N/A N=282,368

Kaiser Permanente HIV Cohort Study

HIV · AIDS

Bottom Line

View on ClinicalTrials.gov: NCT01339403 ↗

Enrolled (actual)

282,368

Serious AEs

—

Results posted

Apr 2015

Primary outcome: Primary: Incidence Rate of Malignancies — 513; 3; 238; 20 malignancies per 100,000 person-years — p=<0.001

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: non-interventional trial (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: ViiV Healthcare
Primary completion: Oct 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Incidence Rate of Malignancies	513; 3; 238; 20; 25; 7	<0.001 sig
PRIMARY Incidence Rate of Myocardial Infarction and Ischemia	435; 313	<0.001 sig
PRIMARY Incidence Rate of Acquired Immunodeficiency Syndrome (AIDS)-Defining Opportunistic Infections	1002; 15; 760; 2; 640; 74	<0.001 sig
PRIMARY Incidence Rate of Liver Failure	492; 105	<0.001 sig
PRIMARY Incidence Rate of Liver Related Death	202; 29	<0.001 sig
PRIMARY Incidence Rate of Rhabdomyolysis	235; 28	<0.001 sig
PRIMARY Incidence Rate of All-Cause Mortality	1827; 326	<0.001 sig
PRIMARY Incidence Rate of Viral Encephalitis	30; 2	<0.001 sig

Summary

Human Immunodeficiency Virus (HIV) infected patients in the Kaiser Permanente HIV registry wil be followed in the usual clinical care to estimate the rates of specified clinical events. The rates will be stratified by relevant characteristics like age, CD4 counts, HIV Viral Load (VL), HIV medication history. The rates in the HIV infected cohort wil be compared with the rates of these events in patients in the Kaiser Permanente database who are not infected with HIV.

Eligibility Criteria

Inclusion Criteria

HIV infection.

Exclusion Criteria

None

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01339403). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.