in Recipients |
20.79; 15.25; 16.09 | — |
| SECONDARY Urine Concentration of NAG Postoperatively in Recipients |
16.58; 18.54; 17.06; 3.74; 4.45; 6.46 | — |
| SECONDARY Urine Concentration of RBP Preoperatively in the Recipients |
2.222; 2.168; 1.964 | — |
| SECONDARY Urine Concentration of RBP Postoperatively in the Recipients |
2.18; 1.93; 2.05; 2.23; 1.94; 2.27 | — |
| SECONDARY Plasma Concentration of SOD in the Recipients |
105.04; 96.77; 113.51; 88.86; 94.90; 112.25 | — |
| SECONDARY Plasma Concentration of MDA in the Recipients |
2.96; 3.34; 3.14; 3.58; 4.15; 3.91 | — |
Summary
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
Eligibility Criteria
Inclusion Criteria
- Subject capable of giving written informed consent, with end-stage kidney disease, who is a suitable candidate for primary kidney transplantation
- Living donors
- Compatible ABO blood type
- PRA < 20%
Exclusion Criteria
- Re-transplant patients
- Those with peripheral vascular disease affecting the lower limbs
Data sourced from ClinicalTrials.gov (NCT01289548). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.