Phase 4
Completed N=22
An Allergen BioCube (ABC) Study Evaluating the Efficacy of Fluticasone Propionate Nasal Spray Compared to Placebo
Source: ClinicalTrials.gov NCT01439815 ↗Enrolled (actual)
22
Serious AEs
0.0%
Results posted
Mar 2021
Primary outcomePrimary: Change in Total Nasal Signs and Symptoms Score From Baseline (Day 0) to Visit 5 (Day 16) — -0.7; 0.3; -2.8; 0.9 units on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of this study is to evaluate the onset of action of fluticasone propionate nasal spray compared to placebo nasal spray in reducing nasal allergic signs and symptoms following ragweed exposure in the Allergen BioCube (ABC) after up to 14 days of at home dosing.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Total Nasal Signs and Symptoms Score From Baseline (Day 0) to Visit 5 (Day 16) |
-0.7; 0.3; -2.8; 0.9; -4.1; -0.6 | — |
| SECONDARY Change in Baseline Nasal Itching Score on Day 0 to Average Nasal Itching Score on Day 16 |
-0.2; 0.1; -1; 0.3; -1; -0.1 | — |
| SECONDARY Change in Baseline Sneezing Score on Day 0 to Average Sneezing Score on Day 16 |
-0.1; 0.2; -0.5; 0.1; -0.9; -0.4 | — |
| SECONDARY Change in Baseline Rhinorrhea Score on Day 0 to Average Rhinorrhea Score on Day 16 |
-0.4; 0; -0.9; 0.4; -1.5; 0 | — |
| SECONDARY Change in Baseline Nasal Congestion Score on Day 0 to Average Nasal Congestion Score on Day 16 |
-0.1; 0; -0.4; 0.1; -0.7; -0.1 | — |
Eligibility Criteria
Inclusion Criteria
- provide written informed consent and signed HIPAA form;
- be able and willing to follow all instructions and attend the study visits;
- if female and of childbearing potential, be not pregnant, nursing or planning a pregnancy, be willing to submit a pregnancy test at Visit 1 and at exit visit, and to use adequate method of birth control
- have a positive history of seasonal allergic rhinitis to ragweed;
- have a positive skin test reaction to ragweed of within the past 24 months;
- manifest sufficient allergic rhinitis symptoms during ragweed exposure in the ABC
Exclusion Criteria
- known intolerance or allergy to antihistamines or corticosteroids;
- have a compromised lung function at Visit 1;
- develop a compromised lung function at Visits 2-6
- have any presence of active sinus or nasal infection at any visit;
- have experienced an acute upper or lower respiratory tract infection or acute sinusitis within 30 days of visit 1;
- have significant nasal anatomical deformities or any condition that does not allow subject to breathe through the nose (includes, but is not limited to: septal deviation, septal perforations, nasal polyps, rhinitis medicamentosa)
- have had any nasal surgical intervention in the past;
- have a known history of glaucoma
- have planned surgery (nasal, ocular or systemic) during the trial period or within 30 days thereafter;
- inability or refusal to discontinue contact lens wear during all visits;
- use disallowed medications during the study or appropriate pre-study washout period
Data sourced from ClinicalTrials.gov (NCT01439815). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.