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Home › Conditions › Renal insufficiency

Renal insufficiency

Part of Kidney Diseases

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Renal insufficiency

32 trials tracked for Renal insufficiency: 5 in phase 3 or 4 and 1 with published results. The most-cited published study has 101 citations.

32Trials tracked
5Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 3 Phase 1 18 Other / NA 6
  1. Phase 4 Glargine Dosing in Hospitalized Patients With Type 2 Diabetes and Renal Insufficiency Completed · 101 cited
  2. Phase 4 Renal Safety Evaluation After Dotarem®-Enhanced MRI Completed
  3. Phase 4 Post-marketing Safety Study in Patients With Moderate Renal Insufficiency Who Receive Omniscan for Contrast-enhanced Magnetic Resonance Imaging (MRI) Completed
  4. Phase 3 An Efficacy, Safety, and Tolerability Study of Canagliflozin in Patients With Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment Completed
  5. Phase 3 Efficacy and Safety of Empagliflozin (BI 10773) in Patients With Type 2 Diabetes and Renal Impairment Completed
  6. Phase 2 Assessing the Behavior of Met DR in Subjects With Kidney Dysfunction Completed
Show 26 more trials
  1. Phase 2 A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated Completed
  2. Phase 2 Study of the Safety and Pharmacokinetics of Carfilzomib in Patients With Relapsed and Refractory Multiple Myeloma and Varying Degrees of Renal Function Completed
  3. Phase 1 A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems Completed
  4. Phase 1 Pharmacokinetics of Midazolam, Dabigatran, Pitavastatin, Atorvastatin, and Rosuvastatin in Participants With Renal Insufficiency in the Presence and Absence of Rifampin (MK-0000-386) Completed
  5. Phase 1 Pharmacokinetic Assessment of Single-Dose Odanacatib (MK-0822) in Subjects With Severe Renal Insufficiency (MK-0822-067) Completed
  6. Phase 1 A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Kidney Problems Completed
  7. Phase 1 The Pharmacokinetics of Gefapixant (MK-7264) in Participants With Renal Insufficiency (MK-7264-026) Completed
  8. Phase 1 Afatinib in Subjects With Kidney Dysfunction Completed
  9. Phase 1 Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy Participants Completed
  10. Phase 1 Pharmacokinetic Study of Aztreonam-Avibactam in Severe Renal Impairment Completed
  11. Phase 1 Renal Allograft Tolerance Through Mixed Chimerism (Belatacept) Completed
  12. Phase 1 A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems Completed
  13. Phase 1 A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 1467335 is Processed in the Body Completed
  14. Phase 1 PF-04634817 Renal Impairment Study Completed
  15. Phase 1 Pharmacokinetics of Sugammadex (MK-8616) in Participants With Moderate and Severe Renal Insufficiency (MK-8616-105) Completed
  16. Phase 1 A Study of Effect of Selpercatinib (LY3527723) in Participants With Normal and Impaired Renal Function Completed
  17. Phase 1 PK and PD Study of IDN-6556 in Subjects With Severe Renal Impairment and Matched Healthy Volunteers Completed
  18. Phase 1 Pharmacokinetics (PK) of Dalfampridine-ER 7.5 mg BID in Healthy Volunteers and Subjects With Mild or Moderate Renal Impairment Completed
  19. Phase 1 Pharmacokinetics of Peginterferon Alfa-2b in Participants With Moderate and Severe Renal Impairment (P05655) Completed
  20. Phase 1 A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function Completed
  21. N/A Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Moderate Renal Insufficiency After the Administration of Magnevist Completed
  22. N/A Effects of Zoledronic Acid Versus Alendronate on Bone Loss After Kidney and Kidney/Pancreas Transplants Completed
  23. N/A XIENCE 28 USA Study Completed
  24. N/A Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation Completed
  25. N/A XIENCE 28 Global Study Completed
  26. N/A Observational Study on the Incidence of NSF in Renal Impaired Patients Following Dotarem Administration Completed

Showing the 32 most-cited and recently-updated of 32 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Renal insufficiency: what the trials found

Newer clinical evidence demonstrates that BI 10773 significantly reduces HbA1c levels in patients with mild or moderate renal impairment compared to placebo (p<0.0001) 5. Specifically, significant reductions were observed in both the mild renal impairment subgroup (p<0.0001) and the moderate renal impairment subgroup (p<0.0001) 5.

Canagliflozin has been shown to significantly reduce Fasting Plasma Glucose (FPG) from baseline at week 26 (p=0.021) 6. While Canagliflozin also resulted in a statistically significant reduction in HbA1c at week 26 compared to placebo (p=0.012), the difference in the percentage of patients achieving an HbA1c <7% at week 26 did not reach statistical significance (p=0.227) 6.

Recent results — preliminary, needs further review

  • * BI 1015550 was evaluated in a Phase 1 trial 10. * Selpercatinib showed that approximately 4.8% to 10.1% of the administered dose was excreted in urine during a Phase 1 study 11.

For the clinician treating this condition

  • BI 10773 is effective for HbA1c reduction in patients with mild to moderate renal impairment 5.
  • Canagliflozin significantly reduces Fasting Plasma Glucose at week 26, though it did not show a statistically significant difference in the proportion of patients reaching an HbA1c <7% compared to placebo 6.

AI synthesis of 4 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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